Lipid Profile in Subclinical Hypothyroidism: A Two Centers Experience

Qasim, Bayar; Mohammed, Ayad Ahmad; Ahmed, Mazyar Jabbar

doi:10.31386/dmj.2019.13.1.6

Cited by 8 publications

(6 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of studies have reported that SCH is associated with increased risk of coronary heart diseases and results in significant increase in cluster of cardiometabolic risk factors. [13,14] Similar to earlier studies, we also found preponderance of cardiometabolic risk factors in subjects with SCH in comparison to euthyroid subjects. In subjects with SH, there is a significant increase in diastolic blood pressure, total, and LDL cholesterol as well as fasting blood sugar levels.…”

Section: Discussionsupporting

confidence: 91%

Cardiometabolic and Hematological Consequences of Subclinical Hypothyroidism – A Hospital-based Study

Saha

Choudhuri

2022

APJHS

View full text Add to dashboard Cite

Introduction: Cardiometabolic syndrome is a major public health problem that effects various groups of population world over. Overt hypothyroidism is reported to be associated with both adverse cardiometabolic events as well as hematological picture. However, cardiometabolic and hematological consequences of subclinical hypothyroidism (SCH) are yet to be evaluated in different population. In the present study, we evaluated cardiometabolic and hematological consequences of SCH in a middle aged population from Agartala, Tripura, India. Methodology: The study was conducted on 193 patients attending the ENT OPD of Tripura Medical College and Dr. B.R. Ambedkar Memorial Teaching Hospital, Hapania, Agartala. Subjects having diabetes mellitus, hypertension, patients having thyroxin, antithyroid drugs and antilipidemic drug users, established cancer patients, pregnant woman, and women receiving oral contraceptive pills were excluded from inclusion in the study. Results: The mean age of the subjects was 40.13 years, and females constituted around 65 % of total subjects. The analyses showed a significant difference the RBC count, HB concentration, and a non-significant difference in WBC count between euthyroid and hypothyroid subjects, while platelets showed no significant difference between the groups. There was a significant increase in total cholesterol level and level of LDL cholesterol as well as blood pressure, blood sugar level, and waist circumference in hypothyroid subjects in comparison to euthyroid subjects. Conclusion: The study concluded that the subjects with hypothyroidism have worse cardiometabolic parameters with alteration in lipid profile. Thyroid dysfunction affects all blood parameters except platelets. The follow-up of patients with hypothyroidism should include the complete blood count and evaluation of lipid profile and other cardiometabolic parameters.

show abstract

Section: Discussionsupporting

confidence: 91%

Cardiometabolic and Hematological Consequences of Subclinical Hypothyroidism – A Hospital-based Study

Saha

Choudhuri

2022

APJHS

View full text Add to dashboard Cite

show abstract

“…Our study also found an increase in lipid profiles (TC,TG, LDL) and decrease in (HDL) in hypothyroidism patients which agrees with an earlier study, wherein they report a high increase in LDL, TC levels in 88 women aged 20-35 years with hypothyroidism at Misan City as compared to control (14). Also result in agreement with (14) found increase in (LDL) low density lipoprotein and decrease in (HDL) HDLs are increased risks factors for cardiovascular diseases (CVD) due to endothelial dysfunction, coagulation disturbances metabolic, hormonal, and hemodynamic changes related with altered lipid profile (10). A statistical significant link observed between high blood TC, TG, LDL, and low HDL levels among patients in this study, is consistent with an earlier study (15), wherein it was reported that the increase in LDL, TC and TG of hypothyroidism may be related to secretion of thyroid hormones which in turn can have an effect on the metabolism of HDL by transfer of cholesterol ester transfer protein (CETP) from (HDL2) to very low density lipoproteins (VLDL) and TG (13) found highly increase statically (p≤0.0001) in TC, LDL while decrease in (HDL) but there is no any significant change in TG associated to control (3).…”

Section: Discussionsupporting

confidence: 89%

“…Studies have shown that that the pituitary gland secretes thyroid stimulating hormone as a result of the negative feedback process. High levels of T3/T4 exert a negative feedback on the anterior pituitary decreasing TSH secretion, while low levels of T3/T4 increase TSH serum concentrations (10).…”

