Lipid profile in adult patients with idiopathic juvenile arthritis

Skare, Thelma Larocca; Silva, Marilia Barreto; Negreiros, Paulo

doi:10.1016/s2255-5021(13)70052-x

Cited by 5 publications

(6 citation statements)

References 16 publications

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“…The identi cation of cardiovascular risk in the pediatric age group is a major challenge, especially in patients with chronic conditions such as JIA [9] . Measurements of the medial-intimal thickness (MIE) and biomarkers of lipid metabolism have been proposed as mechanisms for achieving this [10][11][12][13] . In adult patients with rheumatoid arthritis, changes in apolipoprotein B (Apo B) concentrations and the Apo B/apolipoprotein A-I (Apo A-I) ratio compared to those in the classical lipid pro le have been independently associated with cardiovascular risk [14] .…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with subtype and inflammatory activity

Rodrigues

Sarni

Fonseca

et al. 2020

Preprint

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Background: To describe the biomarkers of lipid metabolism in children and adolescents with polyarticular and systemic JIA and to relate them to diseases subtypes, diseases activity markers, and nutritional status. Methods: A cross-sectional study including 62 JIA patients was performed. The following variables were evaluated: disease activity and medications used, body mass index, height for age (z-score), skin folds (bicipital, tricipital, subscapular and suprailiac), food intake based on three 24-hour food recalls, lipid profile (total cholesterol (CT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG) and non-HDL (N-HDLc), glycemia and insulin, erythrocyte sedimentation rate (ESR), ultrasensitive C-reactive protein (us-CRP) and apolipoproteins A-I and B (Apo A-I and Apo B).Results: Dyslipidemia was observed in 83.3% of the patients. Based on classical lipid profile, low HDL-c levels was the most frequently alteration observed. Inadequate levels of LDL-c, Apo B and NHDL-c were significantly more frequent in the systemic JIA subtype when compared to the polyarticular subtype (p = 0.017, 0.001 and 0.042 respectively). Patients on biological therapy had a better adequacy of Apo A-I concentrations. The ESR showed a negative correlation with Apo A-I level (r = -0.25, p = 0.047).Conclusion: We concluded that dyslipidemia is common in patients with JIA, especially in systemic subtype. The systemic subtype and an elevated ESR were associated with lower concentrations of Apo A-I, suggesting the participation of the inflammatory process.

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Section: Introductionmentioning

confidence: 99%

Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with subtype and inflammatory activity

Rodrigues

Sarni

Fonseca

et al. 2020

Preprint

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“…In recent years, many studies have reported that compared with healthy children, children with JIA have blood fat metabolism disorders [ 33 ]. Current studies suggest that the inflammatory state and overexpression of proinflammatory cytokines caused by immune disorders in children with JIA at the active stage may lead to lipid metabolism disorders [ 34 ]. Chronic systemic inflammation in JIA patients can also induce changes in the structure and level of lipoproteins.…”

Section: Discussionmentioning

confidence: 99%

Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysis

Zhao,

Deng,

2023

Lipids Health Dis

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Objective The purpose of this study was to comprehensively evaluate the lipid profiles in patients with juvenile idiopathic arthritis (JIA). Methods The literature and relevant reviews were searched for published clinical studies on the relationship between JIA and blood lipid levels. The Newcastle–Ottawa scale (NOS) was applied to evaluate the risk and methodological value of the included case‒control and cohort studies. Standardized mean differences (SMDs) and 95% confidence intervals were derived for all variables with adequate unprocessed data. This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Results In total, 16 studies were incorporated through screening. The analysis findings revealed that the levels of very low-density lipoprotein cholesterol [SMD=-0.411, 95% CI (-0.774~-0.048), P = 0.026], high-density lipoprotein cholesterol [SMD=-0.528, 95% CI (-0.976~-0.079), P = 0.021], and apolipoprotein A1 [SMD=-1.050, 95% CI (-1.452~-0.647), P = 0.000] in JIA patients were statistically lower than those observed in healthy controls. The level of low-density lipoprotein cholesterol [SMD = 0.202, 95% CI (0.003 ~ 0.400), P = 0.046] was significantly higher in JIA patients than in healthy controls. In JIA patients, body mass index [SMD=-0.189, 95% CI (-0.690 ~ 0.311), P = 0.459], high-density lipoprotein [SMD =-1.235, 95% CI (-2.845 ~ 0.374), P = 0.133), low-density lipoprotein [SMD = 0.616, 95% CI (-0.813 ~ 2.046), P = 0.398), triglycerides (SMD = 0.278, 95% CI (-0.182 ~ 0.738), P = 0.236], total cholesterol [SMD=-0.073, 95% CI (-0.438 ~ 0.293), P = 0.696] and apolipoprotein B levels [SMD = 0.226, 95% CI (-0.133 ~ 0.585), P = 0.217] were not significantly different from those in healthy controls. Conclusions The outcomes of this meta-analysis suggest that dyslipidemia is common in JIA patients compared to healthy controls. Patients with JIA have a significantly increased risk of atherosclerosis and cardiovascular disease later in life.

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“…Studies evaluating non-classical biochemical markers related to lipid metabolism in children and adolescents with autoimmune rheumatic diseases are scarce [12,22,[24][25][26].…”

Section: Fig 1 Correlation Between Levels Of Erythrocyte Sedimentation Rate and Apolipoprotein A-i In Children And Adolescents With Juvenmentioning

confidence: 99%

“…The identification of cardiovascular risk in the pediatric age group is a major challenge, especially in patients with chronic conditions such as JIA [9]. Measurements of the medial-intimal thickness (MIE) and biomarkers of lipid metabolism have been proposed as mechanisms for achieving this [10][11][12][13]. In adult patients with rheumatoid arthritis, changes in apolipoprotein B (Apo B) concentrations and the Apo B/apolipoprotein A-I (Apo A-I) ratio were compared to those in the classical lipid profile have been independently associated with cardiovascular risk [14].…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with disease subtype and inflammatory activity

et al. 2021

View full text Add to dashboard Cite

Background To describe the biomarkers of lipid metabolism in children and adolescents with polyarticular and systemic JIA and to relate them to diseases subtypes, diseases activity markers, and nutritional status. Methods A cross-sectional study including 62 JIA patients was performed. The following variables were evaluated: disease activity and medications used, body mass index, height for age (z-score), skin folds (bicipital, tricipital, subscapular and suprailiac), food intake based on three 24-h food recalls, lipid profile (total cholesterol (CT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG) and non-HDL (N-HDLc), glycemia and insulin, erythrocyte sedimentation rate (ESR), ultrasensitive C-reactive protein (us-CRP) and apolipoproteins A-I and B (Apo A-I and Apo B). Results Dyslipidemia was observed in 83.3% of the patients. Based on classical lipid profile, low HDL-c levels was the most frequently alteration observed. Inadequate levels of LDL-c, Apo B and NHDL-c were significantly more frequent in the systemic JIA subtype when compared to the polyarticular subtype (p = 0.017, 0.001 and 0.042 respectively). Patients on biological therapy had a better adequacy of Apo A-I concentrations. The ESR showed a negative correlation with Apo A-I level (r = − 0.25, p = 0.047). Conclusion We concluded that dyslipidemia is common in patients with JIA, especially in systemic subtype. The systemic subtype and an elevated ESR were associated with lower concentrations of Apo A-I, suggesting the participation of the inflammatory process.

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Lipid profile in adult patients with idiopathic juvenile arthritis

Cited by 5 publications

References 16 publications

Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with subtype and inflammatory activity

Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with subtype and inflammatory activity

Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysis

Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with disease subtype and inflammatory activity

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