2021
DOI: 10.1101/2021.12.10.472057
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Lipidomic analysis of adipose-derived extracellular vesicles reveals their potential as lipid mediators of obesity-associated metabolic complications

Abstract: Adipose extracellular vesicles (AdEV) transport lipids that could participate to the development of obesity-related metabolic dysfunctions. This study aimed to define mice AdEV lipid signature in either healthy or obesity context by a targeted LC-MS/MS approach. Distinct clustering of AdEV and visceral adipose tissue (VAT) lipidomes by principal component analysis reveals specific lipid composition of AdEV compared to source VAT. Comprehensive analysis identifies enrichment of ceramides and phosphatidylglycero… Show more

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“…Particularly, it could be evidenced that ADEVs were involved in the development of metabolic pathologies or in the low‐grade inflammation‐associated mechanisms 78 . Interestingly, the content of ADEVs appears to be modified in these pathological conditions including an enrichment of triacylglycerol content, 79 a modification of protein expression at the membrane surface, and a disruption of their miRNA content as described above 24,80 …”
Section: Role Of Ev‐containing Mirnas In Obesity and Metabolic Syndromementioning
confidence: 91%
“…Particularly, it could be evidenced that ADEVs were involved in the development of metabolic pathologies or in the low‐grade inflammation‐associated mechanisms 78 . Interestingly, the content of ADEVs appears to be modified in these pathological conditions including an enrichment of triacylglycerol content, 79 a modification of protein expression at the membrane surface, and a disruption of their miRNA content as described above 24,80 …”
Section: Role Of Ev‐containing Mirnas In Obesity and Metabolic Syndromementioning
confidence: 91%