Section: Discussionmentioning

confidence: 99%

An evaluation of blood glucose and lipid profile in female hypothyroidism patients in Kerbala province, Iraq

Al-Fatlawi

2022

Biomedicine

View full text Add to dashboard Cite

Introduction and Aim: Hypothyroidism is a common metabolic disorder caused by inadequate secretion of the thyroid hormone by the thyroid glands. The condition impacts various metabolic processes including glucose synthesis, lipid synthesis, mobilization and metabolic rate. This study aimed to evaluate the physiological factors associated with female hypothyroidism patients of Kerbala province of Iraq. Materials and Methods: Fifty females (35 with hypothyroidism and 15 normal) aged between 20-49 years were included in the study. Blood sample was collected from each individual and subjected to thyroid function test (TFT), lipid profile test (LPT) and fasting blood glucose (FBG). Results: The study showed a significant (P?0.001) increase in thyroid stimulating hormone (TSH) levels as compared to control. While a significant decrease was seen in thyroxin (T4) levels in comparison to controls, no significant difference was seen for triiodothyronine (T3) levels in both groups. Low?density lipoprotein (LDL), Triglycerides (TG), total cholesterol (TC) was significantly increased (P?0.001) while high density lipoprotein (HDL) was observed to significantly decrease as compared to control group. High significant elevation (P?0.001) in fasting blood glucose (FBG) was seen in patients with hypothyroidism as compared to control. Conclusion: The results obtained in this study show that hypothyroidism in females to be significantly associated with increase in dyslipidemia and blood glucose levels.

show abstract

“…Paulo et al found high prevalence (62%) of hypovitaminosis D among Brazilians with type 2 diabetes as compared to control. However, Nielsen, et al from United States did not support an association between low vitamin D levels and risk of type 2 diabetes [ 4 , [16] , [17] , [18] , [19] ].…”

Section: Discussionmentioning

confidence: 99%

Impact of vitamin D level on glycemic control in diabetes mellitus type 2 in Duhok

Salih

Rasool

Ahmed

et al. 2021

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Background Vitamin D deficiency is prevalent in most parts of the world. Its insufficiency or deficiency is implicated in bone diseases, some cancers, infectious diseases, heart disease, autoimmune and metabolic diseases including type 2 diabetes mellitus. Results The mean age of patients was 49.94 ± 9.36, while the mean age the controls was 48.95 ± 10.56. Females constituted 56.1% and males 43.9% in the cases group, while for the control group females were 54.8% and males were 43.9%. Low vitamin D levels were detected in 110 (71%) of cases and 63 (40.6%) of controls. There was a significant difference in vitamin D levels among cases and controls (p < 0.001), vitamin D level was lower among females compared to males, p < 0.001 and those living in urban areas compared to rural areas, p < 0.001, BMI and dyslipidemia had a significant effect on vitamin D levels among diabetics, p values 0.002 and < 0.001 respectively. The serum 25(OH)-D level was significantly lower in patients with poor glycemic control compared to those with good glycemic control and in patients with a diabetes duration greater than 5 years, p values < 0.001 and 0.002 respectively. No significant correlation was detected with age and smoking, p values 0.181 and 0.260 respectively. Conclusion There is a high prevalence of hypo-vitaminosis D among patients with type-2 diabetes, particularly among patients with poor glycemic control and in those with longer diabetes durations. Vitamin-D deficiency is more prevalence in females, and those living in urban areas, those with obesity and patients with dyslipidemia.

show abstract

Lipid Profile in Subclinical Hypothyroidism: A Two Centers Experience

Cited by 8 publications

References 1 publication

Cardiometabolic and Hematological Consequences of Subclinical Hypothyroidism – A Hospital-based Study

Cardiometabolic and Hematological Consequences of Subclinical Hypothyroidism – A Hospital-based Study

An evaluation of blood glucose and lipid profile in female hypothyroidism patients in Kerbala province, Iraq

Impact of vitamin D level on glycemic control in diabetes mellitus type 2 in Duhok

Contact Info

Product

Resources

About