Background/purpose: Hyperlipidemia is a kind of diseases with the characteristic of high level of blood lipids, it could directly result in several serious diseases including atherosclerosis and coronary heart disease to threat to human health. Therefore, to understand the epidemiological status and risk factors of hyperlipidemia is important for the prevention, diagnosis, and treatment of hyperlipidemia. Methods: The clinical data in Xinxiang Central Hospital from 2019-2021 were collected, and those data were classified and analyzed according to the basic information of investigation subjects and risk factors. Results: A total of 670 investigation subjects were collected in this investigation including 521 males and 149 females, accounting for 77.76% and 22.24% in the total investigation population, respectively; age range of investigation subjects was 20-97 year old; there were 390 people with a history of smoking and 346 people were never smoking, accounting for 58.21% and 51.64% in the total investigation population,respectively; in this investigation, the proportion of peasant farmers was the highest (353/670, 52.69%), followed by retire population (164/670, 24.48%); in terms of education level, the proportion of people graduating from middle school was the highest (338/670, 50.45%), followed by those graduating from primary school (249/670, 37.16%); the statistical results found that the incident of hyperlipidemia were correlated to gender (P<0.01), ethnicity (P<0.01), age (P<0.05), marital status (P<0.05), education level (P<0.001), hypertension (P<0.05) and diabetes mellitus (P<0.001), had no relation to occupation (P>0.05), cerebral hemorrhage, angina pectoris, ischemic stroke, gastrointestinal ulcers, coronary heart disease, chronic renal insufficiency, myocardial infarction, heart failure, peripheral artery disease, chronic obstructive pulmonary disease (P>0.05). Conclusion: The epidemiological status of hyperlipidemia in northern Henan Province had the specificity, the incident of hyperlipidemia was correlated to gender, ethnicity, age, marital status, education level, hypertension, and diabetes mellitus, those results may provide basis for the prevention and treatment for hyperlipidemia in northern Henan Province.