Lipid profile atherogenic indeces and their relation of epicardial fat thickness and carotid intima media thickness in Celiac disease

Abstract

OBJECTIVE:In this study, we aimed to investigate the presence of subclinical atherosclerosis by measuring epicardial fat thickness (EFT) and carotid intima–media thickness (cIMT), evaluate low-level inflammation with high-sensitivity C-reactive protein (hsCRP), and evaluate whether there is a relationship among lipid profile, atherogenic indices, and hsCRP with these subclinical atherosclerosis markers in patients with celiac disease (CD).METHODS:After exclusion and inclusion criteria were applied, 31 patients with CD (24 female, mean age: 39.4±12.3 years) and 32 healthy controls (21 female, mean age: 39.5±4.4 years), totally 63 cases, were recruited. Subclinical atherosclerosis was evaluated with EFT by transthoracic echocardiography and cIMT by ultrasonography. Inflammatory markers including erythrocyte sedimentation rate (ESR), hsCRP, and lipid profile were recorded. Also, atherogenic indices were calculated: Castelli risk index I and II (TG/HDL-c and LDL-c/HDL-c, respectively), atherogenic index of plasma (AIP; logarithm TG/HDL-c), non-HDL-c (TG-HDL-c), and atherogenic coefficient (AC; non-HDL-c/HDL-c).RESULTS:EFT was significantly higher in the CD group (0.49±0.10 vs. 0.49±0.09; p-value: 0.02). Although cIMT was higher in the patient group, it did not reach statistical significance (0.51±0.08, 0.47±0.08; p-value: 0.10). HDL cholesterol level was found to be significantly lower (42.0±8.8 vs. 50.0±13.7; p-value: 0.01), and the plasma atherogenic index was found to be significantly higher in the patient group (0.98±0.50 vs. 0.62±0.64; p-value: 0.02). hsCRP (3.51±3.18 vs. 1.92±1.40; p-value: 0.02) and ESR (17.2±12.8 with 9.7±3.1; p-value: 0.01) were found to be significantly higher in the CD group. Although there was a significant positive correlation between EFT and hsCRP (r: 0.453; p-value: 0.01), there was a significant negative correlation between cIMT and HDL-cholesterol (−0.339; p-value: 0.05), and a significant positive correlation with the other components of the atherogenic index was found.CONCLUSION:The risk of atherosclerosis has been increased in patients with CD. Chronic inflammation may be responsible for this increase along with atherogenic indices.

Exploring celiac disease candidate pathways by global gene expression profiling and gene network cluster analysis

“…APOA1 is the major component of highdensity lipoprotein (HDL) which is strongly associated with coronary heart disease (CHD) 59,60 . Both low HDL levels and risk of CHD have been reported in CeD patients 61 . GO annotations of the second cluster includes drug metabolism, metal ion homeostasis, lipid and other molecules transportation.…”

Relationship between testosterone-estradiol ratio and some anthropometric and metabolic parameters among Nigerian men

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Occurrence of MTHFR C677T gene polymorphism and its association with atherogenic indices in Mexican women from San Luis Potosi, a preliminary study

“…The ndings indicated that AIP is a reliable prognostic CVD biomarker in middle-aged adults (Onat et al 2010). Furthermore, AIP has been associated with validated biomarkers of subclinical atherosclerosis, such as the intima-media thickness of the carotid artery (cIMT), asymmetric dimethylarginine (ADMA), insulin resistance, the ratio of apolipoprotein B (apoB): apolipoprotein A-1 (apoA1), among others (Tongdee and Nimkuntod 2016;Cure et al 2018;Caliskan et al 2019;Fernandez-Macias et al 2019;Tecer et al 2019).…”