Lipidomics, Biomarkers, and Schizophrenia: A Current Perspective

Sethi, Sumit; Hayashi, Mirian A. F.; Barbosa, Banny Silva; Pontes, João G. M.; Tasić, Ljubica; Brietzke, Elisa

doi:10.1007/978-3-319-47656-8_11

Cited by 21 publications

(14 citation statements)

References 61 publications

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“…For the other pathway showing an overall lipid concentration decrease in the three disorders, GP metabolism, lipid concentration decreases and increases were both reported in SZ [21,23,[25][26][27]62]. Our results indicate that, similar to eCB signaling, the disruption of GP metabolism might be a common feature of cognitive dysfunctions.…”

Section: Lipidome Changes In Cognitive Disorderssupporting

confidence: 63%

“…Lipid concentration changes were reported for specific lipid classes in many cognitive disorders, including SZ [21][22][23][24][25][26][27]62], ASD [19,20], DS [18], bipolar disorder [26,63], and Alzheimer's disease [64]. In our study, 27 SZ, 17 ASD and five DS patients samples were measured together with the control group in a random order.…”

Section: Lipidome Changes In Cognitive Disordersmentioning

confidence: 99%

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Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

Zubkov

et al. 2018

Mol Psychiatry

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Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 years, as well as 67 adult individuals diagnosed with autism (ASD), schizophrenia (SZ), and Down syndrome (DS). Of the 5024 detected lipids, 95% showed significant age-dependent concentration differences clustering into four temporal stages, and resulting in a gradual increase in membrane fluidity in individuals ranging from newborn to nonagenarian. Aging affects 14% of the brain lipidome with late-life changes starting predominantly at 50-55 years of age-a period of general metabolic transition. All three diseases alter the brain lipidome composition, leading-among other things-to a concentration decrease in glycerophospholipid metabolism and endocannabinoid signaling pathways. Lipid concentration decreases in SZ were further linked to genetic variants associated with disease, indicating the relevance of the lipidome changes to disease progression.

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Section: Lipidome Changes In Cognitive Disorderssupporting

confidence: 63%

Section: Lipidome Changes In Cognitive Disordersmentioning

confidence: 99%

Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

Zubkov

et al. 2018

Mol Psychiatry

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“…Together, serum and plasma are the second most commonly used biofluids in metabolomic studies after urine [34] The preanalytical stages of blood processing are different for plasma and serum. Anticoagulants are added to plasma vacutainers, and coagulation enhancers are added to serum vacutainers.…”

Section: Serum and Plasma Metabolome As A "Snapshot" Of A Human Biochemistrymentioning

confidence: 99%

Defining Blood Plasma and Serum Metabolome by GC-MS

et al. 2021

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Metabolomics uses advanced analytical chemistry methods to analyze metabolites in biological samples. The most intensively studied samples are blood and its liquid components: plasma and serum. Armed with advanced equipment and progressive software solutions, the scientific community has shown that small molecules’ roles in living systems are not limited to traditional “building blocks” or “just fuel” for cellular energy. As a result, the conclusions based on studying the metabolome are finding practical reflection in molecular medicine and a better understanding of fundamental biochemical processes in living systems. This review is not a detailed protocol of metabolomic analysis. However, it should support the reader with information about the achievements in the whole process of metabolic exploration of human plasma and serum using mass spectrometry combined with gas chromatography.

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“…Previous studies have investigated lipids in biofluids [e.g. blood, cerebrospinal fluid (CSF), urea, and plasma, serum] in patients with schizophrenia in comparison to control subjects and have identified schizophrenia-related lipid abnormalities 12 , 32 , 35 – 37 . Many of these studies were performed to investigate the membrane lipids in RBCs, as they are considered to represent the tissue lipid status due to several features 26 , 38 – 40 .…”

Section: Aberrant Lipidome In Schizophrenia As Revealed By Lipidomicsmentioning

confidence: 99%

Lipidomics of the brain, retina, and biofluids: from the biological landscape to potential clinical application in schizophrenia

et al. 2020

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Schizophrenia is a serious neuropsychiatric disorder, yet a clear pathophysiology has not been identified. To date, neither the objective biomarkers for diagnosis nor specific medications for the treatment of schizophrenia are clinically satisfactory. It is well accepted that lipids are essential to maintain the normal structure and function of neurons in the brain and that abnormalities in neuronal lipids are associated with abnormal neurodevelopment in schizophrenia. However, lipids and lipid-like molecules have been largely unexplored in contrast to proteins and their genes in schizophrenia. Compared with the gene- and protein-centric approaches, lipidomics is a recently emerged and rapidly evolving research field with particular importance for the study of neuropsychiatric disorders such as schizophrenia, in which even subtle aberrant alterations in the lipid composition and concentration of the neurons may disrupt brain functioning. In this review, we aimed to highlight the lipidomics of the brain, retina, and biofluids in both human and animal studies, discuss aberrant lipid alterations in correlation with schizophrenia, and propose future directions from the biological landscape towards potential clinical applications in schizophrenia. Recent studies are in support of the concept that aberrations in some lipid species [e.g. phospholipids, polyunsaturated fatty acids (PUFAs)] lead to structural alterations and, in turn, impairments in the biological function of membrane-bound proteins, the disruption of cell signaling molecule accessibility, and the dysfunction of neurotransmitter systems. In addition, abnormal lipidome alterations in biofluids are linked to schizophrenia, and thus they hold promise in the discovery of biomarkers for the diagnosis of schizophrenia.

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Lipidomics, Biomarkers, and Schizophrenia: A Current Perspective

Cited by 21 publications

References 61 publications

Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

Defining Blood Plasma and Serum Metabolome by GC-MS

Lipidomics of the brain, retina, and biofluids: from the biological landscape to potential clinical application in schizophrenia

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