Lipid presentation by human CD1 molecules and the diverse T cell populations that respond to them

Adams, Erin J.

doi:10.1016/j.coi.2013.09.005

Cited by 40 publications

(39 citation statements)

References 35 publications

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“…Uldrich et al demonstrated reactivity to the microbial lipid α-GalCer, and even though the affinity and reactivity to this lipid was much less than that observed in the case of iNKT cells (16 μM compared to 0.5 μM, and evidenced by lower tetramer staining intensity to Vδ1 cells than iNKT cells), it sets an important precedent that microbial lipids may be stimulatory. Directly relevant to sulfatide reactivity, some pathogens, such as Trypanosoma cruzi [42] and Mycobacterium tuberculosis [43], can produce sulfatide-like compounds, and it is also likely that other bacterial species and stressed cells make antigens that can be presented by CD1 molecules to these γδ T cells ([44] and reviewed in [45]).…”

Section: Towards a More Global Understanding Of γδ T Cell Activationmentioning

confidence: 99%

γδ T cell surveillance via CD1 molecules

Luoma

Castro

Adams

2014

Trends in Immunology

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γδ T cells are a prominent epithelial-resident lymphocyte population, possessing multi-functional capacities in the repair of host tissue, pathogen clearance, and tumor surveillance. Although three decades have now passed since their discovery, the nature of γδ TCR-mediated ligand recognition remains poorly defined. Recent studies have provided structural insight into this recognition, demonstrating that γδ T cells survey both CD1 and the presented lipid, and in some cases are exquisitely lipid specific. We review these findings here, examining the molecular basis for and the functional relevance of this interaction. We discuss potential implications on the notion that non-classical MHC molecules may function as important restricting elements of γδ TCR specificity, and on our understanding of γδ T cell activation and function.

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Section: Towards a More Global Understanding Of γδ T Cell Activationmentioning

confidence: 99%

γδ T cell surveillance via CD1 molecules

Luoma

Castro

Adams

2014

Trends in Immunology

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“…Human CD1a, CD1b, and CD1c molecules are members of group I and group II is formed by CD1d. CD1a-c molecules are expressed in professional antigen-presenting cells (APCs) and are involved in the defense against microbial infections, like mycobacteria [2]. CD1d is also expressed on professional APCs including dendritic cells (DCs), macrophages (Mϕ), monocytes, and some B cells.…”

Section: Introductionmentioning

confidence: 99%

Human Invariant Natural Killer T Cells Respond to Antigen-Presenting Cells Exposed to Lipids from Olea europaea Pollen

Gracia

López-Relaño²,

Revilla³

et al. 2017

Int Arch Allergy Immunol

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Background: Allergic sensitization might be influenced by the lipids present in allergens, which can be recognized by natural killer T (NKT) cells on antigen-presenting cells (APCs). The aim of this study wasto analyze the effect of olive pollen lipids in human APCs, including monocytes as well as monocyte-derived macrophages (Mϕ) and dendritic cells (DCs). Methods: Lipids were extracted from olive (Olea europaea) pollen grains. Invariant (i)NKT cells, monocytes, Mϕ, and DCs were obtained from buffy coats of healthy blood donors, and their cell phenotype was determined by flow cytometry. iNKT cytotoxicity was measured using a lactate dehydrogenase assay. Gene expression of CD1A and CD1D was performed by RT-PCR, and the production of IL-6, IL-10, IL-12, and TNF-α cytokines by monocytes, Mϕ, and DCs was measured by ELISA. Results: Our results showed that monocytes and monocyte-derived Mϕ treated with olive pollen lipids strongly activate iNKT cells. We observed several phenotypic modifications in the APCs upon exposure to pollen-derived lipids. Both Mϕ and monocytes treated with olive pollen lipids showed an increase in CD1D gene expression, whereas upregulation of cell surface CD1d protein occurred only in Mϕ. Furthermore, DCs differentiated in the presence of human serum enhance their surface CD1d expression when exposed to olive pollen lipids. Finally, olive pollen lipids were able to stimulate the production of IL-6 but downregulated the production of lipopolysaccharide- induced IL-10 by Mϕ. Conclusions: Olive pollen lipids alter the phenotype of monocytes, Mϕ, and DCs, resulting in the activation of NKT cells, which have the potential to influence allergic immune responses.

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“…21 Therefore, 3 processing and presentation mechanisms have been characterized: (1) the exogenous (or endosomal) pathway, where antigenic peptides are generated and coupled to MHC-II molecules in phagolysosomes and then transported to the cell surface and presented to CD4 1 T cells; (2) the endogenous (or proteasome) pathway, where the intracellular proteins are degraded by the proteasome, and the resulting peptides are coupled to MHC-I molecules in the Golgi and then transported to plasma membrane and presented to CD8 1 T cells; and (3) mechanisms where lipid antigens are coupled to CD1 family molecules and presented to CD8 1 T cells, g/d T cells, or NK T cells. 22 Exogenous antigens can also be presented to CD8 1 T cells via MHC-I complexes, a process termed crosspresentation. In cross-presentation, internalized proteins are retrotranslocated into the cytosol and degraded by the proteasome.…”

Section: Q10mentioning

confidence: 99%