Lipids and amyotrophic lateral sclerosis: A two‐sample Mendelian randomization study

Xia, Kailun; Klose, Veronika; Högel, Josef; Huang, Tao; Zhang, Linjing; Dorst, Johannes; Fan, Dongsheng; Ludolph, Albert C.

doi:10.1111/ene.15810

Cited by 13 publications

(2 citation statements)

References 47 publications

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“…Additionally, meat intake (processed meat intake, poultry intake, beef intake, pork intake and non-oily fish intake), staple food intake (bread intake and cereal intake), vegetables intake (cooked vegetable intake, salad/raw vegetable intake), fruits intake (dried fruit intake), beverage intake (tea intake) were not associated with ALS. There have been Mendelian Randomization analysis conducted on the potential risk or protective factors associated with ALS such as lipids, [ 27 ] alcohol drinking, [ 28 ] smoking, [ 29 ] and so on. However, there are few studies involving meat intake, staple food intake, fruit intake, vegetable intake, and beverage intake.…”

Section: Discussionmentioning

confidence: 99%

Dietary factors and risk for amyotrophic lateral sclerosis: A two sample mendelian randomization study

Jing,

Qi,

Teng

2024

Medicine

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Correlations between dietary factors and amyotrophic lateral sclerosis (ALS) have been found in previous observational studies. However, no further studies have used Mendelian randomization to further explore the causal relationship between dietary factors and ALS. Clarifying these relationships is a crucial part of developing nutritional recommendations for ALS prevention. The exposure and outcome datasets employed in this study were extracted from the IEU Open GWAS project (https://gwas.mrcieu.ac.uk/). The exposure datasets involved in our Mendelian analyses consisted of meat intake (processed meat intake, poultry intake, beef intake, pork intake, non-oily fish intake, and oily fish intake), staple foods intake (bread intake and cereal intake), vegetable intake (cooked vegetable intake, salad/raw vegetable intake), fruit intake (fresh fruit intake and dried fruit intake), and beverage intake (coffee intake and tea intake). The weighted median, MR-Egger, Inverse Variance Weighted, Simple mode and Weighted mode methods were all utilized. And we applied Inverse Variance Weighted method as the main judgement criterion for Mendelian randomization analysis. Heterogeneity and pleiotropy analyses were conducted to confirm the validity of the outcomes. Genetically predicted that oily fish intake (OR: 0.7648; 95% CI: 0.5905–0.9904; P = .0420), coffee intake (OR: 0.7385; 95% CI: 0.5660–0.9637; P = .0256), and fresh fruit intake (OR: 0.6165; 95% CI: 0.4007–0.9487; P = .0278) were causally associated with a decreased risk of ALS. Negative results (P > .05) were received for all other dietary factors. This study found that oily fish intake, coffee intake and fresh fruit intake reduced the risk of developing ALS. Additionally, other factors were not associated with ALS.

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Section: Discussionmentioning

confidence: 99%

Dietary factors and risk for amyotrophic lateral sclerosis: A two sample mendelian randomization study

Jing,

Qi,

Teng

2024

Medicine

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“…α-2-MRAP has a high affinity with LRP, preventing the binding of all other ligands and affecting the level of low-density lipoprotein cholesterol (LDL-C) (Zhang et al, 2017). An MR analysis showed elevated lipid levels are associated with an increased risk of ALS (Xia et al, 2023). However, although research shows that α-2-MRAP is associated with susceptibility to dementia, its relationship with ALS has not been studied.…”

Section: Discussionmentioning

confidence: 99%

Peripheral immune markers and amyotrophic lateral sclerosis: a Mendelian randomization study

Hu,

Zuo,

Mao

et al. 2023

Front. Neurosci.

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IntroductionThe peripheral immune system changes in amyotrophic lateral sclerosis (ALS), but the causal relationship between the two is still controversial.MethodsIn this study, we aimed to estimate the causal relationship between peripheral immune markers and ALS using a two-sample Mendelian randomization method. Genome-wide association study (GWAS) data on peripheral blood immune traits from European populations were used for exposure, and ALS summary statistics were used as the outcome. The causal relationship was evaluated by inverse variance weighting, MR-Egger, and weighted median methods and verified by multiple sensitivity analysis.ResultsWe found that the increase of one standard deviation of lymphocyte count is related to reducing ALS risk. CD3 on effector memory CD4+ T cell, HLA DR+ CD4+ T cell, effector memory CD8+ T cell, terminally differentiated CD8+ T cell and CD28- CD8+ T cell is also a protective factor for ALS. Among the circulating immune protein, the increase of one standard deviation of α-2-macroglobulin receptor-associated protein (α-2-MRAP) and C4b showed associated with low risk of ALS, while Interleukin-21 (IL-21) increases the risk of ALS.DiscussionOur study further reveals the important role of peripheral immune activity in ALS.

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Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study

Chourpiliadis,

Seitz,

Lovik

et al. 2024

J Neurol

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Background This study was an introduction to the Swedish ALSrisc Study and explored the association of lifestyle and medical conditions, with risk and progression of amyotrophic lateral sclerosis (ALS). Methods We included 265 newly diagnosed ALS patients during 2016–2022 in Stockholm and 207 ALS-free siblings and partners of the patients as controls. Information on body mass index (BMI), smoking, and history of head injuries, diabetes mellitus, hypercholesterolemia, and hypertension was obtained through the Euro-MOTOR questionnaire at recruitment. Patients were followed from diagnosis until death, invasive ventilation, or November 30, 2022. Results Higher BMI at recruitment was associated with lower risk for ALS (OR 0.89, 95%CI 0.83–0.95), especially among those diagnosed after 65 years. One unit increase in the average BMI during the 3 decades before diagnosis was associated with a lower risk for ALS (OR 0.94, 95%CI 0.89–0.99). Diabetes was associated with lower risk of ALS (OR 0.38, 95%CI 0.16–0.90), while hypercholesterolemia was associated with higher risk of ALS (OR 2.10, 95%CI 1.13–3.90). Higher BMI at diagnosis was associated with lower risk of death (HR 0.91, 95%CI 0.84–0.98), while the highest level of smoking exposure (in pack-years) (HR 1.90, 95%CI 1.20–3.00), hypercholesterolemia (HR 1.84, 95%CI 1.06–3.19), and hypertension (HR 1.76, 95%CI 1.03–3.01) were associated with higher risk of death, following ALS diagnosis. Conclusions Higher BMI and diabetes were associated with lower risk of ALS. Higher BMI was associated with lower risk of death, whereas smoking (especially in high pack-years), hypercholesterolemia, and hypertension were associated with higher risk of death after ALS diagnosis.

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Lipids and amyotrophic lateral sclerosis: A two‐sample Mendelian randomization study

Cited by 13 publications

References 47 publications

Dietary factors and risk for amyotrophic lateral sclerosis: A two sample mendelian randomization study

Dietary factors and risk for amyotrophic lateral sclerosis: A two sample mendelian randomization study

Peripheral immune markers and amyotrophic lateral sclerosis: a Mendelian randomization study

Lifestyle and medical conditions in relation to ALS risk and progression—an introduction to the Swedish ALSrisc Study

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