Lipid Replacement and Antioxidant Nutritional Therapy for Restoring Mitochondrial Function and Reducing Fatigue in Chronic Fatigue Syndrome and Other Fatiguing Illnesses

Abstract

Evidence in the literature indicates that diminished mitochondrial function through loss of efficiency in the electron transport chain caused by oxidation occurs during aging and in fatiguing illnesses. Lipid Replacement Therapy (LRT) administered as a nutritional supplement with antioxidants can prevent oxidative membrane damage, and LRT can be used to restore mitochondrial and other cellular membrane functions via delivery of undamaged replacement lipids to cellular organelles. Recent clinical trials using patients with chronic fatigue have shown the benefit of LRT plus antioxidants in restoring mitochondrial electron transport function and reducing moderate to severe chronic fatigue. These studies indicate the benefits of LRT plus antioxidants in reducing fatigue and preventing loss of mitochondrial function, most likely by protecting mitochondrial and other cellular membranes from oxidative and other damage and removing damaged lipids by lipid replacement. In one clinical study we determined if mitochondrial function is reduced in subjects with mild to severe chronic fatigue, and if this can be reversed Journal of Chronic Fatigue Syndrome Downloaded from informahealthcare.com by Nyu Medical Center on 07/10/15 For personal use only.with NTFactor ® , a nutritional supplement that replaces damaged cellular lipids. With the use of the Piper Fatigue Scale, there was a significant time-dependent reduction in overall fatigue in moderately or severely fatigued subjects while on the dietary supplement for 4-8 weeks. Analysis of mitochrondrial function indicated that four and eight weeks of the dietary supplement in moderately or severely fatigued subjects significantly increased mitochondrial function. Similarly, chronic fatigue syndrome patients administered antioxidants plus LRT also show reductions in fatigue. The results indicate that LRT plus antioxidants can significantly reduce moderate to severe chronic fatigue and restore mitochondrial function. Dietary use of unoxidized membrane lipids plus antioxidants is recommended for patients with moderate to severe chronic fatigue.

Lipid Replacement Therapy with a Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Fatigue in Intractable Chronic Fatiguing Illnesses and Chronic Lyme Disease Patients

“…Those who described a condition consistent with the definition of moderate to severe fatigue as defined in the PFS [20][21][22] were directed to take an online survey after they completed an Informed Consent document. A follow-up was conducted to determine any physician's diagnosis as well as complete description of their condition and laboratory tests that were used to confirm their diagnosis ( Table 2).…”

“…LRT can result in the cellular delivery of unoxidized, undamaged membrane glycophospholipids in order to replace damaged lipids and restore function to oxidized cellular membranes. Combined with antioxidant supplements, LTR has proven to be an effective method to prevent ROS/ RNS-associated changes in cellular activities and functions and for use in the treatment of various clinical conditions [6,12,20].…”

Neurodegenerative and Fatiguing Illnesses, Infections and Mitochondrial Dysfunction: Use of Natural Supplements to Improve Mitochondrial Function.

“…Similar findings on fatigue reduction were observed in chronic fatigue syndrome and fibromyalgia syndrome patients given oral membrane phospholipids (NT Factor) [293]. Using a new formulation of NT Factor plus vitamins, minerals and other supplements in patients with moderate chronic fatigue resulted in a 36.8% reduction in fatigue within one week [295] (Table 3).…”

“…The use of oral membrane phospholipids plus antioxidants in doses ranging from 500-2,000 mg per day has been effective in the treatment of various clinical conditions, such as CFS and other fatiguing illnesses (Table 2) [6,7,136,212,292,293]. LRT results in the actual replacement of damaged membrane phospholipids with undamaged (unoxidized) lipids to ensure proper function of cellular and especially mitochondrial membranes.…”

Nutritional Supplements for Cancer-Associated

“…Lipid Replacement Therapy plus antioxidants can reverse ROS/RNS damage and increase mitochondrial function in certain fatiguing disorders, such as chronic fatigue, chronic fatigue syndrome and fibromyalgia syndrome. Lipid Replacement Therapy has been found to be effective in preventing ROS/RNS-associated changes and reversing mitochondrial damage and loss of function (reviewed in Nicolson, 2010;Nicolson & Ellithrope, 2006). Lipid Replacement Therapy with unoxidized lipid and antioxidant supplements has been effective in replacement of damaged cellular and mitochondrial membrane phospholipids and other lipids that are essential structural and functional components of all biological membranes (reviewed in Nicolson, 2010;Nicolson & Ellithrope, 2003).…”