Lipid uptake by insect oocytes

Ziegler, Rolf; Antwerpen, Rik van

doi:10.1016/j.ibmb.2006.01.014

Cited by 202 publications

(186 citation statements)

References 98 publications

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“…Alternatively, uptake could occur as in Xenopus laevis oogenesis, where ferritin penetrates the basement membrane on the distal surface of the follicle cells and passes through channels between adjacent follicle cells into the vitelline envelope, and then to the surface of developing oocytes where it is incorporated by endocytosis (Dumont, 1978). Others have described uptake of large proteins into developing eggs in insects (Ziegler and Van Antwerpen, 2006). Further studies will be required to determine the origin of egg ferritin in mosquitoes.…”

Section: Discussionmentioning

confidence: 99%

Fate of blood meal iron in mosquitoes

Zhou

Kohlhepp

Geiser

et al. 2007

Journal of Insect Physiology

109

130

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Iron is an essential element of living cells and organisms as a component of numerous metabolic pathways. Hemoglobin and ferric-transferrin in vertebrate host blood are the two major iron sources for female mosquitoes. We used inductively coupled plasma mass spectrometry (ICP-MS) and radioisotope-labeling to quantify the fate of iron supplied from hemoglobin or as transferrin in Aedes aegypti. At the end of the first gonotrophic cycloe, ~87% of the ingested total meal heme iron was excreted, while 7% was distributed into the eggs and 6% was stored in different tissues. In contrast, 8% of the iron provided as transferrin was excreted and of that absorbed, 77% was allocated to the eggs and 15% distributed in the tissues. Further analyses indicate that of the iron supplied in a blood meal, ~7% appears in the eggs and of this iron 98% is from hemoglobin and 2% from ferrictransferrin. Whereas of iron from a blood meal retained in body of the female, ~97% is from heme and <1 % is from transferrin. Evaluation of iron-binding proteins in hemolymph and egg following intake of 59 Fe-transferrin revealed that ferritin is iron loaded in these animals, and indicate that this protein plays a critical role in meal iron transport and iron storage in eggs in A. aegypti.

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Section: Discussionmentioning

confidence: 99%

Fate of blood meal iron in mosquitoes

Zhou

Kohlhepp

Geiser

et al. 2007

Journal of Insect Physiology

109

130

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“…As insect eggs need to be provided with relatively large amounts of lipids stemming from exogenous sources (Kawooya and Law, 1988;Ziegler and Van Antwerpen, 2006), lipids may well be involved in triggering the increased reproductive output of fruit-fed females. Nevertheless, we could not detect any beneficial effect of adult-derived cholesterol or PUFAs on female survival and reproductive output.…”

Section: Effects On Longevity and Reproductionmentioning

confidence: 99%

“…Lipids, for instance, are likely to be of key importance for insect reproduction, as they are major constituents of the oocyte dry mass and serve various functions including their role as the main energy source for the developing embryo (Stanley-Samuelson and Loher, 1983;StanleySamuelson et al, 1988;Kawooya and Law, 1988;Svoboda, 1999;Ziegler and Van Antwerpen, 2006). As most insects are neither able to synthesize long-chain polyunsaturated fatty acids (hereafter PUFAs; but Blomquist et al, 1982;Beenakkers et al, 1985) nor the tetracyclic steroid nucleus required for the synthesis of sterols (Behmer and Nes, 2003) de novo, they depend on exogenous sources for successful development and reproduction (Al-Izzi and Hopkins, 1982;Beenakkers et al, 1985;Turunen, 1990;Behmer and Grebenok, 1998;Svoboda, 1999;Mondy and Corio-Costet, 2000).…”

Section: Introductionmentioning

confidence: 99%

Effects of adult nutrition on female reproduction in a fruit-feeding butterfly: The role of fruit decay and dietary lipids

