Lipid Tubule Self-Assembly: Length Dependence on Cooling Rate Through a First-Order Phase Transition

Thomas, Britt N.; Safinya, Cyrus R.; Plano, Robert J.; Clark, Noel A.

doi:10.1126/science.267.5204.1635

Cited by 191 publications

(202 citation statements)

References 23 publications

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“…The defect regions are stabilized by the segregation of SDS molecules to compensate the highmembrane curvature. As for a surfactant, its preferred packing [16][17][18][19][20] . The HGM molecule has similar area of head group and tail with CPP B1.…”

Section: Discussionmentioning

confidence: 99%

Novel polymer-free iridescent lamellar hydrogel for two-dimensional confined growth of ultrathin gold membranes

et al. 2014

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Hydrogels are generally thought to be formed by nano-to micrometre-scale fibres or polymer chains, either physically branched or entangled with each other to trap water. Although there are also anisotropic hydrogels with apparently ordered structures, they are essentially polymer fibre/discrete polymer chains-based network without exception. Here we present a type of polymer-free anisotropic lamellar hydrogels composed of 100-nm-thick water layers sandwiched by two bilayer membranes of a self-assembled nonionic surfactant, hexadecylglyceryl maleate. The hydrogels appear iridescent as a result of Bragg's reflection of visible light from the periodic lamellar plane. The particular lamellar hydrogel with extremely wide water spacing was used as a soft two-dimensional template to synthesize singlecrystalline nanosheets in the confined two-dimensional space. As a consequence, flexible, ultrathin and large area single-crystalline gold membranes with atomically flat surface were produced in the hydrogel. The optical and electrical properties were detected on a single gold membrane.

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Section: Discussionmentioning

confidence: 99%

Novel polymer-free iridescent lamellar hydrogel for two-dimensional confined growth of ultrathin gold membranes

et al. 2014

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“…Microtubules have a lumen diameter of approximately 0.5 mm and an average length of 20 45 mm, that provides large storage volume relative to the diameter. 71,74) They are stable in physiological solutions at 37oC for prolonged periods of time. 75,76) Lipid microtubules are safe, non-in‰ammatory and provide ease of site speciˆc delivery for proteins and peptides.…”

Section: Oil Suspensionsmentioning

confidence: 99%

Lipid Carriers: A Versatile Delivery Vehicle for Proteins and Peptides

2008

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Lipid based carriers have attracted increasing scientiˆc and commercial attention during the last few years as an alternative material for the delivery of peptides and proteins concerned with stability issues. This article presents an overview of diŠerent types of biocompatible and versatile lipid-based carriers employed for the delivery of therapeutic proteins and peptides. Such delivery systems are discussed and exempliˆed regarding both more traditional lipid based delivery systems such as liposomes and lipid emulsions as well as more novel structures, e.g., lipid microtubules, microbubbles, and solid lipid nanoparticles.

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“…It has been found that a variety of amphiphilies, including alkylaldonamides (3), diacetylenic phospholipids (4,5), amino acid-based surfactants (6,7), and multicomponent mixtures in bile (8,9), selfassemble into cylindrical tubules in solutions. Recently, advances have been made in controlling the sizes and shapes of tubules by adjusting the chemical compositions and the conditions under which self-assembly occurs (10)(11)(12)(13)(14)(15)(16).…”

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confidence: 99%

Liquid-crystal imaging of molecular-tilt ordering in self-assembled lipid tubules

Zhao

Mahajan

Lü

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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Self-assembled cylindrical tubules of chiral phospholipids are interesting supramolecular structures. Understanding the moleculartilt order is a key step in controlling the size and shape of the tubules and designing new functional materials. The current theories based on the chiral interactions, coupled with molecular tilt, have predicted that the tubules could have both uniform and modulated tilt states. Here, we image the molecular-tilt order in the self-assembled tubules of a chiral phospholipid by using liquid crystals as an optical amplification probe. We demonstrate that the organization of the molecular-tilt azimuth in the lipid tubules can induce an azimuthal orientation in the liquid crystals. Both uniform and modulated tilt states of the lipid tubules are observed after liquid-crystal optical amplification.liquid-crystal amplification ͉ molecular ordering ͉ self-assembly ͉ optical amplification ͉ supramolecular structure T he self-assembled cylindrical tubules have attracted considerable attention because of their interesting supramolecular structures and technological applications (1, 2). It has been found that a variety of amphiphilies, including alkylaldonamides (3), diacetylenic phospholipids (4, 5), amino acid-based surfactants (6, 7), and multicomponent mixtures in bile (8, 9), selfassemble into cylindrical tubules in solutions. Recently, advances have been made in controlling the sizes and shapes of tubules by adjusting the chemical compositions and the conditions under which self-assembly occurs (10-16).Theoretical models based on the chiral interactions, coupled with molecular tilt, have been used to explain the formation of the cylindrical tubules (17)(18)(19). In these models, the chiral molecules do not pack parallel to their neighbors but, rather, at a nonzero angle with respect to their neighbors. This chiral packing causes the twisting of a bilayer stripe, which leads to the formation of cylindrical tubules. The model by Selinger et al. (19) suggests that the tubules can have both uniform and modulated tilt states. In the uniform tilt state, the tubule has a constant orientation of the molecule tilt with respect to the equator of the cylinder (Fig. 1a). In the modulated tilt state, the tubule has a periodic modulated structure by helical stripes in the molecular tilted direction winding around the cylinder. The direction of the molecular tilt smoothly varies across the stripes and jumps at the edges of the stripes (Fig. 1b). These stripes in the tubules are suggested to be analogous to the tilted stripes seen in the Langmuir monolayers (20) but in a cylindrical rather than a planar geometry. To our knowledge, there has been no experimental test of the theoretical predictions because of the difficulty in probing the local direction of the molecular tilt in the tubules.In recent years, there has been an increased interest in developing an imaging technique based on liquid-crystal optical amplification for studying the structures and physical properties of organic and biological interfac...

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Lipid Tubule Self-Assembly: Length Dependence on Cooling Rate Through a First-Order Phase Transition

Cited by 191 publications

References 23 publications

Novel polymer-free iridescent lamellar hydrogel for two-dimensional confined growth of ultrathin gold membranes

Novel polymer-free iridescent lamellar hydrogel for two-dimensional confined growth of ultrathin gold membranes

Lipid Carriers: A Versatile Delivery Vehicle for Proteins and Peptides

Liquid-crystal imaging of molecular-tilt ordering in self-assembled lipid tubules

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