Lipidome of mammographic breast density in premenopausal women

Getz, Kayla R.; Jeon, Myung Sik; Luo, Chongliang; Luo, Jingqin; Toriola, Adetunji T.

doi:10.1186/s13058-023-01725-1

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…Volumetric percent density (VPD) has emerged as a quantitative standard for assessing MBD. Previous study revealed that lipid species inversely associated with VPD predominantly belonged to the triacylglycerol ( N = 43) and diacylglycerol ( N = 7) sub-pathways [ 56 ]. These lipid species align with the protective effects observed in our research.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have predominantly explored triglycerides as a whole without specific subdivisions based on their structural forms. Hence, further research is warranted to identify which specific structural forms of triglycerides can exert preventive effects [ 56 ]. Our study highlights the potential importance of triglyceride subtypes in modulating BC risk, particularly in different molecular subtypes.…”

Section: Discussionmentioning

confidence: 99%

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The impact of lipidome on breast cancer: a Mendelian randomization study

Cao,

Ai,

Liu

2024

Lipids Health Dis

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Objective This study aims to investigate the association between specific lipidomes and the risk of breast cancer (BC) using the Two-Sample Mendelian Randomization (TSMR) approach and Bayesian Model Averaging Mendelian Randomization (BMA-MR) method. Method The study analyzed data from large-scale GWAS datasets of 179 lipidomes to assess the relationship between lipidomes and BC risk across different molecular subtypes. TSMR was employed to explore causal relationships, while the BMA-MR method was carried out to validate the results. The study assessed heterogeneity and horizontal pleiotropy through Cochran's Q, MR-Egger intercept tests, and MR-PRESSO. Moreover, a leave-one-out sensitivity analysis was performed to evaluate the impact of individual single nucleotide polymorphisms on the MR study. Results By examining 179 lipidome traits as exposures and BC as the outcome, the study revealed significant causal effects of glycerophospholipids, sphingolipids, and glycerolipids on BC risk. Specifically, for estrogen receptor-positive BC (ER+ BC), phosphatidylcholine (P < 0.05) and phosphatidylinositol (OR: 0.916–0.966, P < 0.05) within glycerophospholipids play significant roles, along with the importance of glycerolipids (diacylglycerol (OR = 0.923, P < 0.001) and triacylglycerol, OR: 0.894–0.960, P < 0.05)). However, the study did not observe a noteworthy impact of sphingolipids on ER+BC. In the case of estrogen receptor-negative BC (ER− BC), not only glycerophospholipids, sphingolipids (OR = 1.085, P = 0.008), and glycerolipids (OR = 0.909, P = 0.002) exerted an influence, but the protective effect of sterols (OR: 1.034–1.056, P < 0.05) was also discovered. The prominence of glycerolipids was minimal in ER-BC. Phosphatidylethanolamine (OR: 1.091–1.119, P < 0.05) was an important causal effect in ER−BC. Conclusions The findings reveal that phosphatidylinositol and triglycerides levels decreased the risk of BC, indicating a potential protective role of these lipid molecules. Moreover, the study elucidates BC's intricate lipid metabolic pathways, highlighting diverse lipidome structural variations that may have varying effects in different molecular subtypes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The impact of lipidome on breast cancer: a Mendelian randomization study

Cao,

Ai,

Liu

2024

Lipids Health Dis

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Aspirin Metabolites and Mammographic Breast Density in Premenopausal Women

Singh,

Getz,

Kyeyune

et al. 2024

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Studies investigating the associations of self-reported aspirin use and mammographic breast density (MBD) have reported conflicting results. We, therefore, investigated the associations of aspirin metabolites, with MBD in premenopausal women. Methods: We performed this study on 705 premenopausal women who had fasting blood draw for metabolomic profiling. We performed covariate-adjusted linear regression models to calculate the least squares means of volumetric measures of MBD (volumetric percent density (VPD), dense volume (DV), and non-dense volume (NDV)) by quartiles of aspirin metabolites (salicyluric glucuronide, 2-hydroxyhippurate (salicylurate), salicylate, and 2,6-dihydroxybenzoic acid). Results: Approximately 13% of participants reported taking aspirin in the past 12 months. Aspirin users had higher levels of 2-hydroxyhippurate (salicylurate), salicylate, and salicyluric glucuronide (peak area) than non-users, but only mean peak area of salicyluric glucuronide increased by both dose (1-2 tabs per day=1,140,663.7, and ≥3 tabs per day=1,380,476.0) and frequency (days per week: 1 day=888,129.3, 2-3 days=1,199,897.9 and ≥4 days=1,654,637.0). Aspirin metabolites were not monotonically associated with VPD, DV, or NDV. Conclusions: Given the null results, additional research investigating the associations of aspirin metabolites in breast tissue and MBD is necessary. Impact: Elucidating the determinants of MBD, a strong risk factor for breast cancer, can play an important role in breast cancer prevention. Future studies should determine the associations of non-aspirin non-steroidal anti-inflammatory drug metabolites with MBD.

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The Untapped Opportunities of Addressing Lifecourse Growth in Mammographic Breast Density and Breast Cancer Prevention in Non-Hispanic Black Women

Pourali,

Toriola

2024

Cancer Epidemiology, Biomarkers &Amp; Prevention

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This commentary discusses the importance of adiposity and lifecourse growth with mammographic breast density (MBD) in non-Hispanic Black (NHB) women. Although high MBD is a well-established risk factor for breast cancer, the determinants of MBD in NHB women remain understudied. Although adiposity at the time of mammography is most strongly associated with MBD, adiposity as early as ages 10 and 18 years is also independently associated with MBD. The commentary emphasizes the need for future research to identify biological mechanisms underlying the associations of adulthood adiposity and lifecourse growth with MBD in NHB women and how these can be translated to breast cancer prevention. Additionally, it highlights the need for more studies looking at lifecourse growth and microscopic breast tissue characteristics such as terminal duct lobular unit involution and epithelial-to-stromal proportions. See related article by Bigham et al., p. 1640

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Lipidome of mammographic breast density in premenopausal women

Cited by 5 publications

References 41 publications

The impact of lipidome on breast cancer: a Mendelian randomization study

The impact of lipidome on breast cancer: a Mendelian randomization study

Aspirin Metabolites and Mammographic Breast Density in Premenopausal Women

The Untapped Opportunities of Addressing Lifecourse Growth in Mammographic Breast Density and Breast Cancer Prevention in Non-Hispanic Black Women

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