Lipid Profile and Hepatic Enzymes Differences between Pre-diabetes and Normal Staff

Kushkestani, Mehdi; Parvani, Mohsen; Nosrani, Shiva Ebrahimpour; Rezaei, Sohrab; Karimi, Maryam

doi:10.17265/2332-7839/2020.02.005

Cited by 1 publication

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Extensive studies have shown that obesity increases the risk of chronic diseases, such as cancer, cardiovascular disease, stroke (the leading cause of death worldwide), diabetes and its complications, and musculoskeletal disorders (e.g. osteoarthritis) (2)(3)(4)(5). Type 2 diabetes (T2D) is a metabolic disease caused by a gradual decrease in insulin secretion or the inability of the body to respond to insulin.…”

Section: Introductionmentioning

confidence: 99%

“…T2D was also responsible for 1.5 million direct deaths in 2019 (7). T2D is associated with various complications and disorders, such as vision problems (retinopathy), atherosclerosis, neurological diseases, kidney diseases (nephropathy), heart diseases, stroke, and finally death (5,8,9). The fat mass and obesity-associated (FTO) gene is associated with the development of obesity and related diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of six-week high-intensity interval training on muscle expression of FTO and PPAR-γ in obese diabetic rats

Kushkestani¹,

Parvani²,

Moghadassi³

et al. 2022

JHS

View full text Add to dashboard Cite

Background and purpose: Recent research suggests that obese people are up to 80 times more likely to develop type 2 diabetes than those with a normal BMI. Besides, obesity, inadequate physical activity, and unhealthy diets are the main causes of this metabolic disease. The purpose of this study was to investigate the effect of six weeks of high-intensity interval training on muscle expression of Fat mass and obesity-associated protein (FTO) and Peroxisome proliferator activator receptor gamma (PPAR-γ) in obese diabetic rats. Material and methods: This experimental study was carried out on 12 male Wistar rats (220±20 g bodyweight and 10 weeks old). Animals received a high-fat diet within six weeks, and then in order to induce type 2 diabetes, an intraperitoneal injection of a single dose of 30 mg/kg freshly prepared streptozotocin (STZ) (Sigma, USA) solved in citrate buffer (pH 4.5) was performed. Diabetic rats were divided into two (High-Intensity Interval Training and control) groups randomly. HIIT program included five sessions of 30 minutes per week. 48 hours after the last training session, the outcomes were measured. The muscle expression of FTO and PPAR-γ was measured using the real-time PCR method. Independent samples t-test and Analysis of covariance (ANCOVA) were applied to compare the means. Results: The expression of FTO (P<0.01), fasting blood sugar (P<0.001), weight (P<0.001) and HOMA-IR (P<0.004) significantly decreased after six weeks of high-intensity interval training, whilst PPAR-γ expression (P<0.007) significantly increased. Conclusion: Regarding the results of this study, it can be stated that a six-week HIIT program can improve glucose metabolism and insulin sensitivity. It can also increase the expression of diabetes- and obesity-associated genes (e.g., PPAR-γ and FTO), and thereby plays a prominent role in the control and treatment of type 2 diabetes in obese patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%