Lipid synthesis by red blood cell preparations in Wolman's disease (a familial lipidosis)

Wolman's disease. A rare lipidosis with adrenal calcification.

“…The mechanism of the enhanced cholesterol storage is not known; presumably it is either due to a defect in cholesterol disposal mechanisms or to a defect in the control of cholesterol biosynthesis. Studies by Sloviter, Janic and Naiman (1968) have demonstrated enhanced incorporation of radioactive glycerol and mevalonic acid into the triglyceride and cholesterol ester fractions of red cell membranes, and suggest an increased rate of synthesis.…”