Bauerfeind

Fischer

Hartstein

et al. 2007

Journal of Insect Physiology

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It was generally believed that butterflies and other holometabolous insects rely primarily on reserves accumulated during the larval stage for reproduction. Recent studies, however, highlight the often fundamental importance of adult nutrition to realize the full reproductive potential. While the importance of carbohydrates is fairly well understood, the role of most other adult-derived substances is only partially resolved. We here focus on the effects of dietary lipids (cholesterol, polyunsaturated fatty acids) and fruit decay (dietary yeast, ethanol) on female reproduction in the tropical, fruit-feeding butterfly Bicyclus anynana (Nymphalidae). We found that banana-fed control females outperformed all other groups fed on sucrose-based diets. Lipids, yeast or ethanol added to a sugar solution did not yield a similarly high reproductive output compared to fruit-fed females. Groups fed fresh or decaying banana showed no differences in reproductive performance. As we could not identify a single pivotal substance, we conclude that resource congruence (the use of nutrient types in a specified ratio) rather than any specific nutrient component is of key importance for maximum reproductive output. Further, dietary quality may affect egg hatching success in spite of no obvious effects on egg size and number. Thus, any implications about potential fitness effects of different diets need to consider egg (and hatchling) viability in addition to fecundity. r

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“…lipoproteins is a large molecule of ~ 210 kDa (4). In contrast to the reusable lipophorins, vitellogenins deliver lipids to oocytes via receptor-mediated endocytosis.…”

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confidence: 99%

Acquisition of Triacylglycerol Transfer Activity by Microsomal Triglyceride Transfer Protein during Evolution

Rava

Hussain

2007

Biochemistry

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Microsomal triglyceride transfer protein (MTP) is essential for the assembly of neutral lipid rich apolipoprotein B (apoB)-lipoproteins. Previously we reported that the Drosophila MTP transfers phospholipids but does not transfer triglycerides. In contrast, human MTP transfers both lipids. To explore the acquisition of triglyceride transfer activity by MTP, we evaluated amino acid sequences, protein structures, as well as the biochemical and cellular properties of various MTP orthologs obtained from species that diverged during evolution. All MTP orthologs shared similar secondary and tertiary structures, associated with protein disulfide isomerase, localized to the endoplasmic reticulum, and supported apoB secretion. While vertebrate MTPs transferred triglyceride invertebrate MTPs lacked this activity. Thus, triglyceride transfer activity was acquired during the transition from invertebrates to vertebrates. Within vertebrates, fish, amphibians, and birds displayed 27%, 40% and 100% triglyceride transfer activity compared to mammals. We conclude that MTP triglyceride transfer activity first appeared in fish and speculate that the acquisition of triglyceride transfer activity by MTP provided for a significant advantage in the evolution of larger and more complex organisms. KeywordsLipoproteins; apoB; MTP; triglycerides; evolution; phospholipids; vertebrates; invertebrates Distinct extracellular lipid transport systems that utilize lipoproteins evolved more than 900 million years ago. These include the apolipophorins circulating through the hemolymph of insects (1;2), vitellogenins of oviparous animals (3;4), and the apoB-lipoproteins secreted by vertebrates (5;6). In insects, hemolymph contains two lipid-containing particles, lipophorins, which exist as high density and low density particles, and lipid transfer particle (LTP). Both these particles are synthesized and secreted by cells; however, biochemical mechanisms involved in their biosynthesis have not been elaborated. Lipophorins acts as re-useable shuttle whereas the LTP loads and unloads lipids, mainly diacylglycerols, onto these particles. High density lipophorins contain two proteins lipophorin I (M r ~250 kDa) and II (M r ~70 kDa) that arise from proteolytic cleavage of a precursor protein. The low density lipophorin, in addition, contains lipophorin III (M r ~18 kDa) that is acquired during the loading of lipids to cover surface of the particles (2;4;7). LTP is a very high-density lipoprotein consisting of 14% lipid and three apolipoproteins, apoLTP-1, -II. -III of ~ 350, 85, and 60 kDa. Vitellogenins are female-specific lipoproteins synthesized intracellularly. The protein associated with these Correspondence: Phone: 718-270-4790; Fax: 718-270-2462, E-mail (20) and reduce the secretion of these particles both in cell culture as well as animal models (21;22). In humans, the absence of MTP activity results in abetalipoproteinemia, a disease characterized by the deficiency of plasma apoB and severely reduced lipid levels (23). Thus, the MTP lipi...

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Lipid uptake by insect oocytes

Cited by 202 publications

References 98 publications

Fate of blood meal iron in mosquitoes

Fate of blood meal iron in mosquitoes

Effects of adult nutrition on female reproduction in a fruit-feeding butterfly: The role of fruit decay and dietary lipids

Acquisition of Triacylglycerol Transfer Activity by Microsomal Triglyceride Transfer Protein during Evolution

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