Lipid Profile of Infected Patients Treated with Highly Active Antiretroviral Therapy in Cameroon

., L. Ngondi Judith; ., S.H.L. Etame; Fonkoua, Marie‐Christine; ., H. Yangoua; Oben, Julius Enyong

doi:10.3923/jms.2007.670.673

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…The improvement in atherogenicity indices of patients on NVP compared to EFV therapy observed in this study correlated well with the findings of Ngondi et al, (2007) and could be explained through the smaller increases in TC and LDL-c concentration in patients taking NVP compared to patients taking EFV.…”

Section: Percentage Changes In Lipid and Lipoprotein Concentrations In Various Drug Classessupporting

confidence: 87%

“…It can therefore be deduced that NVP regimen (NVP + CBV) will lead to a lower atherogenicity index thereby leading to a better reduction in CHD risk compared to EFV regimen. Contrary to this finding, however, Ngondi et al, (2007) in their study reported improvements in LDL-c/HDL-c and TC/HDL-c ratios when on d4T, 3TC and NVP combination therapy compared to EFV.…”

Section: Effect Of Gender and Cd4 Counts On Lipid And Lipoprotein Concentrationcontrasting

confidence: 59%

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Evaluation of HIV therapeutic agents on immunological, lipid and lipoprotein indices in Ghanaian HIV-1 infected patients

Quaye¹,

Owiredu²,

Amidu³

et al. 2017

J. Med. Biomed. Sci.

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HIV-1 infected patients initiating antiretroviral therapy (ART) in Ghana are placed on one of the two most commonly used non-nucleoside reverse transcriptase inhibitors (NNRTIs), nevirapine (NVP) and efavirenz (EFV), in combination with a nucleoside reverse transcriptase inhibitor backbone of either combivir (CBV) or stavudine (d4T)/lamivudine (3TC). This study sought to evaluate the effect of these therapeutic agents on weight, immunological, lipid and lipoprotein changes as well as the atherogenic indices of Ghanaian HIV-1 infected patients. This observational study was carried out at the ART clinic of the Regional Hospital, Bolgatanga in the Upper-East region of Ghana from September 2008 to September 2009 comprising 61 HIV-1 infected patients who were initiated on NVP or EFV in combination with either CBV or d4T/3TC. Out of the 61 enrolled patients, 27(44.3%) were on NVP and 34(55.7%) were on EFV. Within the NVP group, 16 (59.3%) were on CBV and 11(40.7%) on d4T/3TC whilst the EFV group had 26(76.5%) on CBV and 8 (23.5%) on d4T/3TC. Percentage changes in lipid profile components comprising total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) was assessed over the 12-month period. Percentage changes in atherogenic index expressed as TC/HDL-c and LDL-c/HDL-c was also estimated. NVP elicited a 10.2% increase in weight compared to EFV and this was associated with CBV combination use. EFV further elicited a 9.1% increase in TC, 1.2% increase in TG, 39.3% increase in LDL-c and a 4.1% increase in HDL-c which resulted in concomitant percentage increases in TC/HDL-c (22%) and LDL-c/HDL-c (47.3%). CBV as a NRTI component of EFV elicited a 4.3% increase in TC/HDL-c and a 16.6% increase in LDL-c/HDL-c compared to d4T/3TC whilst conversely, d4T/3TC elicited a 3.6% increase in TC/HDL-c and a 34.0% when used in combination with NVP. NVP combination therapy elicited improvement in weight compared to EFV combination therapy for the different categories of patients. The less atherogenic lipid profile observed in patients taking NVP in comparison to those taking EFV and the reduction in CHD risk associated with NVP + CBV combination therapy observed in this study should be factored into considerations taken when selecting the most appropriate ART regimen for treatment naïve HIV-1 infected patients.Journal of Medical and Biomedical Sciences (2016) 5(3), 13-27Keywords: HIV-1, Antiretroviral therapy, Immunological, Lipids, Atherogenic indices, Bolgatanga, Ghana

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Section: Percentage Changes In Lipid and Lipoprotein Concentrations In Various Drug Classessupporting

confidence: 87%

Section: Effect Of Gender and Cd4 Counts On Lipid And Lipoprotein Concentrationcontrasting

confidence: 59%

Evaluation of HIV therapeutic agents on immunological, lipid and lipoprotein indices in Ghanaian HIV-1 infected patients

Quaye¹,

Owiredu²,

Amidu³

et al. 2017

J. Med. Biomed. Sci.

View full text Add to dashboard Cite

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Association of HIV and ART with cardiometabolic traits in sub-Saharan Africa: a systematic review and meta-analysis

Dillon

Gurdasani

Riha

et al. 2013

International Journal of Epidemiology

173

136

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Background Sub-Saharan Africa (SSA) has the highest burden of HIV in the world and a rising prevalence of cardiometabolic disease; however, the interrelationship between HIV, antiretroviral therapy (ART) and cardiometabolic traits is not well described in SSA populations.Methods We conducted a systematic review and meta-analysis through MEDLINE and EMBASE (up to January 2012), as well as direct author contact. Eligible studies provided summary or individual-level data on one or more of the following traits in HIV+ and HIV-, or ART+ and ART- subgroups in SSA: body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TGs) and fasting blood glucose (FBG) or glycated hemoglobin (HbA1c). Information was synthesized under a random-effects model and the primary outcomes were the standardized mean differences (SMD) of the specified traits between subgroups of participants.Results Data were obtained from 49 published and 3 unpublished studies which reported on 29 755 individuals. HIV infection was associated with higher TGs [SMD, 0.26; 95% confidence interval (CI), 0.08 to 0.44] and lower HDL (SMD, −0.59; 95% CI, −0.86 to −0.31), BMI (SMD, −0.32; 95% CI, −0.45 to −0.18), SBP (SMD, −0.40; 95% CI, −0.55 to −0.25) and DBP (SMD, −0.34; 95% CI, −0.51 to −0.17). Among HIV+ individuals, ART use was associated with higher LDL (SMD, 0.43; 95% CI, 0.14 to 0.72) and HDL (SMD, 0.39; 95% CI, 0.11 to 0.66), and lower HbA1c (SMD, −0.34; 95% CI, −0.62 to −0.06). Fully adjusted estimates from analyses of individual participant data were consistent with meta-analysis of summary estimates for most traits.Conclusions Broadly consistent with results from populations of European descent, these results suggest differences in cardiometabolic traits between HIV-infected and uninfected individuals in SSA, which might be modified by ART use. In a region with the highest burden of HIV, it will be important to clarify these findings to reliably assess the need for monitoring and managing cardiometabolic risk in HIV-infected populations in SSA.

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A Mini Review on New Pharmacological and Toxicological Considerations of Protease Inhibitors' Application in Cancer Prevention and Biological Research

Rahimi¹,

Hasanli²,

Jamalifar³

2011

Asian J. of Cell Biology

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Lipid Profile of Infected Patients Treated with Highly Active Antiretroviral Therapy in Cameroon

Cited by 4 publications

References 18 publications

Evaluation of HIV therapeutic agents on immunological, lipid and lipoprotein indices in Ghanaian HIV-1 infected patients

Evaluation of HIV therapeutic agents on immunological, lipid and lipoprotein indices in Ghanaian HIV-1 infected patients

Association of HIV and ART with cardiometabolic traits in sub-Saharan Africa: a systematic review and meta-analysis

A Mini Review on New Pharmacological and Toxicological Considerations of Protease Inhibitors' Application in Cancer Prevention and Biological Research

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