2022
DOI: 10.21203/rs.3.rs-2164365/v1
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Lipo-MGN Nanoparticle Hypoxia Attenuation Mediated Single-dose Radiotherapy and pH/ROS Responsive T1 Contrast Magnetic Resonance Imaging in Hepatocellular Carcinoma

Abstract: Tumour hypoxia is an important factor for developing resistance to radiation therapy (RT) and present a bleak prognosis in cancer patients undergoing treatment for RT resistant hepatocellular carcinoma. Here, we present the synthesis of liposome-coated Mn3O4 (MGN) nanoparticles (Lipo-MGN) and investigation of their therapeutic potential with RT utilizing a HepG2 cancer model. According to in-vitro research, Lipo-MGN effectively produced oxygen in the presence of H2O2 and significantly reduced the expression of… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 28 publications
(23 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?