Lipid-Protein Interactions in the Structure of Biological Membranes

Lenaz, Giorgio

doi:10.1007/978-1-4684-2016-6_28

Cited by 10 publications

(6 citation statements)

References 344 publications

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“…Since the disulphide moiety can play a large part in maintaining the threedimensional structure of proteins, the increase in the -SH content of the rheumatoid synoviocytes implies a loss of protein stability in these cells. As cellular membranes can contain up to 60% protein (Lenaz, 1974), alterations in the proportion of the sulphur-containing amino acids in the reduced form may play a part in determining membrane stability, and therefore membrane function. This premise is supported by the finding of significantly increased lysosomal permeability in human rheumatoid synoviocytes (Chayen et al, 1971a).…”

Section: Discussionmentioning

confidence: 99%

Altered phospholipids in human rheumatoid synoviocytes.

Henderson¹,

Bitensky²,

Chayen³

1978

Annals of the Rheumatic Diseases

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SUMMARY A specific cytochemical reaction for freely available phospholipids has shown a raised concentration of such phospholipids in the lining cells of human synovial membranes removed from rheumatoid joints. Quantitative measurement, by microdensitometry, of the amount of reactionproduct per cell showed that the rheumatoid synoviocytes contained almost three times the amount of free phospholipids present in the equivalent nonrheumatoid cells; statistically the difference was highly significant. Evidence from studies in which the bound phospholipids were 'unmasked' by methanol-chloroform confirmed the view that the increased content of freely available phospholipids was related to altered lipid-protein binding rather than to an increase in total phospholipids.

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Section: Discussionmentioning

confidence: 99%

Altered phospholipids in human rheumatoid synoviocytes.

Henderson¹,

Bitensky²,

Chayen³

1978

Annals of the Rheumatic Diseases

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“…[2] ). Since, apparently, the biological function of an integral membrane protein is exerted by a combined action of the protein and neighbouring lipid and protein molecules (e.g., [3][4][5] ), efforts aimed at a better understanding of the mechanism of anion transport may benefit from studies on the interactions of the band 3-protein with other components of the erythrocyte membrane. Moreover, such studies are of obvious interest for the problem of erythrocyte membrane structure.…”

Section: Introductionmentioning

confidence: 99%

Band 3‐protein from human erythrocyte membranes strongly interacts with cholesterol

Klappauf¹,

Schubert²

1977

FEBS Letters

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“…or phase separations, are usually gradual with continuous dQ/dt, as measured by scanning calorimetry. They are considered to involve lipids and water in so-called "thermotropic mesomorphism" (3,12). The phase changes, for illustration, can be in the degree of lipid-H20 organization as from partial order (gel) toward disorder, or crystalline (highly organized) to a liquid crystalline (mesomorphic) state as an extreme.…”

mentioning

confidence: 99%

Variation in Germination and Amino Acid Leakage of Seeds with Temperature Related to Membrane Phase Change

Hendricks

Taylorson²

1976

Plant Physiol.

103

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Leakages of amino acids and/or fluorescent material as functions of temperature between 15 and 40 C are reported for imbibed seeds of Avenafatua L., Lactuca sativa L., Barbarea vulgaris R. Br., Amaranthus albus L., Abutilon theophrasti Medic., Lychnis alba Mill., Daucus carota L., Setaria faberi Herrm., Setaria viridis (L.) Beauv., and Datura stramonium L. The leakage indicates prominent increase in permeability of the plasmalemma in the 30 to 35 C range for 8 of the 10 kinds of seeds studied. Germination of the seeds at constant temperatures or with daily shifts in temperature is related to the membrane transition temperature for permeation by amino acids. Seeds of A. albus and A. theophrasti, which did not show membrane changes in the 25 to 40 C range, germinated best at 35 to 40 C; the other seeds germinated best below 30 C. Seeds of B. vulgaris showed rapid permeation of limiting membranes upon initial wetting with water, which was indicative of membrane disorder when dry. Leakage under anaerobiosis was observed for S. faberi seeds.Dependence of seed germination on the temperature regime has been widely examined. While Seed germinations were determined on multiple lots of 100 seeds, each imbibed in water on saturated filter paper in Petri dishes. The dishes were placed in darkness in water-saturated chambers at various constant temperatures. Other lots, after being held for 16 hr at 20 C, were shifted each day for 8 hr to 30 or 35 C. Tests were of sufficient duration to express most of the germination response. Seeds with visibly emergent radicles were scored as germinated.Leakage from Seeds. Leakage to water of amino acids and/or fluorescent constituents was measured for initially dry seeds, or seeds that had imbibed water in darkness for 16 to 20 hr at 15 C, followed by thorough washing with water at 15 C under very low intensity green light. The leakages were measured for lots in water (0.07-0.1 g air-dry weight/ml) for various times at temperatures constant to I C. Losses were measured for 4 hr on replicates of 0.2 to 0.5 g in darkness for all seeds. Measurements were made for D. stramonium, B. vulgaris, and S. faberi seeds both in water and in 10 mm CaSO, in darkness.

show abstract

Lipid-Protein Interactions in the Structure of Biological Membranes

Cited by 10 publications

References 344 publications

Altered phospholipids in human rheumatoid synoviocytes.

Altered phospholipids in human rheumatoid synoviocytes.

Band 3‐protein from human erythrocyte membranes strongly interacts with cholesterol

Variation in Germination and Amino Acid Leakage of Seeds with Temperature Related to Membrane Phase Change

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