Lipid Peroxides and the Induction of Hepatic Microsomal Cytochrome <i>P</i>-450 in the Rat

Marshall, William; Naughton, Carol

doi:10.1042/bst0020992

Biochemical Society Transactions

1974

DOI: 10.1042/bst0020992

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Lipid Peroxides and the Induction of Hepatic Microsomal Cytochrome P-450 in the Rat

William Marshall

Carol Naughton

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1978

1981

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Cited by 5 publications

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Subcellular distribution of the cytochrome P‐450 complex and glutathione peroxidase activity in vitamin E and essential fatty acid deficiency

Jensen

Clausen

1981

Lipids

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Glutathione peroxidase (EC 1.11.1.9.) (GSHPx) and P-450 activity were measured in hepatic mitochondrial and microsomal fractions from rats deficient in vitamin E and/or essential fatty acids (EFA). The data were compared to corresponding normal values. GSHPx was significantly decreased in the mitochondrial matrix from animals in all 3 deficiency states. In vitamin E deficiency, a non-significant decreased GSHPx activity was found in mitochondrial membranes. Opposite to these findings, GSHPx was significantly increased in mitochondrial membranes of EFA-deficient animals. In combined EFA and vitamin E deficiency, the mitochondrial membrane GSHPx activity was only insignificantly increased. The P-450 complex activity was not detectable in the mitochondrial matrix. In mitochondrial membranes and microsomes, the P-450 complex activity changed parallel to the GSHPx activity.

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Subcellular distribution of the cytochrome P‐450 complex and glutathione peroxidase activity in vitamin E and essential fatty acid deficiency

Jensen

Clausen

1981

Lipids

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Excited states of oxygen in biology: Their possible involvement in cytochrome P450 linked oxidations as well as in the induction of the P450 system by many diverse compounds

Paine

1978

Biochemical Pharmacology

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Loss of microsomal components in drug-induced liver damage, in cholestasis and after administration of chemicals which stimulate heme catabolism

Matteis

1978

Pharmacology & Therapeutics. Part A: Chemotherapy, Toxicolo

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Lipid Peroxides and the Induction of Hepatic Microsomal Cytochrome P-450 in the Rat

Cited by 5 publications

References 0 publications

Subcellular distribution of the cytochrome P‐450 complex and glutathione peroxidase activity in vitamin E and essential fatty acid deficiency

Subcellular distribution of the cytochrome P‐450 complex and glutathione peroxidase activity in vitamin E and essential fatty acid deficiency

Excited states of oxygen in biology: Their possible involvement in cytochrome P450 linked oxidations as well as in the induction of the P450 system by many diverse compounds

Loss of microsomal components in drug-induced liver damage, in cholestasis and after administration of chemicals which stimulate heme catabolism

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