Lipid transfer protein sensitization: reactivity profiles and clinical risk assessment in an Italian cohort

Scala, Enrico; Till, Stephen J.; Asero, Riccardo; Abeni, Damiano; Guerra, Emanuele; Pirrotta, L.; Paganelli, Roberto; Pomponi, Debora; Giani, Mauro; Pità, Ornella De; Cecchi, Lorenzo

doi:10.1111/all.12635

Cited by 106 publications

(153 citation statements)

References 46 publications

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“…Scala et al [26] investigated the prevalence of nsLTP sensitization in a large Italian cohort and found that there was a correlation between sensitization to pollen and plant food nsLTPs, and mugwort pollen extracts could inhibit 50-100% IgE binding to food nsLTPs. All the subjects included in this study were from northern China, where mugwort produces the most common allergenic pollens that lead to seasonal rhinitis and/or asthma in late summer and autumn [27].…”

Section: Discussionmentioning

confidence: 99%

Component-Resolved Diagnosis of Peanut Allergy and Its Possible Origins of Sensitization in China

Nie

et al. 2016

Int Arch Allergy Immunol

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Background: Clinical and immunological characteristics of food allergies vary depending on geographic regions. Little is known about peanut allergy in China. The aim of this study was to investigate the peanut sensitization profile in China. Methods: Thirty-eight participants with immunoglobulin E (IgE)-positive responses to peanuts (peanut-sensitized) were included in our study, and clinical characteristics were evaluated. Total and specific IgE reactivity against peanuts, other plant-derived foods, pollens, and related allergen components were determined. Results: Eighteen patients were symptomatic when exposed to peanuts. The majority of them presented with systemic reactions. More than half of the peanut-sensitized subjects also suffered from mugwort pollinosis and peach allergy. In patients with both peanut and peach allergies, reactions to peanuts were the same as or severer than those to peaches. Positivity rates of IgE response to rAra h 1-3, 8, and 9 in the peanut allergy group were 5.6, 11.1, 5.6, 22.2, and 83.3%, respectively. 66.7% (12/18) of the peanut-allergic patients were monosensitized to rAra h 9. Anti-nArt v 3 [mugwort nonspecific lipid transfer protein (nsLTP)] IgE positivity in the peanut allergy group was significantly higher than that in the asymptomatic peanut-sensitized group. In Ara h 9 (peanut nsLTP)-sensitized patients with mugwort pollinosis, anti-nArt v 3 IgE levels were remarkably higher than anti-rAra h 9 (peanut nsLTP) IgE levels as well as anti-Pru p 3 (peach nsLTP) IgE levels. Conclusions: Ara h 9 was the major allergen of peanut, and Ara h 9 monosensitization was the most common peanut sensitization pattern in our population. Furthermore, there was a strong correlation between peanut sensitization and mugwort pollinosis, as well as peach allergy, in our country.

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Section: Discussionmentioning

confidence: 99%

Component-Resolved Diagnosis of Peanut Allergy and Its Possible Origins of Sensitization in China

Nie

et al. 2016

Int Arch Allergy Immunol

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“…It is also true that patients with LTP syndrome show a complex clinical pattern and multiple sensitizations to plant foods and pollens that complicate management [9][10]. The main offending foods reported by patients, and confirmed by sensitization in skin prick tests (SPTs), are peach (75.6%), lettuce (48.9%), walnut (46.7%), and hazelnut (33.3%) [7].…”

Section: Introductionmentioning

confidence: 99%

Lettuce Allergy Is a Lipid Transfer Syndrome-Related Food Allergy With a High Risk of Severe Reactions

Muñoz-García¹,

Luengo²,

Moreno-Pérez³

et al. 2017

J Investig Allergol Clin Immunol

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Background and Objectives: Lipid transfer protein (LTP) sensitization is the most common cause of food allergy in the Mediterranean area, with peach allergy acting as the primary sensitizer in most cases. Lettuce has been described as a common offending food in patients with LTP syndrome. The aim of the study was to investigate the frequency and clinical expression of LTP syndrome in a sample of lettuceallergic patients. Methods: We determined specific IgE to Pru p 3 and lettuce in a sample of 30 patients with a diagnosis of lettuce allergy. Symptoms elicited by other LTP-containing plant-derived foods and the presence of cofactors were assessed. Results: The clinical symptoms of lettuce allergy were frequently severe, with 18 of the 30 patients experiencing anaphylaxis. All the patients had allergic reactions to other plant foods. Cofactors were involved in the clinical reactions of 13 of the 30 patients. Sensitization to pollens was found in 90% of patients. Conclusions: Lettuce allergy is found not as an isolated condition but in the context of LTP syndrome and it is characterized by severe reactions and frequent cofactor association.

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“…LTPs have also been described in pollens such as mugwort (Art v 3), plane tree (Pla a 3), Parietaria judaica (Par j 2) and olive tree (Ole e 7) pollens. However, these last two LTPs seem to have no cross-reactivity with allergenic plant food LTPs since Pru p 3 shares epitopes with LTPs from many fruits, nuts and vegetables, and even with mugwort, but not with Par j 2 [15] or Ole e 7 [16], suggesting that neither of these two pollens are linked to the LTP syndrome [17]. The existence of areas with a prevalence of plant food allergies where LTP sensitization is relevantly colocalized with LTP-enriched pollens suggests that pollinosis could trigger Pru p 3 sensitization [18,19,20].…”

Section: Introductionmentioning

confidence: 99%

Lipid Transfer Protein Syndrome in a Non-Mediterranean Area

Azofra

Berroa²,

Gastaminza³

et al. 2016

Int Arch Allergy Immunol

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Background: Plant food allergies associated with lipid transfer protein (LTP) have been widely described in the Mediterranean Basin. Objective: The aim of this work was to describe the clinical profile and pollen sensitization of plant food- allergic patients sensitized to LTP in a non-Mediterranean area. Methods: Patients with clear IgE-mediated symptoms associated with plant foods and a positive skin prick test (SPT) to Pru p 3 were included in a prospective study in the north of Spain. Reported symptoms were analyzed together with a battery of food and pollen SPTs and specific IgE components by ISAC microarray. Cross-inhibition studies were performed by ImmunoCAP with plane tree, mugwort and rPru p 3. Results: Among the 72 patients included, the most frequent food allergy reported was to peaches (69%) followed by nuts (walnuts 55%, peanuts 54% and hazelnuts 43%). Most patients suffered from symptoms with multiple plant foods (a median of 6 foods per patient). Regarding the patients' pollen sensitization, 36% were sensitized to mugwort pollen (72% showing sIgE to Art v 3), 33% to grass pollen and 24% to plane tree pollen (94% with sIgE to Pla a 3). Inhibition studies showed that specific IgEs against mugwort and plane tree pollen are inhibited by Pru p 3 in a strong manner, whereas Pru p 3 was less inhibited by pollen extracts. Conclusions: LTP syndrome occurs in a non-Mediterranean area and is related to multiple sensitizations to foods and pollens such as plane tree and mugwort. In these pollen sensitizations, Pru p 3 seems to be the primary sensitizer.

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Lipid transfer protein sensitization: reactivity profiles and clinical risk assessment in an Italian cohort

Cited by 106 publications

References 46 publications

Component-Resolved Diagnosis of Peanut Allergy and Its Possible Origins of Sensitization in China

Component-Resolved Diagnosis of Peanut Allergy and Its Possible Origins of Sensitization in China

Lettuce Allergy Is a Lipid Transfer Syndrome-Related Food Allergy With a High Risk of Severe Reactions

Lipid Transfer Protein Syndrome in a Non-Mediterranean Area

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