Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin

Abstract

Background: Abnormal lipid profile is common in subjects with type 2 diabetes (T2D). Despite use of lipidlowering agents, many subjects with T2D do not achieve lipid targets. The present work aimed to assess lipid profile in a randomly selected group of adult diabetic subjects under treatment in order to determine how diabetes treatment affects blood lipid parameters levels. HbA1c level is used as a biomarker of glycaemia control achievement and treatment success in diabetic. Methods: This study was carried out as a pre-post test design study with a control group. A total of 117 diabetic subjects under treatment and 100 non-diabetics as control subjects are included in the study. TC, TG and HDL-C were measured by enzymatic methods and LDL-C was determined by Friedewald formula. Plasma glucose was measured by Glucose Oxidase method and glycated hemoglobin (HbA1c) with a radioimmunoassay. Results:The results showed that TC (p<0.001), LDLc (p<0.001) and TG (p=0.02) levels increased significantly in diabetics compared to controls. Atherogenic indices TC/HDL-C (p<0.01) and LDL-C/HDL-C (p<0.01), and blood calcium level (p<0.001) were significantly increased in diabetics than in controls. Subjects with HbA1c value >7.0% had significantly higher levels of TC (P<0.01), LDL-C (p<0.05), TC/HDL-C (p<0.01), LDL-C/HDL-C (p=0.02), TG/HDL-C (p=0.01) and calcemia (p<0.001) compared to subjects with HbA1c ≤7.0%. Conclusion: Significant difference of lipid parameters was observed in diabetics with HbA1c ≤7.0% and >7.0%. Abnormal lipid patterns and insulin resistance tend to be normalized with therapy of diabetes.

Antidiabetic Effect of Conyza Aegyptiaca (L.) Dryand Ex. Aiton Is Improved by Swimming in Rat.

“…Altered lipid parameters may lead to atherosclerosis and coronary heart disease (Kelley and Goodpaster, 1999). CT, TG and LDL-C levels are reported higher in diabetic patients compared to nondiabetic controls (Kraus et al, 2002;Akpovi et al, 2015). As in the case of blood glucose, we observed an additive effect of C. aegyptiaca and SPA in the normalization of disturbed lipid profile in diabetic rats.…”