Lipid Profiles and Obesity as Potential Risk Factors of Sudden Sensorineural Hearing Loss

Lee, Joong Seob; Kim, Dong Hyun; Lee, Hyo‐Jeong; Kim, Hyung Jong; Koo, Ja Won; Choi, Hyo Geun; Park, Bumjung; Hong, Sung Kwang

doi:10.1371/journal.pone.0122496

Cited by 53 publications

(72 citation statements)

References 25 publications

(38 reference statements)

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“…In the present study we did not find higher levels of lipids in ISSHL patients. Similar results were reported by Chang et al [30], while other authors have reported a correlation between ISSHL and hyperlipidemia [31,32]. The role of hyperlipidemia needs therefore to be further investigated.…”

Section: Plos Onesupporting

confidence: 85%

Metabolic syndrome and idiopathic sudden sensori-neural hearing loss

et al. 2020

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The purpose of this study was to evaluate the association between the presence of Metabolic Syndrome (MetS) and idiopathic sudden sensorineural hearing loss (ISSHL) and the impact of MetS on recovery of patients with ISSHL. 39 Patients with ISSHL and 44 controls were enrolled in this study. Demographic, clinical characteristics and hearing recovery were evaluated. MetS was defined according to the diagnostic criteria of International Diabetes Federation (IDF) consensus definition. Patients affected by ISSHL presented a body mass index (BMI), waist circumference, waist hip ratio (WHR), fasting glucose and blood pressure significantly higher compared to controls. Considering patients with central obesity, 5 controls and 15 ISSHL patients met the criteria of MetS. According to Siegel criteria, a complete or partial recovery was observed in 60% of patients with MetS and in 91,66% of patients without MetS. MetS was associated with ISSHL and this association negatively influenced the hearing recovery of these patients.

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Section: Plos Onesupporting

confidence: 85%

Metabolic syndrome and idiopathic sudden sensori-neural hearing loss

et al. 2020

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“…27 Lipid metabolic disorders may contribute to cochlear ischemia due to increased blood viscosity and increased thickness of the endothelium of the terminal blood vessels through several mechanisms, including the formation of atheromatous plaques, endothelial dysfunction, and vascular inflamation. 8,[28][29][30] In this regard, a study 31 including 94 patients with SSNHL showed a significant negative correlation between hearing recovery and total cholesterol levels. Diabetes may also induce cochlear microangiopathy, resulting in SSNHL and reducing the rate of recovery from this condition.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of Oxidative-Stress Pathway and Recovery of Sudden Sensorineural Hearing Loss

Elias

Monsanto

Amaral

et al. 2020

Int Arch Otorhinolaryngol

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Introduction Although the pathogenesis of sudden sensorineural hearing loss (SSNHL) has been discussed in the literature, many unclear points remain. Several authors have hypothesized that oxidative stress plays a role in the pathogenesis of noise-related hearing loss, as well as in drug- and aging-related hearing loss. Reactive oxygen species (ROS) may contribute to the pathogenesis of SSNHL in a similar way as in cases of ototoxicity, noise-induced hearing loss and presbyacusis. Objective The aim of the present study was to find potential peripheral biomarkers to show the levels of oxidative stress in samples of peripheral blood collected from SSNHL patients with and withouth metabolic disease. Methods In total, 80 consecutive patients with SSNHL were evaluated in the otolaryngology emergency room and outpatient clinic of a tertiary hospital between May 2017 and May 2019. All patients underwent detailed anamnesis, physical examination, audiometry, magnetic resonance imaging (MRI) of the inner ears, and blood tests for serum lipids and plasma activity of thiobarbituric acid reactive species (TBARS). Results No significant effect of malondialdehyde (MDA) activity was observed regarding the hearing recovery of patients who developed SSNHL. Conclusion We did not observe a significant correlation between the concentration of TBARs in the peripheral blood or the presence of arterial hypertension and the severity of the initial hearing loss or the prognosis of hearing recovery in patients with SSNHL. The concentration of TBARs in the peripheral blood may not adequately represent the abnormalities that occur in the intracoclear environment.

