Lipid-peroxidation products and antioxidants in plasma of cigarette smokers

Pré, J.; Floch, A Le

doi:10.1093/clinchem/36.10.1849

Cited by 16 publications

(4 citation statements)

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“…Analytical methods for measurement of MDA in biological samples have been thoroughly reviewed and discussed in recent reviews [88,92]. Whilst TBAbased measurements of MDA have largely shown increased levels of this prototype lipid peroxidation product in blood plasma of smokers as compared to nonsmokers [93][94][95][96][97][98][99][100], divergent results have also been reported [101,102]. For the most part, the discrepancies in results have been ascribed to the methodological differences (pre-analytical and analytical issues), and/or biological variables (e.g., characteristics of the study population), as described above.…”

Section: Oxidative Damage To Lipids: Connection With Smoking and Cancermentioning

confidence: 99%

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer

Caliri

Tommasi

Besaratinia

2021

Mutation Research/Reviews in Mutation Research

315

139

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Smoking is a major risk factor for a variety of diseases, including cancer and immune-mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including a host of reactive oxygen-and nitrogen species (ROS and RNS), among others, that can damage cellular and sub-cellular targets, such as lipids, proteins, and nucleic acids. A growing body of evidence supports a key role for smoking-induced ROS and the resulting oxidative stress in inflammation and carcinogenesis. This comprehensive and up-to-date review covers four interrelated topics, including 'smoking', 'oxidative stress', 'inflammation', and 'cancer'. The review discusses each of the four topics, while exploring the intersections among the topics by highlighting the macromolecular damage attributable to ROS. Specifically, oxidative damage to macromolecular targets, such as lipid peroxidation, post-translational modification of proteins, and DNA adduction, as well as enzymatic and non-enzymatic antioxidant defense mechanisms, and the multi-faceted repair pathways of oxidized lesions are described. Also discussed are the biological consequences of oxidative damage to macromolecules if they evade the defense mechanisms and/or are not repaired properly or in time. Emphasis is placed on the genetic-and epigenetic alterations that may lead to transcriptional deregulation of functionally-important genes and disruption of regulatory elements. Smoking-associated oxidative stress also activates the inflammatory response pathway, which triggers a cascade of events of which ROS production is an initial yet indispensable step. The release of ROS at the site of damage and inflammation helps combat foreign pathogens and restores the injured tissue, while simultaneously increasing the burden of oxidative stress. This creates a vicious cycle in which smoking-related oxidative stress causes inflammation, which in turn, results in further generation of ROS, and potentially increased oxidative damage to macromolecular targets that may lead to cancer initiation and/or progression.

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Section: Oxidative Damage To Lipids: Connection With Smoking and Cancermentioning

confidence: 99%

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer

Caliri

Tommasi

Besaratinia

2021

Mutation Research/Reviews in Mutation Research

315

139

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“…In freshly collected EBC and bronchoalveolar liquid (BAL) samples of healthy young humans, we have measured MDA concentrations of the order of 50 nM by GC–MS/MS (unpublished data). Discrepant data were reported with respect to the subjects age, gender, smoking and alcohol consumption ( Table 1 ) [69] , [76] , [77] , [78] , [79] , [80] , [81] , [82] .…”

Section: Reference Values and Intervalsmentioning

confidence: 99%

GC–MS and GC–MS/MS measurement of malondialdehyde (MDA) in clinical studies: Pre-analytical and clinical considerations

Tsikas

2023

Journal of Mass Spectrometry and Advances in the Clinical Lab

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“…Cigarette smoke is well known to contain many oxidant molecules capable of causing various forms of oxidative damage [54]. Further, it has been demonstrated that cigarette smoking increases peroxidation products in plasma [55] [56]. Therefore, current heavy smokers, those who smoked more than 20 cigarettes per day for at least one year, were chosen for this double-blinded, placebo-controlled clinical trial [57].…”

Section: Human Antioxidant Studiesmentioning

confidence: 99%

The Influence of Noni Fruit Juice on Immune System Function

West,

Uwaya,

Isami

et al. 2023

JBM

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Morinda citrifolia (noni) fruit juice has the potential to influence immune system function. This review discusses results from several human and animal studies that provide insight into the potential mechanisms of action by which noni juice exerts its immunomodulatory effects. Increased natural killer cell activity is a likely a major contributor to the improved health outcomes and increased survival times described in case reports and as observed in LLC and S180 tumor bearing mice. Increased interferon-gamma (IFN-γ) production is also an important mechanism of action through which noni improves immune function. IFN-γ promotes natural killer cell activity and phagocytosis, activities both seen in human and bovine studies as well as in rodents. Noni promotes regulatory cytokine expression, such as IL-2 which stimulates CD4+ T cell differentiation. Noni juice appears to influence this process via kinase 1/2 (ERK1/2), protein kinase B (Akt) and nuclear factor-kappa-beta signaling. As oxidative status is known to influence immune function, this review also discusses the notable antioxidant properties of noni juice that have been demonstrated in human trials.

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Lipid-peroxidation products and antioxidants in plasma of cigarette smokers

Cited by 16 publications

References 0 publications

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer

GC–MS and GC–MS/MS measurement of malondialdehyde (MDA) in clinical studies: Pre-analytical and clinical considerations

The Influence of Noni Fruit Juice on Immune System Function

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