Lipidomic Analysis of TRPC1 Ca2+-Permeable Channel-Knock Out Mouse Demonstrates a Vital Role in Placental Tissue Sphingolipid and Triacylglycerol Homeostasis Under Maternal High-Fat Diet

Bukowski, Michael R.; Singh, Brij B.; Roemmich, James N.; Larson, Kate

doi:10.3389/fendo.2022.854269

Cited by 2 publications

(1 citation statement)

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“…In alignment with the oxidative phenotype, muscular overexpression of PGC-1α in obese mice similarly reduced ceramide levels but increased mitochondria content and mitochondrial fatty-acid uptake [ 124 ]. Conversely, transgenic silencing of TRPC1 expression in mice was shown to elevate serum ceramide levels, corroborating a role for TRPC1 in cellular energy homeostasis [ 125 ]. These results clearly implicate oxidative muscle, and its propensity for fatty-acid oxidation, as a therapeutic target-tissue to control systemic ceramide levels.…”

Section: Adipogenic Consequences Of Elf-pemf Stimulationmentioning

confidence: 87%

The Developmental Implications of Muscle-Targeted Magnetic Mitohormesis: A Human Health and Longevity Perspective

Franco‐Obregón

Tai

et al. 2023

Bioengineering

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Muscle function reflects muscular mitochondrial status, which, in turn, is an adaptive response to physical activity, representing improvements in energy production for de novo biosynthesis or metabolic efficiency. Differences in muscle performance are manifestations of the expression of distinct contractile-protein isoforms and of mitochondrial-energy substrate utilization. Powerful contractures require immediate energy production from carbohydrates outside the mitochondria that exhaust rapidly. Sustained muscle contractions require aerobic energy production from fatty acids by the mitochondria that is slower and produces less force. These two patterns of muscle force generation are broadly classified as glycolytic or oxidative, respectively, and require disparate levels of increased contractile or mitochondrial protein production, respectively, to be effectively executed. Glycolytic muscle, hence, tends towards fibre hypertrophy, whereas oxidative fibres are more disposed towards increased mitochondrial content and efficiency, rather than hypertrophy. Although developmentally predetermined muscle classes exist, a degree of functional plasticity persists across all muscles post-birth that can be modulated by exercise and generally results in an increase in the oxidative character of muscle. Oxidative muscle is most strongly correlated with organismal metabolic balance and longevity because of the propensity of oxidative muscle for fatty-acid oxidation and associated anti-inflammatory ramifications which occur at the expense of glycolytic-muscle development and hypertrophy. This muscle-class size disparity is often at odds with common expectations that muscle mass should scale positively with improved health and longevity. Brief magnetic-field activation of the muscle mitochondrial pool has been shown to recapitulate key aspects of the oxidative-muscle phenotype with similar metabolic hallmarks. This review discusses the common genetic cascades invoked by endurance exercise and magnetic-field therapy and the potential physiological differences with regards to human health and longevity. Future human studies examining the physiological consequences of magnetic-field therapy are warranted.

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Section: Adipogenic Consequences Of Elf-pemf Stimulationmentioning

confidence: 87%