Lipid Serum Profile in Patients with Viral Liver Cirrhosis

Abstract

Objective: Our main aim was to investigate the serum lipid levels in a series of patients with liver cirrhosis of viral origin. Subjects and Methods: The study comprised 90 patients, 60 with viral liver cirrhosis, equally divided between hepatitis virus C (HCV) and B (HBV) etiologies, and 30 control patients with no known liver pathology. Patients were investigated during a 5-year period in the 1st Medical Clinic of the Emergency County Hospital of Craiova, Romania. The following series of serum lipid parameters were recorded: lipemia, total cholesterol and cholesteryl ester, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol and triglyceride (TG) values. Statistical analysis of these parameters was performed using the ANOVA test followed by Tukey multiple comparison teststo compare replicate means; p < 0.05 was considered statistically significant. Results: We observed significantly lower values for serum lipids (543.5 and 549.37 mg/dl in the HBV and HCV cirrhosis subgroups, compared with 649.9 mg/dl in controls), total cholesterol (143.6 and 147.9 vs. 198.0 mg/dl, respectively), cholesteryl esters (83.6 and 80, compared to 147.9 mg/dl, respectively), LDL cholesterol (91.6 and 88.5 vs. 132.4 mg/dl) in both cirrhosis groups when compared with controls (p < 0.001), as well as HDL cholesterol (32.1 and 36.9 vs. 47.3 mg/dl, p < 0.05). However, TG and VLDL cholesterol values of controls and cirrhosis groups were similar (p > 0.05). We did not register any differences between the two cirrhosis groups (p > 0.05). Conclusion: Our data showed that both HCV and HBV cirrhosis severely impaired liver lipid metabolism. Late stages of the disease resulted in a pseudonormalization of VLDL cholesterol and TG values.

LIPID PROFILE OF CIRRHOTIC PATIENTS AND ITS ASSOCIATION WITH PROGNOSTIC SCORES: a cross-sectional study

“…Hypocholesterolemia and hypotriglyceridemia are both significantly associated and correlated with the Child-Pugh and MELD prognostic criteria. These findings were consistent with previous studies that showed changes in lipid metabolism in advanced stages of cirrhosis (1,13,21) .…”

Relationship analysis between gene expression profiles and rat liver cirrhosis occurrence

“…Previous studies proved that lipid metabolism was severely impaired in liver cirrhosis originating from hepatitis C and B viruses (Vere et al, 2012), implying that the process of lipid metabolism was attenuated during liver cirrhosis. Surprisingly, fatty acid metabolism was activated at 3 weeks and slightly inhibited at 6 weeks.…”

Systemic Hepatic-Damage Index for Predicting the Prognosis of Hepatocellular Carcinoma after Curative Resection

“…Moreover, low TC level was reported to be in close association with severe liver fibrosis in these patients. It is implied that liver functional reserve became poorer with the decrease of TC (Vere et al, 2012; Wang et al, 2014). Several studies have shown low serum TC level and low serum HDL level were associated with worse disease-free survival and overall survival in HCC patients undergoing surgical hepatectomy, breast cancer patients, colorectal cancer patients receiving adjuvant chemotherapy, and non-small-cell lung patients with EGFR mutations (Lee et al, 2016; Li et al, 2016; Wang et al, 2016; Zhang et al, 2017).…”