Lipids and hCRP concentrations in patients with dyslipidemia

Abstract

Disturbances in lipids, and inflammations plays a key role in the pathogenesis of all stages of atherosclerosis. The aim of present study was to investigate concentration of hCRP, lipids (TC, TG, LDL-C, nonHDL-C, HDL-C) and lipid ratios (TC/HDL-C, LDL-C/HDL-C, TG/HDL-C) in patients with moderate dyslipidemia and compared to the healthy subjects, and relation between hCRP and lipids and lipid ratios. We studied 40 patients with moderately dyslipidemia (male and female) at the age between 21-63 years and the reference group. The reference group constituted of 14 subjects chosen from normolipidemic healthy individuals. The patients with moderate dyslipidemia had significantly increased hCRP, TG, LDL-C levels and significantly increased lipid ratios (TG/HDL, LDL-C/HDL-C). The concentration of hCRP was significantly positively correlated with TG, TC, LDL-C, nonHDL-C concentrations and TG/HDL-C, LDL-C/HDL-C ratios. We concluded that chronic inflammation disease can disturb lipids concentration and can accelerate atherosclerosis. However, these results are required further studies.