Lipid profile, ox‐LDL, and LCAT activity in patients with endometrial carcinoma and type 2 diabetes: The effect of concurrent disease based on a case–control study

Qahremani, Reihane; Rabizadeh, Soghra; Mirmiranpoor, Hossein; Yadegar, Amirhossein; Mohammadi, Fatemeh; Sahebi, Leyla; Heidari, Firouzeh; Esteghamati, Alireza; Nakhjavani, Manouchehr

doi:10.1002/hsr2.1537

Cited by 4 publications

(2 citation statements)

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“…ApoA1, as one of the main components of HDL-C, plays a vital role in the formation of most plasma-esterified cholesterol and helps to promote cholesterol efflux from tissues to the liver by being a cofactor for lecithin cholesterol acyl transferase (LCAT) [ 19 , 20 ]. ApoA1 modulates LDL-C function and its clearance by the liver.…”

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confidence: 99%

ApoA1/HDL-C ratio as a predictor for coronary artery disease in patients with type 2 diabetes: a matched case-control study

Ghaemi,

Rabizadeh,

Yadegar

et al. 2024

BMC Cardiovasc Disord

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Introduction This study investigated the possible relationship between the Apo lipoprotein A1 /high-density lipoprotein cholesterol (ApoA1/HDL-C) ratio and coronary artery disease (CAD) in patients with type 2 diabetes (T2D). Methods This was a matched case-control study of 482 patients with T2D in two groups of CAD and (n = 241) non-CAD (n = 241). The patients were classified into four quartiles according to the ApoA1/HDL-C ratio, and multivariate logistic regression analysis was performed to assess the relationship between ApoA1/HDL-C and CAD. ROC analysis was also conducted. Results This study showed that the ApoA1/HDL-C ratio has an independent association with CAD in individuals with T2D. The CAD group exhibited a significantly higher ApoA1/HDL-C ratio than those without CAD (p-value = 0.004). Moreover, the risk of CAD increased significantly across the ApoA1/HDL-C ratio quartiles, with the highest odds in the fourth quartile. The second quartile showed an odds ratio (OR) of 2.03 (p-value = 0.048) compared to the first. Moving to the third quartile, the OR increased to 2.23 (p-value = 0.023). The highest OR was noted in the fourth, reaching 3.41 (p-value = 0.001). Employing a cut-off value of 2.66 and an area under the curve (AUC) of 0.885, the ApoA1/HDL-C ratio predicts CAD among patients with T2D with a sensitivity of 75% and a specificity of 91% (p-value < 0.001). Conclusion The current study revealed an independent association between ApoA1/HDL-C ratio and CAD in patients with T2D. This ratio can be a promising tool for predicting CAD during the follow-up of patients with T2D, aiding in identifying those at higher risk for CAD.

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Section: Introductionmentioning

confidence: 99%

ApoA1/HDL-C ratio as a predictor for coronary artery disease in patients with type 2 diabetes: a matched case-control study

Ghaemi,

Rabizadeh,

Yadegar

et al. 2024

BMC Cardiovasc Disord

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“…So far, several pieces of research have been conducted on the effects of low HDL levels on cancer, cardiovascular events, and diabetes [ 16 , 23 – 25 ]. Recent studies have reported failure in reducing cardiovascular events, insulin resistance, diabetic retinopathy, cancer mortality rate, and unexpectedly increasing mortality in subjects with elevated HDL‐C levels [ 7 , 13 , 14 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Increased high-density lipoprotein cholesterol in patients with type 2 diabetes and its correlates: a cross-sectional, matched case–control survey

