Lipidomics and Health: an Added Value to Olive Oil

Ferreri, Carla; Chatgilialoglu, Chryssostomos

doi:10.1002/9781119135340.ch27

Cited by 1 publication

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“…They are also able to inhibit the activity of AKT protein, which is involved in cell survival and the inhibition of apoptotic processes [ 49 ]. Furthermore, PUFAs are involved in different processes such as lipid peroxidation, cell oxidative stress [ 50 , 51 ] and regulation of gene expression for controlling growth factor mediated carcinogenesis [ 52 ]. Moreover, there are other mechanisms involving lipid-based events that affect human health.…”

Section: Fatty Acids and Lipid Supply For Membrane Formation In Camentioning

confidence: 99%

Fatty Acids and Membrane Lipidomics in Oncology: A Cross-Road of Nutritional, Signaling and Metabolic Pathways

Ferreri

Sansone

Ferreri³

et al. 2020

Metabolites

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Fatty acids are closely involved in lipid synthesis and metabolism in cancer. Their amount and composition are dependent on dietary supply and tumor microenviroment. Research in this subject highlighted the crucial event of membrane formation, which is regulated by the fatty acids’ molecular properties. The growing understanding of the pathways that create the fatty acid pool needed for cell replication is the result of lipidomics studies, also envisaging novel fatty acid biosynthesis and fatty acid-mediated signaling. Fatty acid-driven mechanisms and biological effects in cancer onset, growth and metastasis have been elucidated, recognizing the importance of polyunsaturated molecules and the balance between omega-6 and omega-3 families. Saturated and monounsaturated fatty acids are biomarkers in several types of cancer, and their characterization in cell membranes and exosomes is under development for diagnostic purposes. Desaturase enzymatic activity with unprecedented de novo polyunsaturated fatty acid (PUFA) synthesis is considered the recent breakthrough in this scenario. Together with the link between obesity and cancer, fatty acids open interesting perspectives for biomarker discovery and nutritional strategies to control cancer, also in combination with therapies. All these subjects are described using an integrated approach taking into account biochemical, biological and analytical aspects, delineating innovations in cancer prevention, diagnostics and treatments.

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