Lipid raft localization of epidermal growth factor receptor alters matrix metalloproteinase-1 expression in SiHa cells via the MAPK/ERK signaling pathway

Zhang, Zongfeng; Wang, Lina; Du, Juan; Li, Yuanbo; Yang, Huilun; Li, Chenxi; Li, Hui; Hu, Haiyang

doi:10.3892/ol.2016.5307

Cited by 34 publications

(32 citation statements)

References 47 publications

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“…1) [10]. Currently, these domains are considered a predominant feature of the plasma membrane and appear to mediate critical signaling processes [11, 12], including the stabilization of β-catenin via stimulation of Wnt pathway-associated receptors [13–15], epidermal growth factor receptor (EGFR) signaling [16–18], and the activation of MAPK/ERK pathway components through membrane-bound Ras proteins [19–21], to name a few examples (Table 1). Interestingly, dysregulation of plasma membrane homeostasis, in part, due to the products of gene mutations as well as changes in protein and lipid localization, alters the degree of clustering and other biochemical and biophysical trademarks, thereby providing a suitable environment for the initiation of cancer-related signaling processes [22–24].…”

Section: Introductionmentioning

confidence: 99%

Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents

Erazo-Oliveras

Fuentes

Wright

et al. 2018

Cancer Metastasis Rev

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The cell plasma membrane serves as a nexus integrating extra- and intracellular components, which together enable many of the fundamental cellular signaling processes that sustain life. In order to perform this key function, plasma membrane components assemble into well-defined domains exhibiting distinct biochemical and biophysical properties that modulate various signaling events. Dysregulation of these highly dynamic membrane domains can promote oncogenic signaling. Recently, it has been demonstrated that select membrane-targeted dietary bioactives (MTDBs) have the ability to remodel plasma membrane domains and subsequently reduce cancer risk. In this review, we focus on the importance of plasma membrane domain structural and signaling functionalities as well as how loss of membrane homeostasis can drive aberrant signaling. Additionally, we discuss the intricacies associated with the investigation of these membrane domain features and their associations with cancer biology. Lastly, we describe the current literature focusing on MTDBs, including mechanisms of chemoprevention and therapeutics in order to establish a functional link between these membrane-altering biomolecules, tuning of plasma membrane hierarchal organization, and their implications in cancer prevention.

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Section: Introductionmentioning

confidence: 99%

Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents

Erazo-Oliveras

Fuentes

Wright

et al. 2018

Cancer Metastasis Rev

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“…EA also binds to GPR40 and 120, inducing the transactivation of EGFR via c-src (5). Lipid rafts represent a special localization of epidermal growth factor receptors (EGFRs), altering its signaling pathways (10) and transactivation (11). Rao et al have reported that EA can affect Fas/FasL-induced apoptosis via lipid rafts (12).…”

Section: Introductionmentioning

confidence: 99%

Pro‑metastatic signaling of the trans fatty acid elaidic acid is associated with lipid rafts

et al. 2018

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Abstract. Trans fatty acids (TFAs) are risk factors for cardiovascular disorders, and the cancer-promoting effects of TFAs have been previously reported. The present study examined the effects and signaling of elaidic acid (EA), a TFA, in colorectal cancer (CRC) cells. Oral intake of EA was found to increase metastasis of HT29 human CRC cells. Results indicated that, in the plasma membrane, EA was integrated into cholesterol rafts, which contain epidermal growth factor receptors (EGFR). EA increased nanog and c-myc, and decreased PGC-1A through lipid raft-associated EGFR signaling in HT29 cells. Depletion of cholesterol by methyl-β-cyclodextrin treatment abrogated the EA-induced stemness and oxidative phosphorylation. Simvastatin treatment also abrogated EA-enhanced tumor growth. These results indicate that EA enhances the stemness by activating EGFR in lipid rafts.

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“…Overexpression of MMP1 is strongly associated with unfavorable prognosis in multiple malignancies including breast cancer, esophageal squamous cell carcinoma, and ovarian cancer [21][22][23]. MMP1 has also previously been proposed as a risk factor in CC [24,25]. SPP1 participates in the regulation of tumor-associated angiogenesis and in ammation [26].…”

Section: Discussionmentioning

confidence: 99%

A novel four-gene prognostic signature as a risk biomarker in cervical cancer

Wang

Zheng

Han

et al. 2020

Preprint

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Background: Cervical cancer (CC) is a major malignancy affecting women worldwide, with limited treatment options for patients with advanced disease. The aim of this study was to identify novel prognostic biomarkers for CC by a bioinformatics-based analysis using the Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA)-CC cohort. Methods: RNA-Seq data from four GEO datasets (GSE5787, GSE6791, GSE26511, and GSE63514) were used to identify differentially expressed genes (DEGs) between CC and normal cervical tissues. Functional and enrichment analyses of the DEGs were performed using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database and the Database for Annotation, Visualization and Integrated Discovery (DAVID). The Oncomine database, Cytoscape software, and Kaplan–Meier survival analysis were used for in-depth screening for hub DEGs. Cox regression was then used to develop prognostic signature, which was in turn used to create a nomogram. Results: A total of 207 DEGs were identified in the tissue samples, eight of which were prognostically significant in terms of overall survival (OS). Thereafter, a novel four-gene signature consisting of DSG2, MMP1, SPP1, and MCM2 was developed and validated using stepwise Cox analysis. The area under the receiver operating characteristic (ROC) curve (AUC) values of 0.785, 0.609, and 0.686 in the training, verification, and combination groups, respectively. Moreover, the nomogram analysis showed that a combination of this four-gene signature plus lymph node metastasis (LNM) status effectively predicted the 1- and 3-year OS probabilities of CC patients with accuracies of 69.01% and 83.93%, respectively. Conclusions: We developed a four-gene signature that can accurately predict the prognosis, in terms of OS, of CC patients, and could be a valuable tool for designing treatment strategies.

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Lipid raft localization of epidermal growth factor receptor alters matrix metalloproteinase-1 expression in SiHa cells via the MAPK/ERK signaling pathway

Cited by 34 publications

References 47 publications

Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents

Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents

Pro‑metastatic signaling of the trans fatty acid elaidic acid is associated with lipid rafts

A novel four-gene prognostic signature as a risk biomarker in cervical cancer

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