Lipidomic Profiling of Sinus Mucosa from Patients with Chronic Rhinosinusitis

Fazlollahi, Farbod; Kongmanas, Kessiri; Tanphaichitr, Nongnuj; Clair, Jon Mallen–St.; Gopen, Quinton; Faull, Kym F.; Suh, Jeffrey D.

doi:10.1111/cts.12256

Cited by 10 publications

(11 citation statements)

References 40 publications

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“…Metabolomics analysis of low molecular weight compounds (up to 1,500 Da) has been performed in CRS 83 . Fazlollahi et al found that fatty acids (palmitic, oleic, stearic, and lauric) were highly elevated in CRSwNP compared to CRSsNP and control tissues 86 . Miyata found impaired synthesis of cyclooxygenase-and lipoxygenase-derived mediators (including prostaglandin D 2 [PGD 2 ], PGE 2 , thromboxane B 2 , 15-hydroxyeicosatetraenoic acid and lipoxin A 4 ) and selective upregulation of leukotriene D4 in nasal polyp-derived eosinophils compared to healthy peripheral blood eosinophils 87 .…”

Section: Genomics Proteomics and Metabolomicsmentioning

confidence: 98%

Endotypes of Chronic Rhinosinusitis; relationships to disease phenotypes, pathogenesis, clinical findings and treatment approaches.

Kato¹,

Peters²,

Stevens³

et al. 2021

Preprint

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Chronic rhinosinusitis (CRS) is a common clinical syndrome that produces significant morbidity and costs to our health system. The study of CRS has progressed from an era focused on phenotype to include endotype based information. Phenotypic classification has identified clinical heterogeneity in CRS based on endoscopically observed features such as presence of nasal polyps, presence of comorbid or systemic diseases and timing of disease onset. More recently, laboratory-based findings have established CRS endotype based upon specific mechanisms or molecular biomarkers. Understanding the basis of widespread heterogeneity in the manifestations of CRS is advanced by findings that the three main endotypes, Type 1, 2 and 3, orchestrate the expression of three distinct large sets of genes. The development and use of improved methods of endotyping disease in the clinic is ushering in an expansion of the use of biological therapies targeting Type 2 inflammation now and perhaps other inflammatory endotypes in the near future. The purpose of this review is to discuss the phenotypic and endotypic heterogeneity of CRS from the perspective of advancing the understanding of the pathogenesis and improvement of treatment approaches and outcomes.

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Section: Genomics Proteomics and Metabolomicsmentioning

confidence: 98%

Endotypes of Chronic Rhinosinusitis; relationships to disease phenotypes, pathogenesis, clinical findings and treatment approaches.

Kato¹,

Peters²,

Stevens³

et al. 2021

Preprint

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“…Fazlollahi et al [22] demonstrated the application of an untargeted lipidomic study for the analysis of lipids, among other metabolites. The levels of fatty acids were, on average, 10-fold higher in CRS patients with concomitant NP growth compared to other groups, which suggested an altered lipid metabolism in the sinus mucosa samples.…”

Section: Chronic Rhinosinusitis (Crs)mentioning

confidence: 99%

“…Over the years, clinicians have identified several phenotypes of SA, based on the presentation, the age of onset of symptoms, the severity of the disease, and the presence of other conditions such as allergic status and/or eosinophilia, with different long-term outcomes, rate of exacerbations and response to therapy with corticosteroids [22].…”

Section: Biomarker Research In Type 2 Severe Asthmamentioning

confidence: 99%

Metabolomics, Microbiota, and In Vivo and In Vitro Biomarkers in Type 2 Severe Asthma: A Perspective Review

et al. 2021

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Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient; thus, it could be a new approach for the management of severe asthma that considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events. Metabolomics is the systematic study of low molecular weight (bio)chemicals in a given biological system and offers a powerful approach to biomarker discovery and elucidating disease mechanisms. In this point of view, metabolomics could play a key role in targeting precision medicine.

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“…Fazlollahi et al [ 21 ] demonstrated the application of an untargeted lipidomic study for the analysis of lipids among other metabolites. The authors assessed sinonasal tissue samples (sinus mucosa) from 9 patients with CRS with concomitant NP, 11 patients with CRS without polyps, and 12 healthy controls.…”

Section: Metabolomics In Searching For Crs-related Metabolitesmentioning

confidence: 99%

“…Many different bioinformatics tools have been developed to aid research in this field, such as optimizing the storage and accessibility of proteomic data or statistically ascertaining the significance of protein identification [ 19 , 20 ]. Based on metabolomic studies, the metabolic fingerprinting strategy [ 21 ], metabolic profiling, and quantitative targeted metabolomics are identified as useful in CRS development [ 22 , 23 ]. Each of the presented studies has utilized different strategies as well as specific, modern, highly sensitive analytical instrumentations.…”

Section: Introductionmentioning

confidence: 99%

An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development

Michalik¹,

Samet²,

Dmowska-Koroblewska³

et al. 2020

JPM

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Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinuses. It is defined as the presence of a minimum of two out of four main symptoms such as hyposmia, facial pain, nasal blockage, and discharge, which last for 8–12 weeks. CRS significantly impairs a patient’s quality of life. It needs special treatment mainly focusing on preventing local infection/inflammation with corticosteroid sprays or improving sinus drainage using nasal saline irrigation. When other treatments fail, endoscopic sinus surgery is considered an effective option. According to the state-of-the-art knowledge of CRS, there is more evidence suggesting that it is more of an inflammatory disease than an infectious one. This condition is also treated as a multifactorial inflammatory disorder as it may be triggered by various factors, such as bacterial or fungal infections, airborne irritants, defects in innate immunity, or the presence of concomitant diseases. Due to the incomplete understanding of the pathological processes of CRS, there is a continuous search for new indicators that are directly related to the pathogenesis of this disease—e.g., in the field of systems biology. The studies adopting systems biology search for possible factors responsible for the disease at genetic, transcriptomic, proteomic, and metabolomic levels. The analyses of the changes in the genome, transcriptome, proteome, and metabolome may reveal the dysfunctional pathways of inflammatory regulation and provide a clear insight into the pathogenesis of this disease. Therefore, in the present paper, we have summarized the state-of-the-art knowledge of the application of systems biology in the pathology and development of CRS.

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Lipidomic Profiling of Sinus Mucosa from Patients with Chronic Rhinosinusitis

Cited by 10 publications

References 40 publications

Endotypes of Chronic Rhinosinusitis; relationships to disease phenotypes, pathogenesis, clinical findings and treatment approaches.

Endotypes of Chronic Rhinosinusitis; relationships to disease phenotypes, pathogenesis, clinical findings and treatment approaches.

Metabolomics, Microbiota, and In Vivo and In Vitro Biomarkers in Type 2 Severe Asthma: A Perspective Review

An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development

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