1983
DOI: 10.1016/0005-2760(83)90117-0
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Lipid peroxidation of human erythrocyte ghosts induced by organic hydroperoxides

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Cited by 100 publications
(17 citation statements)
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“…24 Renal dysfunction in rats in septic shock has been reported to improve in the presence of free radical scavengers. 6,7 ROS show their pathophysiological effects by directly attacking lipids 25 and proteins 26 in biological membranes, causing their dysfunction in cases of ROS overproduction or ineffective ROS scavenging. MDA is produced by lipid peroxidation caused by ROS in biological membranes, and it is a reliable indicator of oxidative damage.…”
Section: Discussionmentioning
confidence: 99%
“…24 Renal dysfunction in rats in septic shock has been reported to improve in the presence of free radical scavengers. 6,7 ROS show their pathophysiological effects by directly attacking lipids 25 and proteins 26 in biological membranes, causing their dysfunction in cases of ROS overproduction or ineffective ROS scavenging. MDA is produced by lipid peroxidation caused by ROS in biological membranes, and it is a reliable indicator of oxidative damage.…”
Section: Discussionmentioning
confidence: 99%
“…The resulting changes in membrane phospholipids may lead to increase calcium permeability, integral protein failure and cell death. Free radicals are very reactive and directly attack lipids [42] and proteins [43] in biological membranes at local sites of generation, causing their dysfunction [44,45]. Malondialdehyde produced by lipid peroxidation causes cross-linking and polymerization of membrane components.…”
Section: Research Articlesmentioning
confidence: 99%
“…Hemoglobin may be oxidized to methemoglobin (metHB) by tBHP (16), and metHB itself may lead to peroxidative changes of the cell membranes (21)(22)(23). On the other hand, tBHP can cause peroxidative changes in the purified erythrocyte membranes (ghosts) without metHB (24,25). Therefore, molecular mechanisms of the peroxidation of erythrocyte membranes by tBHP may be complicated.…”
mentioning
confidence: 99%