Lipids and other risk factors selected by discriminant analysis in symptomatic patients with supra-aortic and peripheral atherosclerosis.

Vigna, Giovanni Battista; Bolzan, Mario; Romagnoni, F.; Valerio, G.; Vitale, E.; Zuliani, Giovanni; Fellin, Renato

doi:10.1161/01.cir.85.6.2205

Cited by 32 publications

(10 citation statements)

References 31 publications

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“…Also among the PVD patients, significantly higher blood levels of Apo B were measured, with total cholesterol concentrations that tended to be lower,.. Ns, than for the controls. This result is similar to findings of other authors (19,36,56) for PVD patients not selected according to their clinical stages. The Apo B increase could also suggest a change in the lipoprotein composition of LDL-C and VLDL-, with the appearance of Apo B-icher lipoproteins and, probably, more atherogenesis (36).…”

Section: No Significant Difference Between Pvd Patientssupporting

confidence: 92%

Arterial Damage, Triglycerides, Apolipoprotein, and Lp-(a) Values in PVD Patients

Catalano

Perilli

Carzaniga

et al. 1997

Clin Appl Thromb Hemost

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The aim of the study was to provide a detailed apolipoproteic profile in stage II peripheral vascular disease (PVD) patients and to ascertain whether lower ankle/ arm pressure index (API) values were associated with a worse profile.Apolipoproteins of 83 stage II PVD patients (average age 64.7 & p l u s m n ; 9.3 years) were selected and compared with those of a group of 44 normal control subjects, similar in terms of age, sex, and smoking and eating habits. Neither PVD patients nor controls had ever received lipidlowering agents or defined dietary treatment. A diagnosis of PVD was confirmed by an API of <0.85. Arteriopathic patients were also split into two groups, depending on their API values, similar in terms of age, sex and smoking habits: API values of one group (n = 38) were ≥0.6, those of the other group (n = 45) were <0.6. The following biohumoral parameters were considered: fasting glycemia, total cholesterol, triglycerides (TGs)

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Section: No Significant Difference Between Pvd Patientssupporting

confidence: 92%

Arterial Damage, Triglycerides, Apolipoprotein, and Lp-(a) Values in PVD Patients

Catalano

Perilli

Carzaniga

et al. 1997

Clin Appl Thromb Hemost

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“…In Japanese working population-based cohort study, Tomita reported that hyperuricemia had a strong association with death in all causes, coronary heart disease, stroke, hepatic disease and renal failure (5). These results indicate that SUA may also be a marker indicating risk of advanced arterial disease as well as an early marker of atherosclerosis such as carotid IMT (24).…”

Section: Discussionmentioning

confidence: 78%

Association between Uric Acid and Carotid Atherosclerosis in Elderly Persons

et al. 2005

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Objective Several cohort studies have shown a link between serum uric acid (SUA) and subsequent cardiovascular disease. However, such an association did not remain significant after adjusting for concomitant risk factors for atherosclerosis in some studies. Thus, the role of SUA as an independent risk factor remains controversial. We therefore investigated the association between SUA and sclerotic lesions of common carotid atherosclerosis.Patients and Methods We evaluated sclerotic lesions of the common carotid arterial intima-media thickness (IMT) by ultrasonography in 398 men aged 74±8 (range, 60-97) years and 521 women aged 75±8 (range, 60-104) years. To investigate the relation between SUA and various factors, all subjects were divided into three groups based on the tertile of SUA.Results Stepwise multiple linear regression analysis using IMT as an objective variable, adjusted by various risk factors as explanatory variables showed that SUA [B, 0.0099; 95% confidence interval (CI), 0.0022-0.0175] was a significant independent contributing factor along with known risk factors such as age, sex, smoking status, systolic blood pressure, diastolic blood pressure, antihypertensive drug use, HDL-cholesterol, and LDLcholesterol. Multiple logistic regression analysis for carotid IMT as a tertile of SUA and dependent variables showed that the adjusted odds ratio was 1.25 (95% CI, 0.87-1.78) for those in the middle tertile (4.2-5.5 mg/dl), and 1.66 (95% CI, 1.16-2.39) for those in the highest tertile (5.6-14.1 mg/dl) compared to that for subjects in the lowest tertile of SUA levels (0.51-4.1 mg/dl).Conclusion We suggest that SUA is a risk factor or marker for ultrasonographically determined IMT.

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“…Hyperuricemia was more frequent in those with abnormal angiograms, and uric acid levels were related to lipoprotein abnormalities. Moreover, studies performed with carotid ultrasound 29 or angiography 30,31 have suggested that there is a linear relationship between carotid atherosclerosis and hyperuricemia.…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid Is a Strong Predictor of Stroke in Patients With Non–Insulin-Dependent Diabetes Mellitus

Lehto

Niskanen

Rönnemaa

et al. 1998

Stroke

365

222

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Background and Purpose-Patients with non-insulin-dependent diabetes mellitus (NIDDM) are at increased risk for stroke.Hyperuricemia is a common finding in NIDDM, but its significance as an independent risk factor for cardiovascular disease has remained uncertain. Therefore, we investigated serum urate as a predictor of stroke in NIDDM patients free of clinical nephropathy (ie, with a serum creatinine level of Յ120 mol/L). Methods-In this population-based study, cardiovascular risk factors were determined in 1017 patients (551 men and 466 women) with NIDDM, aged 45 to 64 years at baseline. The patients were followed up for 7 years with respect to stroke events.

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Lipids and other risk factors selected by discriminant analysis in symptomatic patients with supra-aortic and peripheral atherosclerosis.

Abstract: Risk profiles in atherosclerosis of the supra-aortic trunks and lower limbs seem to differ in relation to gender and circulatory district involved. The importance of lipid parameters, in particular HDL-C, HDL2-C, and TC/HDL-C, as extracoronary risk factors is further confirmed.

Cited by 32 publications

References 31 publications

Arterial Damage, Triglycerides, Apolipoprotein, and Lp-(a) Values in PVD Patients

Arterial Damage, Triglycerides, Apolipoprotein, and Lp-(a) Values in PVD Patients

Association between Uric Acid and Carotid Atherosclerosis in Elderly Persons

Serum Uric Acid Is a Strong Predictor of Stroke in Patients With Non–Insulin-Dependent Diabetes Mellitus

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