Lipid profile and left ventricular geometry pattern in obese children

Bjelaković, Bojko; Stefanutti, Claudia; Vuković, Vladimir; Kavarić, Nebojša; Šaranac, Ljiljana; Klisić, Aleksandra; Lukic, Stevo; Stanković, Sanja; Jović, Maja; Prijić, Sergej; Bjelaković, Marko; Banach, Maciej

doi:10.1186/s12944-020-01285-9

Cited by 18 publications

(14 citation statements)

References 39 publications

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“…These findings have renewed interest of the scientific community in the study of adipose tissue distribution and its relative effect on health 11,12 . Previous studies in adolescents have shown that central adiposity was more closely associated with the risk of T2DM than general adiposity 13,14,15 . In a study of Chinese adolescents aged 13-15 years 10 , participants with abdominal OB as measured by waist-to-height ratio (WHtR) were found to have significantly higher fasting blood glucose (FBG) compared to their non-obese peers.…”

Section: Introductionmentioning

confidence: 94%

Diagnostic performance of central and generalized adiposity in detecting risk of diabetes mellitus in adolescents

Musa¹,

Agbana²,

Adeola³

et al. 2022

Afr H. Sci.

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Background: The prevalence of type 2 diabetes mellitus (T2DM) is increasing in all age groups, including the adolescent globally. Objective: This study examined the association of adiposity with the risk of T2DM in adolescents aged 11 to 19 years. Methods: This study comprised 403 adolescent boys (202) and girls (201). Participants were assessed in three indices of body fat and fasting blood glucose (FBG). Multivariate regression models assessing the associations of the independent variables with risk of T2DM were conducted. Receiver operating characteristic curve (ROC) analysis was used to determine the predictive capacities of the body fat proxies to detect risk of T2DM. Results: The prevalence of glucose abnormalities was 13.6% and 1.8% for pre-diabetes and diabetes respectively. Among the body fat indices in boys, WHtR was the only independent predictor ( =0.599, p<0.001) of T2DM risk. Both the WHtR and WC had significant (p<0.001) Areas under curve (AUC), with WHtR as the best body fat indicator for identifying risk of T2DM in boys. The independent variables had no discriminatory capacities to detect T2DM risk in girls. Conclusions: This study has demonstrated that central fat is more important than total fat in detecting risk of T2DM in Nigerian adolescent boys. Keywords: Abdominal obesity; adolescents; anthropometry; ROC curve; T2DM.

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Section: Introductionmentioning

confidence: 94%

Diagnostic performance of central and generalized adiposity in detecting risk of diabetes mellitus in adolescents

Musa¹,

Agbana²,

Adeola³

et al. 2022

Afr H. Sci.

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“…However, some studies failed to find a significant correlation between LVH and any other laboratory parameters such as blood lipids 14,15 . At present, there is only evidence supporting that an increased TG/HDL‐C ratio (representing the level of insulin resistance) in people with obesity is related to the development of eccentric LVH 16 . Recent studies have found LVH to be more common in women than in men (43% versus 32%), suggesting that there may be gender differences in the incidence of LVH 17 .…”

Section: Introductionmentioning

confidence: 99%

“…14,15 At present, there is only evidence supporting that an increased TG/HDL-C ratio (representing the level of insulin resistance) in people with obesity is related to the development of eccentric LVH. 16 Recent studies have found LVH to be more common in women than in men (43% versus 32%), suggesting that there may be gender differences in the incidence of LVH. 17 Therefore, it is necessary to explore the impacts of traditional and nontraditional dyslipidemia on LVH among the Chinese general population.…”

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confidence: 99%

Combined superposition effect of hypertension and dyslipidemia on left ventricular hypertrophy