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“…ILH may cause sudden hearing deterioration with vertigo in a patient on anticoagulant therapy or with a hematological disease; the prevalence has been reported as 0.3–6.25% in patients with SSNHL [ 7 , 22 , 23 ]. In our series of 200 3-T MRI scans, seven (3.6%) patients showed ILH on MRI, which was the second-most common finding after tumors invading the IAC (10 patients, 5.2%).…”

Section: Discussionmentioning

confidence: 99%

“…Although the exact etiology of SSNHL is still debated (such that it is classified as idiopathic), viral infections, immunological diseases, and impairment of the vascular microcirculation have been suggested as possible causes [ 2 , 4 – 6 ]. Recently, studies have shown that abnormal serum lipid levels [ 7 , 8 ] and thyroid dysfunction were also significantly associated with the occurrence and prognosis of SSNHL [ 9 ]. However, no laboratory test can accurately predict the prognosis of SSNHL and no treatment modality has been established based on medical evidence, despite biological plausibility.…”

Section: Introductionmentioning

confidence: 99%

Sudden sensorineural hearing loss associated with inner ear lesions detected by magnetic resonance imaging

et al. 2017

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Although recent advances in magnetic resonance imaging (MRI) techniques have contributed to the detection of tiny lesions in the internal auditory canal (IAC) that may be responsible for sudden sensorineural hearing loss (SSNHL), there have been relatively few studies on the clinical characteristics of intra-labyrinthine hemorrhage (ILH) and labyrinthitis versus those regarding IAC tumors. Our purpose was to investigate the frequency of those IAC lesions on MRI and their clinical characteristics. Initial MRIs of 200 patients with SSNHL (93 men, 107 women; mean age = 48.61 years, range: 18–84 years), as well as detailed clinical histories, audiological examinations, and thyroid function, lipid battery, and serological tests (for viral agents and autoimmune disease), were performed. All patients were hospitalized at the time of diagnosis of SSNHL and were administered the same treatment protocol. Patients were divided into idiopathic and secondary groups according to their MRI results. After discharge, they underwent follow-up audiometry and clinical examination at predetermined intervals (2 weeks, 1, 2, 4, and 6 months, and 1 and 2 years). Propensity score-matching and receiver operating characteristics curves of the initial parameters were used for estimating clinical characteristics. Of the 200 patients, 25 (12.55%) who had abnormal findings suggesting inner ear lesions on MRI were assigned to the secondary SSNHL group; within this group, 10 patients (10/200, 5%) had a tumor invading the IAC, 7 (7/200, 3.5%) had ILH, 6 (6/200, 3%) had labyrinthitis, and 2 (1%) had a structural deformity of the IAC. The secondary group showed significantly poor recovery of hearing function compared with that in the idiopathic group. Patients with ILH or labyrinthitis showed prognoses that were equally poor as those of patients with tumors in the secondary group. Additionally, patients with such lesions showed significant canal paresis on the lesion side at an early stage and a high prevalence of benign paroxysmal positional vertigo (BPPV). In conclusion, the prevalence of non-tumorous lesions on MRI represents common findings and showed a poorer treatment response than that of vestibular Schwannoma in patients with SSNHL. Abnormal canal paresis (cut-off value of 35% on the lesioned side, sensitivity 65.2% and specificity 67%), spontaneous nystagmus directed to the contralesional side, and positional vertigo would be the clinical presentation of SSNHL with IAC lesions, in which the presence of acute prolonged vertigo or positional vertigo compatible with BPPV suggests the possibility of a non-tumorous lesion, such as ILH or a labyrinthitis rather than an IAC tumor.

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Lipid Profiles and Obesity as Potential Risk Factors of Sudden Sensorineural Hearing Loss

Cited by 53 publications

References 25 publications

Metabolic syndrome and idiopathic sudden sensori-neural hearing loss

Metabolic syndrome and idiopathic sudden sensori-neural hearing loss

Evaluation of Oxidative-Stress Pathway and Recovery of Sudden Sensorineural Hearing Loss

Sudden sensorineural hearing loss associated with inner ear lesions detected by magnetic resonance imaging

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