Lipid profile and its correlation with C-reactive protein in patients of acute myocardial infarction

Abstract

INTRODUCTIONAcute myocardial infarction (AMI), commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cells to die. This is most commonly due to occlusion of a coronary artery following the rupture of a vulnerable atherosclerotic plaque which is an unstable collection of lipids (cholesterol and fatty acids) and white blood cells (especially macrophages) in the wall of an artery. The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death (infarction) of heart muscle tissue (i.e. myocardium). 1,2Acute myocardial infarction (AMI) continues to be a major cause of morbidity and mortality worldwide.3,4 It remains a leading cause of death in India and represents an enormous cost to health care system. 5 The mortality rate of MI is approximately 30% and for every 1 in 25 patients who survive the initial hospitalization, dies in the first year after AMI. Indians are four time more prone to AMI as compared to the people of other countries due to a combination of the genetic and lifestyle factors that promote metabolic dysfunction. The risk of ABSTRACT Background: Acute myocardial infarction (AMI) is a significant cause of morbidity and mortality worldwide, which results from occlusion of coronary artery. Dyslipidemia is a major risk factor of AMI. C-reactive protein (CRP) is an acute phase protein, synthesized by hepatocytes in response to cytokines released into circulation by activated leukocytes and has been found to increase after AMI. The objective of the present study is to investigate lipid profile in AMI patients and correlate it with inflammatory marker i.e. CRP. Methods: The present study includes 150 AMI patients and 100 normal healthy individuals as controls. In all the cases and controls, serum lipid profile and inflammatory marker were measured by diagnostic kits supplied by ERBA. Results: The levels of lipid profile and inflammatory marker were significantly altered in the AMI cases compared to controls. We found significantly higher levels of total cholesterol, TG, LDL, VLDL, CRP and lower level of HDL in AMI compared to that of control subjects. We also found strong positive correlation of CRP with total cholesterol, triglyceride, LDL-C and VLDL-C and significant negative correlation with HDL-C in AMI patients. Conclusions: We found alterations in the lipid profile and inflammatory marker in AMI cases; hence, all the people should undergo regular check up including lipid profile evaluation and inflammatory marker such as CRP to decrease the incidence, morbidity and mortality from the disease.

Effect of Giving Black Seed (Nigella Sativa L) On Il-10 Levels, And CRP Levels (Experimental Study on Wistar Strain Male White Rats Induced By A High Fat Diet)

“…Thymoquinone inhibits NO production by reducing the expression of inducible nitric oxide synthase (iNOS), 29 and from the NFκB pathway, thymoquinone inhibits the nuclear expression of the P65 NFκB subunit and the binding of the P50 subunit to the TNF-α promoter. 30 This study's results are similar to previous studies that thymoquinone improves oxidative stress. Moreover, reduces the inflammatory response by reducing TNF-α and increasing levels.…”

Serum high sensitive C-reactive protein level and its correlation with lipid profile among dyspeptic patients in East Gojjam Zone, Ethiopia

“…Analogous research and reviews demonstrating this correlation have been published in different countries (20)(21)(22)(23). This could be because a variety of lipid species, such as sterols, complex lipids, lipoproteins, fatty acids, and their metabolites have been shown to have immunomodulatory and proand anti-in ammatory qualities (24).…”

Correlation Between C-Reactive Protein and Blood Sugar Profile and Lipid Profile in Obesity After Lifestyle Modification for 3 Months

“…We also found a strong positive correlation of CRP with total cholesterol, triglyceride, LDL-C, and VLDL-C and a significant negative correlation with HDL-C in AMI patients. [16] A significant positive correlation of inflammatory marker hs CRP was observed with fasting blood sugar, serum cholesterol, and LDL-cholesterol. On the other hand, a non-significant negative correlation between inflammatory markers was observed with serum HDL cholesterol and triglycerides.…”