Zhang

Shi

et al. 2022

Anim Models and Exp Med

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Background Hypertension and dyslipidemia are considered reversible risk factors for cardiovascular disease. The purpose of this study was to explore the impact of traditional and nontraditional blood lipid profiles on the risk of left ventricular hypertrophy (LVH) and to explore the superposition effect of dyslipidemia combined with hypertension. Methods Data on 9134 participants (53.5 ± 10.3 years old) from the Northeast China Rural Cardiovascular Health Study (NCRCHS) were statistically analyzed. The blood lipid profile was measured by total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), total glyceride (TG), and calculated nontraditional blood lipid indices including non‐HDL‐C, atherosclerosis index (AI), TC/HDL‐C, and residual cholesterol (RC). Results After the adjustment of age and gender, the odds ratios (ORs) of LVH in patients with hypertension, high LDL‐C, high non‐HDL‐C, high AI, and high TC/HDL‐C were 3.97 (3.31–4.76), 1.27 (1.02–1.59), 1.21 (1.04–1.39), 1.33 (1.15–1.53), and 1.42 (1.22–1.65), respectively. After full adjustment of potential confounding factors, high AI and TC/HDL‐C were associated with LVH rather than traditional blood lipid indices. The combination of hypertension and nontraditional dyslipidemia (defined by high AI and TC/HDL‐C) was associated with the highest risk of LVH, especially in participants under 45 years of age. The risk was more significant in men, 5.09‐fold and 6.24‐fold, respectively, compared with 3.66‐fold and 4.01‐fold in women. Conclusions People with dyslipidemia defined by nontraditional blood lipid indices (high AI and high TC/HDL‐C) and hypertension were more likely to develop LVH.

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“…It is well known that there is a potential link between dyslipidemia and obesity, and symptoms of dyslipidemia include decreased HDL and increased TG. Also LDL can affect blood pressure by increasing aldosterone [ 9 , 10 ]. The prevalence of hypertension in children and adolescents in developing countries has been reported to be between one and five percent through systematic review [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Measurement of Urinary Triclocarban and 2,4‐Dichlorophenol Concentration and Their Relationship with Obesity and Predictors of Cardiovascular Diseases among Children and Adolescents in Kerman, Iran

Nasab

Mirzaee

Hashemi

et al. 2022

Journal of Environmental and Public Health

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Exposure to Endocrine-Disrupting Chemicals (EDCs) at an early age can lead to chronic diseases. 2,4-Dichlorophenol (2,4-DCP) and Triclocarban (TCC) are among EDCs that disrupt the endocrine system and alter the body's metabolism. In the present study, the hypothesis that exposure to 2,4-DCP and TCC affects obesity and predictors of cardiovascular diseases was investigated. Fasting Blood Sugar (FBS), Total Cholesterol (TC), Triglyceride (TG), Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL (tests were performed on 79 children and adolescents. Also, blood pressure, Body Mass Index (BMI), and BMI z-score were measured to examine the hypothesis. Urinary concentrations of TCC and 2,4-DCP were measured by Gas Chromatography-Mass Spectrometry (GC/MS). Mean concentrations of TCC and 2,4-DCP (µg/L) were higher in obese individuals (5.50 ± 2.35, 0.29 ± 0.13, respectively). After adjusting for possible confounding factors, the results showed an increase in TCC concentration among girls and a decrease in 2,4-DCP among boys with increasing age. The 2,4-DCP concentration among girls increased by 0.007 and 0.01 units with a one-unit increase in Diastolic Blood Pressure (DBP) and FBS, respectively. There was a significant relationship between TCC and TG (Odds Ratio (OR) = 1.02, p -value = 0.007), LDL (OR = 1.05, p -value = 0.003), and HDL (OR = 0.88, p -value = 0.002). There was also a significant relationship between 2,4-DCP and TG (OR = 1.02, p -value = 0.002), LDL (OR = 1.12, p -value = 0.007), and HDL (OR = 0.92, p -value = 0.02). Exposure to TCC and 2,4-DCP can increase some heart risk factors and increase the risk of cardiovascular diseases and obesity. However, to confirm the results of the present study, it is necessary to conduct further studies, such as cohort and case-control studies, with a larger sample size to examine the causal relationships.

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Lipid profile and left ventricular geometry pattern in obese children

Cited by 18 publications

References 39 publications

Diagnostic performance of central and generalized adiposity in detecting risk of diabetes mellitus in adolescents

Diagnostic performance of central and generalized adiposity in detecting risk of diabetes mellitus in adolescents

Combined superposition effect of hypertension and dyslipidemia on left ventricular hypertrophy

Measurement of Urinary Triclocarban and 2,4‐Dichlorophenol Concentration and Their Relationship with Obesity and Predictors of Cardiovascular Diseases among Children and Adolescents in Kerman, Iran

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