Lipid peroxidation products, selenium-dependent glutathione peroxidase and vitamin E in normal pregnancy

Uotila, Jukka; Tuimala, Risto; Aarnio, Teija; Pyykkö, Kaija; Ahotupa, Markku

doi:10.1016/0028-2243(91)90168-k

Cited by 96 publications

(58 citation statements)

References 17 publications

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“…Only two investigations reported decreasing lipid peroxides during pregnancy (Uotila et al 1991;Naziroglu et al 2004). Uotila et al (1991) reported that lipid peroxide concentrations tended to decrease in the progression of pregnancy in women.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Rate of Lipid Peroxidation in Plasma and Selected Blood Antioxidants before and during Pregnancy in Ewes

2009

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Pregnancy is a condition that favours oxidative stress. The aim of this study was to evaluate the oxidant and antioxidant status by measuring glutathione peroxidase (GSH-Px), catalase (CAT) activities and malondialdehyde (MDA) and glutathione (GSH) concentrations before and during pregnancy in ewes. Twelve healthy female and two healthy male Awassi sheep, aged 4-5 years, weighing approximately 50 -55 kg each, were used in the study. The ewes' blood samples were taken before synchronization and during pregnancy (on 25 th days of each month of pregnancy). Plasma MDA concentrations in the 2 nd and 3 rd months of pregnancy in ewes were lower than in the 1 st , 4 th , 5 th months of pregnancy and in the non-pregnant ewes. GSH concentrations and GSH-Px activities during pregnancy were increased (P < 0.01). GSH concentrations and GSH-Px activities were the highest in the 2 nd and 3 rd months of pregnancy. CAT activities were decreased after the 1 st month of pregnancy in ewes (P < 0.001). They were the lowest in the 2 nd and 3 rd months of pregnancy. The findings of our study show decreased CAT activities and elevated GSH concentrations and GSH-Px activities after the 1 st month of pregnancy in ewes. These changes in the indicators under study may indicate a predisposition to oxidative stress in the 2 nd and 3 rd month of pregnancy in ewes. Awassi sheep, pregnancy, oxidant and antioxidant status

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Section: Discussionmentioning

confidence: 99%

Changes in the Rate of Lipid Peroxidation in Plasma and Selected Blood Antioxidants before and during Pregnancy in Ewes

2009

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“…Chappell et al (2002) also reported that plasma levels of ascorbic acid in healthy pregnant women were stable over the gestation. We performed measurements for the serum vitamins during the second trimester (24-28 gestational weeks), because it was suggested that the evaluation for the antioxidant vitamin concentrations in mid-term pregnancy is important as the lipid peroxidation products are known to attain the highest level in the second trimester (Uotila et al, 1991). In addition, plasma vitamin E concentrations have been reported to increase throughout normal pregnancy, and the progressive increase was most noticeable between 24 and 32 weeks (Wang et al, 1991;Tamura et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Influence of maternal serum levels of vitamins C and E during the second trimester on birth weight and length

et al. 2004

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Objective: It has been known that maternal oxidative stress during pregnancy plays an important role in fetal growth. However, the association between antioxidant vitamin levels and birth outcomes is not conclusive. We investigated the relationship between maternal serum levels of vitamins C and E during the second trimester and birth weight and length. Design: Prospective cohort study. Setting: Outpatient-clinic of obstetrics, Ewha Womans University Hospital, South Korea. Subjects and methods: The study subjects were 239 healthy, pregnant women who visited an obstetric clinic for antenatal care, and their singleton live births, in Seoul, Korea, between August 2001 and March 2003. We measured the levels of vitamins C and E in maternal serum during the period 24-28 gestational weeks. Each woman was interviewed for dietary intake by trained interviewers during the second trimester. Results: The serum concentration of maternal vitamin C during the second trimester was significantly associated with birth weight and length in the group of full-term deliveries. An increase of 1 mg/ml in the serum vitamin C level increased the birth weight by 27.2 g and the birth length by 0.17 cm. When we considered the levels of vitamins C and E together in the relationship with birth weight and length, we found that the heaviest birth weight and the longest birth length belonged to the group of upper vitamin C/ upper vitamin E. However, dietary intake estimated by 24-h recall method was not a predictor of the levels of serum vitamins C and E. Conclusion: We found that maternal serum vitamin C levels during the second trimester were positively correlated with birth weight and length in full-term babies. We also found that birth weight and length were highest when the levels of both vitamins C and E were high. Our results indicate the importance of antioxidant nutrient balance for pregnant women who are exposed to various oxidants through food, drinking water, or inhaled air.

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“…Iron overload can promote the generation of free radicals and result in deleterious cellular damages. Free radical-mediated tissue damage is generally accepted as a major mechanism underlying the occurrence of GDM [7,8,9] .…”

Section: Serum Ferritin Levels In Pregnancymentioning

confidence: 99%

Serum Ferritin in Gestational Diabetes

Das¹

2017

JMSCR

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Lipid peroxidation products, selenium-dependent glutathione peroxidase and vitamin E in normal pregnancy

Cited by 96 publications

References 17 publications

Changes in the Rate of Lipid Peroxidation in Plasma and Selected Blood Antioxidants before and during Pregnancy in Ewes

Changes in the Rate of Lipid Peroxidation in Plasma and Selected Blood Antioxidants before and during Pregnancy in Ewes

Influence of maternal serum levels of vitamins C and E during the second trimester on birth weight and length

Serum Ferritin in Gestational Diabetes

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