Lipids of human atheroma VI. Hydrocarbons of the atheromatous plaque

Brooks, C. J. W.; Steel, G. Gordon; Harland, W. A.

doi:10.1007/bf02531974

Cited by 11 publications

(4 citation statements)

References 29 publications

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“…Several authors have reported the presence of different classes of hydrocarbons (linear, branched and isoprenoid) in animal tissue (1)(2)(3)(4), human tissue (5)(6)(7), microorganisms (8)(9)(10), milk fat and seed oil (11)(12)(13), and wheat flour (14). Although the origin of hydrocarbons in animal tissues has not yet been elucidated, they are thought to be derived either from natural biosynthetic processes (15), environmental pollution, or the use of paraffins and mineral oils in food technology.…”

Section: Introductionmentioning

confidence: 99%

“…Although the metabolic role and biological significance of hydrocarbons have not been clarified, their presence has been associated with several human pathological conditions, such as splenic follicular lipidosis (16), human atherosclerotic plaques (7,17) and neoplastic tissues (5). More recently, the cocarcinogenic and tumor-promoting activities of n-alkanes have been studied in relation to possible effects on membrane transport processes (18,19).…”

Section: Introductionmentioning

confidence: 99%

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Distribution of hydrocarbons in bovine tissues

Lintas

Balduzzi

Bernardini

et al. 1979

Lipids

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Liver, heart, kidneys, muscle and adipose (perirenal and subcutaneous) tissues were collected from six animals for analysis of their hydrocarbon composition. Qualitative and quantitative determinations were carried out by gas chromatography and combined gas chromatography-mass spectrometry. Although differing in the proportions, a homologous series of n-alkanes ranging from n-C12 to n-C31 was found in all the samples examined. The isoprenoid hydrocarbons phytane and phytene (phy-1-ene and phyt-2-ene) were also identified.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distribution of hydrocarbons in bovine tissues

Lintas

Balduzzi

Bernardini

et al. 1979

Lipids

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“…Saturated hydrocarbons have been associated with a human pathological condition called splenic follicular lipidosis, characterized by abnormal accumulation of paraffinic hydrocarbons in the spleen up to 16.3% of the total lipids (5). Gazzarrini and Nagy (13) and Brooks et al (14) identified n-alkanes in human atherosclerotic plaques. Various types of hydrocarbons were detected in the fat globule membrane of human and bovine milk (15), in rat liver cell membranes (3), and in all human serum lipoprotein classes, with the highest relative amount (4.4% of the total lipid) in the ultracentrifugal residue (16).…”

Section: Introductionmentioning

confidence: 99%

Tissue variation in hydrocarbon composition in the rabbit

Ferretti

Flanagan

1977

Lipids

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This study, which deals with the distribution of hydrocarbons in seven types of rabbit tissues, was done for the purpose of providing information that might help shed light on the biological relevance of the hydrocarbons in mammalian metabolism. Liver, kidneys, brain, spleen, skeletal muscle, perinephric adipose, and a sample of blood serum were collected from a single animal for analysis of their hydrocarbon composition. The analytical methodology consisted of solvent extraction, saponification (adipose), elution chromatography on hydrated alumina, and combined gas chromatography-mass spectrometry. Hydrocarbons were detected in all of the tissues examined at concentrations estimated to range from 0.1 to 0.01% of the total lipid extracted Three quite distinct distribution modes were recognized. The bulk of the identified components consisted of normal, saturated, nonterpenoid hydrocarbons in the C16 to C33 range. Squalene, phytene, phytadiene, and pristane were the only terpenoids detected. Nonterpenoid branched (iso and anteiso) hydrocarbons were identified unequivocally and in significant amounts in the muscle only. The adipose was the only tissue which was relatively rich in monoalkenes, and its overall hydrocarbon composition closely resembled that of the feed. The results of the study are not consistent with metabolic inertness. The observed qualitative and quantitative differences might reflect function and metabolic activities of the individual organs in a way yet to be elucidated.

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“…They have been found as minor constituents of mammalian brain [4], human arterial tissue and plaques [5,6], meninges and meningiomas [71.…”

Section: Introductionmentioning

confidence: 99%