Lipid Profile and Hematological Changes in Gallstone Patients

Rasheed, Rezhna Adil

doi:10.25271/2014.2.1.132

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…Any abnormal function of lipid metabolism might arise from combination of different factors like high calorie diet, diabetes, obesity, drugs for example oral contraceptives and importantly, genetic predispositions. 16 Metabolic factors are in relation to cholesterol solubility in bile acids. Bile acids are formed in the liver from cholesterol.…”

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Physiological effect of cholecystectomy on lipid profile of patients with cholelithiasis

et al. 2020

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Background: The association of cholecystectomy with alterations in lipid profile is well documented. Objectives of this study were to determine the effect of cholecystectomy on lipid profile of cholelithiasis patients.Methods: This cross-sectional observational study was done on 170 patients admitted in general surgery department of Naz Memorial Hospital, Karachi from July 2018 to June 2019. Symptomatic cholelithaisis patients between 18 to 60 years, elective cholecystectomy was included while patients previously on lipid lowering agents, diagnosed renal failure, nephrotic syndrome, cardiac failure, pregnant mothers, hypothyroidism, pancreatitis and obstructive jaundice were excluded. For data analysis, SPSS was used. Wilcoxon signed ranked test was used to compare mean values of pre and post-operative lipid profiles after cholecystectomy keeping p value of <0.05 as significant. Results: 60% of patients were females with majority, 31% patients between 31-40 years while least, i.e. 11% were between 61-70 years. The mean pre-operative and post-operative difference of 52±7.32 mg/dl was seen in total cholesterol levels (p<0.001). The mean difference in high density lipoprotein (HDL) between pre and post-operative was of 13±0.36 mg/dl (p<0.001). The mean difference in low density lipoprotein (LDL) between pre- and post-operative was 61±10.45 mg/dl (p<0.001). The mean difference in triglycerides levels between pre- and post-operative was 46±25.49 mg/dl (p<0.001).Conclusions: Cholecystectomy in gall stone disease patients elicited favorable response in significantly lowering levels of total serum cholesterol, LDL and triglycerides while substantially increasing levels of HDL cholesterol.

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Physiological effect of cholecystectomy on lipid profile of patients with cholelithiasis

et al. 2020

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Attenuation of Experimental Cholesterol Gallstone Formation by Manganese Chloride in Mice: Role of NF-κβ Pathways

Salami,

Orji,

Akpamu

et al. 2024

Biol Trace Elem Res

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Attenuation of Experimental Cholesterol Gallstone Formation by Manganese Chloride in Mice: Role of Nfκβ Pathways

T.,

Orji,

Akpamu

et al. 2024

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Manganese (Mn) a trace element, has been documented to exert important role in the metabolism of cholesterol. Cholesterol gallstone (CG) pathogenesis is directly linked to biliary cholesterol imbalance which could be due to diabetes complication or mis-management. NF-κB pathway, an inflammatory regulator has been implicated in metabolic disease especially during diabetes and gallstone. However, management of cholesterol gallstone due to diabetes with trace element is vague. This study investigates the probable role of Manganese during cholesterol gallstone formation due to diabetes complications. 80 Female Swiss mice were grouped thus: I (control), II (Untreated-CG), III and IV (normal mice treated 0.37mg/kg and 0.74mg/kg Mn respectively), V and VI (CG treated 0.37mg/kg and 0.74mg/kg Mn respectively), and VII and VIII (CG treated 75mg/7kg and 350mg/kg aspirin respectively). Experimental CG was induced with cholesterol-rich diets after alloxan-induced diabetes. On sacrifice, blood collected was evaluated for complete haematological analysis and biochemistry while excised liver was assayed for biochemical variables. Results were subjected to one-way ANOVA values were expressed as Mean ± SEM and significant at p ≤ 0.05. Manganese treatment significantly increased packed cell volume, RBC count and haemoglobin with decreased platelet and leukocyte counts, liver enyzmes (AST, ALT and ALP), BUN and creatinine levels in CG groups compared with untreated-CG. Blood glucose, plasma Low Density Lipoproteins and liver malodialdehyde levels were significantly reduced while Liver nitric-oxide, sulfhydryl and glutathione levels increased significantly in Manganese-treated groups compared with untreated-CG. Manganese significantly increased feacal iron contents in normal mice by the 2nd week. Hepatocytes and gallbladder histology appear normal in Manganese-treated groups. Liver NF-Kβ immunoreactivity was downregulated in Manganese-treated CG groups. Manganese attenuated experimental hyperglycemia induced cholesterol gallstone by ameliorating liver oxidative stress and NF-Kβ inflammatory pathway.

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Lipid Profile and Hematological Changes in Gallstone Patients

Cited by 3 publications

References 9 publications

Physiological effect of cholecystectomy on lipid profile of patients with cholelithiasis

Physiological effect of cholecystectomy on lipid profile of patients with cholelithiasis

Attenuation of Experimental Cholesterol Gallstone Formation by Manganese Chloride in Mice: Role of NF-κβ Pathways

Attenuation of Experimental Cholesterol Gallstone Formation by Manganese Chloride in Mice: Role of Nfκβ Pathways

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