Lipid Polymer Hybrid Nanoparticles: A Novel Approach for Drug Delivery

Abstract

Applications of nanotechnology and material sciences emerge in the development of various novel drug delivery systems that have been proven as promising clinically. Among these, liposomes, noisome, polymeric carriers and lipid-based delivery system were extensively explored and enter into clinical trials and clinical applications. However, each system has its own pros and cons in term of different physicochemical, pharmacokinetics and therapeutics aspects. Lipid-polymer hybrid carriers merge the potential benefit of these structural components and can be prepared by different approaches to improve the therapeutic outcomes. In this chapter, we provide the useful insight about the lipid-polymer hybrid nanoparticles (LPHNPs) that can be prepared by using the different structural components including the synthetic and natural polymers and lipids. Among these, we also explain the various methods to prepare the LPHNPs with various desired characteristics. Finally, the various therapeutic and clinical applications have been presented briefly.

Biological Performances of Plasmonic Biohybrids Based on Phyto-Silver/Silver Chloride Nanoparticles

“…Nowadays, the use of natural resources and, in particular, plants has experienced a great importance, thanks to the impressive number of bioactive ingredients with a strong beneficial impact on human health. The intensive development of new hybrid lipid–nanoparticle complexes, including inorganic nanoparticles (NPs), lipid assemblies, and lipid–polymer complexes, is caused by numerous potential biomedical applications [ 1 , 2 ]. Soy lecithin liposomes represent a promising drug delivery system, especially in the fight against serious illnesses such as tuberculosis and malaria [ 3 ].…”

Drug Delivery Nanosystems in Glioblastoma Multiforme Treatment: Current State of the Art

“…HN can also improve the release profile and bioavailability of some drugs that haven’t possess good in vitro properties in isolated polymeric nanoparticles or liposomes. As happens for lipid and polymer-based systems isolated, HN can be combined with one or more ligands to promote active targeting and assist in the BBB penetration [ 110 , 113 , 114 ]. For example, among the works about functionalized polymeric systems loaded with PTX, in vivo tests showed that micelles presented the highest survival rate (48 days), followed by hybrid nanoparticles (42 days) and polymeric nanoparticles (nanocapsules: 34 days and nanospheres: 28 days) [ 47 , 64 , 72 , 83 ] demonstrating that systems that exhibited particle size less than 100 nm and those that have a lipid phase in their composition showed better biological performance in reaching the tumor for PTX delivery, increasing the survival rates of animal models with GBM.Dox was encapsulated in cRGD-targeted hybrid nanoparticles (cRGD-HN-Dox).…”

Utilization of Polymer-Lipid Hybrid Nanoparticles for Targeted Anti-Cancer Therapy

“…Thus, by combining the superiority of receptor overexpression with an uncommon binding motif, LPHNPs can be functionalized with different ligands to preferentially bind to the receptors via ligand-receptor interaction at the cell surface [ 67 ]. The ligand-engineered hybrid NPs are internalized by cancer cells via receptor-mediated endocytosis with a higher affinity towards the targeted tissues and a lower affinity towards the healthy tissues [ 68 ]. LPHNPs are functionalized by adding different ligands to the end of the PEG chain through covalent bond formation (amide-based reactions) or click chemistry.…”

“…The short life of siRNA was increased and resulted in tumor eradication in the orthotopic tumor model [ 138 ]. All the above studies demonstrate that PLHNPs are appropriate vectors for drug delivery because of their stability, long life, and biodegradable properties [ 68 ].…”