Heydarzadeh,

Mohammadi,

Yadegar

et al. 2024

Eur J Med Res

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Background So far, high-density lipoprotein cholesterol (HDL-C) levels and mortality were shown to have a U-shaped relationship. Additionally, high HDL-C levels increase the risk of developing a variety of diseases. However, a paucity of data exists regarding the characteristics of people with high HDL-C levels. The aim of this study was to assess the demographics and characteristics of patients with high HDL-C levels and compare their features with normal and low HDL-C groups. Methods As a cross-sectional, matched case–control study, a total of 510 patients with type 2 diabetes (T2D) were enrolled in the study and categorized into three matched groups according to their HDL-C concentrations. The studied groups were matched by their age and gender. Restricted cubic spline (RCS) curves were designed to evaluate the relationship between height, blood pressure, triglyceride, and vitamin D concentrations with the probability of having high HDL-C levels. Furthermore, violin plots were conducted to illustrate the distribution of continuous variables within each group. Results This study showed that having high HDL-C (more than 70 mg/dL) compared to having low HDL-C (less than 40 mg/dL in men and 50 mg/dL in women) was significantly associated with height (OR 0.918, 95% CI 0.866–0.974), systolic blood pressure (SBP) (0.941, 0.910–0.972), vitamin D (0.970, 0.941–0.999), and triglyceride (0.992, 0.987–0.998) serum concentrations. Further analysis investigated that having high HDL-C levels compared to desired HDL-C levels (40 ≤ HDL-C levels < 70 in men and 50 ≤ HDL-C levels < 70 in women) was inversely associated with having SPB values greater than 130 mmHg. Besides, sufficient vitamin D levels (above 20 ng/ml) could 0.349 times decrease the odds of having high HDL-C versus normal HDL-C levels. Conclusion Sufficient vitamin D levels, SPB values higher than 130 mmHg, as well as increased triglyceride levels, were inversely associated with having high HDL levels. However, higher height values were associated with a decreased likelihood of having high HDL.

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Relationship between advanced glycation end‐products and advanced oxidation protein products in patients with type 2 diabetes with and without albuminuria: A cross‐sectional survey

Larry,

Rabizadeh,

Mohammadi

et al. 2024

Health Science Reports

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Background and AimsLiterature suggests that oxidative stress plays a crucial role in the progression of diabetes. Since poor glycemic control enhances the formation of advanced glycation end‐products (AGEs) and advanced oxidation protein products (AOPP) in individuals with diabetes, exploring the association between glycation and oxidative states in diabetes could also shed light on potential consequences. This study evaluated the effects of albuminuria on AGEs and AOPP levels and measured their relationship in participants with type 2 diabetes (T2D) with or without albuminuria.MethodsA cross‐sectional, matched case‐control study was designed, including 38 T2D subjects with albuminuria and 38 matched T2D subjects with normoalbuminuria. Patients were matched by their body mass index (BMI), age, and duration of diabetes. The unadjusted and adjusted correlation between AGEs and AOPP in the studied groups were analyzed by multiple logistic regression. Using ggplot2, the ties between these two biochemical factors in cases and controls were plotted.ResultsThis study elucidated a significant association between AGEs and AOPP in participants with normoalbuminuria (r = 0.331, p‐value < 0.05), which continued to be significant after controlling for BMI, age, systolic blood pressure (SBP), and diastolic blood pressure (DBP) (r = 0.355, p‐value < 0.05). However, there was no significant association between AGEs and AOPP in those with albuminuria in the unadjusted model (r = 0.034, p‐value = 0.841) or after controlling for BMI, age, SBP, and DBP (r = 0.076, p‐value = 0.685).ConclusionOxidation and glycation molecular biomarkers were correlated in patients without albuminuria; however, this association was not observed in those with albuminuria.

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Lipid profile, ox‐LDL, and LCAT activity in patients with endometrial carcinoma and type 2 diabetes: The effect of concurrent disease based on a case–control study

Cited by 4 publications

References 55 publications

ApoA1/HDL-C ratio as a predictor for coronary artery disease in patients with type 2 diabetes: a matched case-control study

ApoA1/HDL-C ratio as a predictor for coronary artery disease in patients with type 2 diabetes: a matched case-control study

Increased high-density lipoprotein cholesterol in patients with type 2 diabetes and its correlates: a cross-sectional, matched case–control survey

Relationship between advanced glycation end‐products and advanced oxidation protein products in patients with type 2 diabetes with and without albuminuria: A cross‐sectional survey

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