Lipid ratio as a suitable tool to identify individuals with MetS risk: A case- control study

Abbasian, Maryam; Delvarianzadeh, Mehri; Ebrahimi, Hossein; Khosravi, Farideh

doi:10.1016/j.dsx.2016.08.011

Cited by 16 publications

(13 citation statements)

References 21 publications

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“…The LDL-C/ HDL-C ratio is regarded as a marker for carotid intima-media thickness (CIMT) progression [12]. In addition, several lipid ratios (apo B/apo A-I, TC/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C) have shown clinically important correlations with coronary artery lesions, insulin resistance, and metabolic syndrome [13][14][15]. Moreover, higher LDL-C and lower HDL-C were associated with the presence of ICAS in a population-based study [16].…”

Section: Introductionmentioning

confidence: 99%

Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

Yang

Shen

et al. 2020

Lipids Health Dis

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Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population. Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL

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Section: Introductionmentioning

confidence: 99%

Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

Yang

Shen

et al. 2020

Lipids Health Dis

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“…They are among the inflammatory markers that are considered as reliable prognostic indicators for diabetes complications. 12,13 In addition, atherogenic index of plasma (AIP; log TG/HDL-C) has lately been considered as a surrogate estimate of the atherogenicity dyslipidemia among T2DM patients. 14,15 Also, adiposity markers such as conicity index (CI), body adiposity index (BAI) and waist-height ratio (WHtR) are investigated for the estimation of the risk of coronary heart diseases.…”

Section: Introductionmentioning

confidence: 99%

Glycated LDL-C and glycated HDL-C in association with adiposity, blood and atherogenicity indices in metabolic syndrome patients with and without prediabetes

Saudi

Kasabri

Naffa

et al. 2018

Therapeutic Advances in Endocrinology

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Background: The aim of the study was to compare and correlate glycated high-density lipoprotein (GHDL-C) and glycated low-density lipoprotein (GLDL-C) plasma levels with adiposity indices [weight/hip ratio (WHR) and body adiposity index (BAI)], lipid ratios and hematological indices [platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR)]. Methods: This was a cross-sectional study of 30 nondiabetic metabolic syndrome (MetS) patients, 30 prediabetic or type 2 diabetes mellitus (T2DM) patients and 30 normoglycemic controls. Results: Remarkably both GHDL-C and GLDL-C levels lacked any intergroup statistically significant discrepancy in either MetS or MetS-pre/T2DM versus control (p > 0.05). Unlike GLDL-C/LDL-C ratios for either MetS groups; there were highly significant intergroup differences in the means of GHDL-C/HDL-C ratios when comparing both nondiabetic MetS and MetS-pre/T2DM groups versus controls (p = 0.001). In MetS patients; GHDL-C and GLDL-C proportionally correlated with WHR (p < 0.05). Also, MetS GHDL-C correlated inversely with MLR and monocytes (p < 0.05). In MetS-pre/T2DM; GLDL-C directly correlated with BAI, platelet count and PLR (p < 0.05). Conclusion: GLDL-C and GHDL-C are dysfunctional glucolipotoxicity lipoproteins and may present putatively surrogate biomarkers for prediction/prevention of metabolic disturbances.

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“…The LDL-C/HDL-C ratio is regarded as a marker for carotid intima-media thickness (CIMT) progression [11]. In addition, some lipid ratios (apo B/apo A-I, TC/HDL-C, LDL-C/HDL-C, and non-HDL-C/HDL-C) have shown clinically important correlations with coronary artery lesions, insulin resistance, and the metabolic syndrome [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

Yang

Shen

et al. 2020

Preprint

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Abstract Background: We wished to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population. Methods: We included 658 consecutive patients with ischemic stroke in our cross-sectional study. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated. Results : Ratios of TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I were associated significantly with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Analyses of receiver operating characteristic (ROC) curves revealed the apo B/apo A-I ratio have the highest area under the ROC curve (AUC) value for a lipid level alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for a lipid level alone for identifying ICAS. Conclusion : The ratios of TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C and apo B/apo A-I were related significantly to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be better discriminator for identifying ICAS risk.

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Lipid ratio as a suitable tool to identify individuals with MetS risk: A case- control study

Cited by 16 publications

References 21 publications

Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

Glycated LDL-C and glycated HDL-C in association with adiposity, blood and atherogenicity indices in metabolic syndrome patients with and without prediabetes

Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

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