Lipid Peroxidation in the Pathology of the Retina

Doly, M.; Droy-Lefaix, Marie-Thérèse

doi:10.1007/978-3-642-77609-0_10

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Biochemical Analysis1

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2008

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“…Eyes were homogenized in 0.2 M potassium phosphate buffer, pH 7.0, and frozen at -20 ° C until used. It has been demonstrated that 97% of the antioxidant content in these samples corresponded to the retina [24,25] .…”

Section: Biochemical Analysismentioning

confidence: 99%

Transient Bevacizumab (Avastin)-Induced Alterations in Rat Eyes

Sancho‐Tello¹,

Johnsen-Soriano²,

Muriach

et al. 2008

Ophthalmic Res

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Aims: To study the histopathological, biochemical and functional effects of intravitreal bevacizumab on the rat eye, with special emphasis on its immediate pro-inflammatory features eventually associated with cellular oxidative burden. Methods: Histopathological evaluation was performed 24 h, 1 and 4 weeks after bevacizumab (75 μg/rat eye) or saline intravitreal injection, as well as biochemical analysis of oxidative stress-related markers and electroretinograms. Results: Bevacizumab induces a transient inflammatory reaction together with a modification of the b-wave amplitude and latency of the electroretinogram. No changes were observed in any of the oxidative stress markers studied at any time after injection. Conclusion: Intravitreal bevacizumab injection per se generates an immediate, transient and mild inflammation of the rat eye, which is not associated with oxidative stress in ocular tissues.

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Section: Biochemical Analysismentioning

confidence: 99%