Lipid spectrum of erythrocyte membranes in cancer patients

Новицкий, В. В.; Stepovaya, E. A.; Bazhenova, Natalia; Goldberg, V. Е.; Kolosova, M. V.; Сапрыкина, Э. В.; Gubert, E A; Sokolova, I. B.; Koreshkova, K. G.; Bulavina, Ya. V.

doi:10.1007/bf02446921

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…As regards the lipids, various classes (glycerolipids, sphingolipids, sterols) of these compounds were identified in human membranes and their concentration both in healthy erythrocytes and in pathologically disturbed cells were precisely estimated [1,3,4]. Extremely important finding relating to composition of membranes concerns asymmetrical distribution of lipids between inner and outer layers.…”

Section: Introductionmentioning

confidence: 99%

The influence of cholesterol on multicomponent Langmuir monolayers imitating outer and inner leaflet of human erythrocyte membrane

Wydro¹

2013

Colloids and Surfaces B: Biointerfaces

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Section: Introductionmentioning

confidence: 99%

The influence of cholesterol on multicomponent Langmuir monolayers imitating outer and inner leaflet of human erythrocyte membrane

Wydro¹

2013

Colloids and Surfaces B: Biointerfaces

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“…In formulating new generalizations, we have seen that they are easily integrated into the existing knowledge system [100,117,[120][121][122][123]137]. This allowed us to reach the theory of a typical pathological process [99], which has been actively developed in recent decades [138][139][140][141][142][143]. It turned out that the concepts of cycles • NO and [92,100,116,117,122,130,144,145], the principles of cyclicity and the holographic principle [121,137] complement well the theory of a typical pathological process [99,[137][138][139][140][141][142][143].…”

Section: Problems and Prospectsmentioning

confidence: 99%

“…This allowed us to reach the theory of a typical pathological process [99], which has been actively developed in recent decades [138][139][140][141][142][143]. It turned out that the concepts of cycles • NO and [92,100,116,117,122,130,144,145], the principles of cyclicity and the holographic principle [121,137] complement well the theory of a typical pathological process [99,[137][138][139][140][141][142][143]. We consider the following conclusions to be the most significant generalizations: (1) pathology begins with a violation of normal regulatory cycles that maintain basic biochemical and physiological parameters within normal limits; (2) cycles of nitric oxide and superoxide anion radical with heme-containing proteins and antioxidant protection systems do not allow direct interaction of • NO and • O 2 and the formation of nitrogen dioxide ( • NO 2 ) and • OH radicals capable of destroying almost all components of cells and subcellular structures; (3) violation of the above cycles of • NO and • O 2 lead to a transition from the norm to the development of various pathological processes.…”

Section: Problems and Prospectsmentioning

confidence: 99%

Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain–Intestine Axis

Реутов

Sorokina

2022

BIOPHYSICS

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The brain and gastrointestinal tract are the most important organs responsible for detecting, transmitting, integrating, and responding to signals coming from the internal and external environment. A bidirectional system of neurohumoral communication (the "intestine-brain" axis) combines the activity of the intestine and brain (or brain and intestine) of a person. It affects human development and behavior. This paper analyzes the literature data on the existence of a relationship between the central and enteral nervous systems. Based on data on the number of neurons in the enteral nervous system (approximately 250 million nerve cells), the concept of a "second brain" in the intestine has been proposed in foreign literature, which, by its influence on the brain, can have a more powerful influence than the spinal cord (approximately 10 million neurons) with its autonomic nervous system. However, it turned out that Russian scientists, academicians of the Academy of Sciences of the Soviet Union I.P. Pavlov, K.M. Bykov, and A.M. Ugolev, analyzed cortical-visceral relationships in the 20th century and wrote about the existence of a connection between the central and enteral nervous systems. One of the urgent problems of modern physiology, pathophysiology, biophysics, biochemistry, and medicine is to clarify the causal relationship between the central and enteral nervous systems, as well as between neurological, mental, and gastrointestinal diseases in order to combine the efforts of specialists of various medical and biological profiles to solve urgent medical problems.

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Externalization of phosphatidylserine from inner to outer layer may alter the effect of plant sterols on human erythrocyte membrane — The Langmuir monolayer studies

Hąc-Wydro

Dynarowicz-Łątka

2012

Biochimica et Biophysica Acta (BBA) - Biomembranes

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One of the factors, which can strongly modify the cell membrane composition, is disordering in membrane asymmetry, resulting from redistribution of lipids from inner to outer layer. Such a disturbance may affect the behavior of various biologically active compounds incorporating into membranes. In this contribution, the relationship between the amounts of phosphatidylserine (PS) in the model outer layer of human erythrocyte (RBC) membrane and the effect induced by a plant sterol (β-sitosterol) was verified. The experiments were performed on multicomponent Langmuir films imitating red blood cell (RBC) membrane, differing in the contents of PS (0%; 5% and 10%) into which the plant sterol was incorporated in various concentrations. The analysis of experimental results (surface pressure-area isotherms complemented with Brewster Angle Microscopy (BAM) proved that the presence of phosphatidylserine molecules, depending on their contents in the mixed monolayer mimicking RBC membrane, changes its properties and exerts influence on the effect of plant sterol on the model system. The addition of phytosterol into the monolayer that lacks or contains only 5% of PS was found to be of rather weak effect on the properties of the system. However, in the case of the model membrane containing the increased amount (10%) of PS, the incorporation of plant sterol strongly affects the interactions between molecules and caused thermodynamic destabilization of the monolayer imitating RBC membrane. These results allow one to suggest that externalization of phosphatidyserine to the outer membrane leaflet may differentiate the effect of plant sterols on cell membranes of various origins.

show abstract

Lipid spectrum of erythrocyte membranes in cancer patients

Cited by 5 publications

References 5 publications

The influence of cholesterol on multicomponent Langmuir monolayers imitating outer and inner leaflet of human erythrocyte membrane

The influence of cholesterol on multicomponent Langmuir monolayers imitating outer and inner leaflet of human erythrocyte membrane

Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain–Intestine Axis

Externalization of phosphatidylserine from inner to outer layer may alter the effect of plant sterols on human erythrocyte membrane — The Langmuir monolayer studies

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