Lipoblastoid/signet‐ring cell‐rich Spitz nevus: a hitherto unreported microscopic variant

Salviato, Tiziana; Luzar, Boštjan; Falconieri, Giovanni

doi:10.1111/cup.12370

Cited by 3 publications

(2 citation statements)

References 4 publications

(1 reference statement)

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“…7 Signet-ring melanocytes are characterized by an empty cytoplasmic vacuole displacing the nucleus to one side of the cell 6,7 or lipoblast-like in Spitz nevus with one or more clear spaces indenting the nuclei. 8 By contrast, the intracytoplasmic elastic fibers in elastophilic melanocytic nevus appeared as solid grayish/bluish material filling the cytoplasm of the melanocytes. In the ultrastructural study by Ono, true phagocytosis was not demonstrated in dermal melanocytoses, and the elastic fibers were never shown to be within the cytoplasm of the dendritic melanocytes.…”

Section: Discussionmentioning

confidence: 97%

Melanocytic Nevus With Elastophilic Features

Tran¹

2022

The American Journal of Dermatopathology

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:In dermal melanocytoses such as blue nevus or nevus of Ota, an ultrastructural study has demonstrated an intimate relationship between the dendritic melanocytes and the dermal elastic fibers with elongated cytoplasmic processes of the melanocytes aligning lengthwise along the axis of the elastic fibers in longitudinal sections and encircling the elastic fibers in cross-sections. Such a close arrangement has not been reported in common melanocytic nevi. The current case described a similar arrangement between the melanocytes and the dermal elastic fibers in a usual intradermal melanocytic nevus. Of note, as the melanocytes matured with descent, the deep melanocytes were arranged in single cells embracing the elastic fibers, imparting a signet-ring cell/phagocytosis appearance. A Verhoeff—van Gieson stain showed hypertrophy of the melanocyte-associated elastic fibers compared with the elastic fibers in the dermal background, suggesting a paracrine or juxtracrine interaction between the melanocytes and the dermal cellular components. Because of the distinctive affinity of the melanocytes to the dermal elastic fibers in this melanocytic lesion, the term melanocytic nevus with elastophilic features is suggested for this peculiar melanocytic variant.

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Section: Discussionmentioning

confidence: 97%

Melanocytic Nevus With Elastophilic Features

Tran¹

2022

The American Journal of Dermatopathology

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“…As nodularity leads to pinching of the epidermis and keratinocyte proliferation of varying degrees, transepidermal elimination may attempt to eliminate the entire nevus [52] or may attempt to remove the nevus in a piecemeal fashion, leading to a bumpy surface. Transepidermal elimination may not occur at all, or may be partly impeded, if there was impaired neurocutaneous development in association with prenatal nevogenesis [9].…”

Section: Discussionmentioning

confidence: 99%

The High Multiplicity of Prenatal (Congenital Type) Nevi in Adolescents and Adults

2016

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In the absence of work on prenatal nevogenesis, it has long been necessary to define congenital melanocytic nevi by clinical detection on neonatal skin examination. They are seen in approximately 1% of newborns, with multiplicity in approximately 3% of cases. Melan-A staining of grossly normal fetal skin recently demonstrated fetal nevi, whose features validated certain traditional histologic criteria for "congenital type" nevi that may not have been detectable at birth. This suggested that many clinically acquired nevi actually formed in utero, like congenital nevi. Prenatal nevi has been suggested as a preferred synonym for "congenital type" nevi. Prenatal nevi were detected in 6 of 25 fetuses (24%), a strikingly higher incidence than congenital nevi in newborns. In this series of 354 patients with prenatal (congenital type) nevi encountered in routine practice at a community hospital, over 30% of both adolescents and adults had multiple prenatal nevi; a strikingly higher rate of multiplicity than congenital nevi in newborns. This high multiplicity may reflect origin beneath the epidermis, with many prenatal nevi working their way up to the surface of the skin decades after birth.

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Unusual Histopathological Patterns in Melanocytic Nevi With Some Previously Undescribed Patterns

Fernández-Flores

Cassarino

2016

The American Journal of Dermatopathology

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Melanocytic nevi are one of the most common diagnoses in the daily practice of any dermatopathologist. Although in the vast majority of cases the final diagnosis is not difficult, there are certain rare and unusual morphologic variations that can elicit some diagnostic problems. Although some of these variations can be considered as mere morphologic oddities, others might lead to a differential diagnosis with melanoma, or with other tumors, including epithelial or neural tumors. In the current report, we review many of these morphologic variations and discuss the main differential diagnosis, when appropriate.

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Lipoblastoid/signet‐ring cell‐rich Spitz nevus: a hitherto unreported microscopic variant

Cited by 3 publications

References 4 publications

Melanocytic Nevus With Elastophilic Features

Melanocytic Nevus With Elastophilic Features

The High Multiplicity of Prenatal (Congenital Type) Nevi in Adolescents and Adults

Unusual Histopathological Patterns in Melanocytic Nevi With Some Previously Undescribed Patterns

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