Lipoblastoma: a rare lesion in the differential diagnosis of childhood mediastinal tumors

Salem, R.; Zohd, M.; Njim, Leïla; Maazoun, K.; Jellali, M.A.; Zrig, A.; Mnari, Walid; Harzallah, W.; Nouri, Anass; Zakhama, A.; Mondher, Golli

doi:10.1016/j.jpedsurg.2011.01.030

Cited by 14 publications

(7 citation statements)

References 9 publications

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“…Clinically, these lipoblastomas are described as a painless mass with respiratory symptoms. Neurologic symptoms (paraparesis due to spinal cord compression) are rare [2,[4][5][6][7][8]. In general, lipoblastoma is circumscribed, wellencapsulated and confined to the subcutis.…”

Section: Discussionmentioning

confidence: 99%

First Report of a Large Mediastinal Lipoblastoma and its Complete Resection in an Adult: Case Report

Schweckendiek

Bode‐Lesniewska

Frauenfelder

et al. 2020

SN Compr. Clin. Med.

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We present the unusual case of a 25-year-old female with shortness of breath, concomitant cough and a palpable mass in the left lower neck. The patient underwent thoracotomy via clamshell incision to remove the mass of preoperative unknown aetiology. A preoperative biopsy was inconclusive. Histology surprisingly revealed a lipoblastoma. The patient is without evidence of tumour relapse after 60 months. The lipoblastoma is a neoplasm of the embryonic adipose tissue. Typically, it is seen in the extremities and the trunk of children up to 3 years of age (Coffin et al. (Am J Surg Pathol 33:1705-12, 2009); Kok and Telisinghe (World J Surg 34:1517-22, 2010; De Saint Aubain Somerhausen et al. (Histopathology 52:294-98, 2008)). Appearances in adults are very rare. Age and location could have been therefore misleading in this patient. Surgeon, pulmonologist, radiologist and pathologist must be aware that this entity can also be found in the mediastinum of adults.

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Section: Discussionmentioning

confidence: 99%

First Report of a Large Mediastinal Lipoblastoma and its Complete Resection in an Adult: Case Report

Schweckendiek

Bode‐Lesniewska

Frauenfelder

et al. 2020

SN Compr. Clin. Med.

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“…Lipomas, fairly uncommon during the first two decades of life, usually arise in the extremities and trunk, 4 while lipoblastomas occur most frequently in male children younger than 3 years, with common locations reported to be the trunk, neck, and extremities. 5 6 A liposarcoma is an extremely unusual tumor in pediatric patients, accounting for less than 3% of all pediatric sarcomas, and usually occurs in the retroperitoneum and extremities. 7 …”

Section: Discussionmentioning

confidence: 99%

“…The most important issue in clinical practice is to determine whether the tumor is a lipoma, because lipoblastoma and liposarcoma have been reported to show rapid growth, along with a high recurrence rate and poor prognosis. 2 3 5 6 7 Lipoblastoma recurrence has been noted in 14 to 25% of reported cases, 6 usually because of incomplete resection or diffuse disease. Most pediatric liposarcoma have a myxoid characteristic and prognosis for conventional myxoid liposarcomas is good as compared with other types.…”

Section: Discussionmentioning

confidence: 99%

Rare Lipomatous Tumor of the Posterior Mediastinum in Children

Homma

Doki

Senda

et al. 2014

Eur Jnl Ped Surg Reports

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The mediastinum is a unique anatomic area containing various structures and pluripotent cells, which allow for the development of a range of tumors. We report two pediatric cases of a lipomatous tumor of the posterior mediastinum. Complete surgical excision of the mass in each was achieved through a lateral thoracotomy. Histopathologic findings showed a lipoma in one case and a lipoblastoma in the other. A lipomatous tumor in the posterior mediastinum is extremely rare and preoperative diagnosis is difficult. When an operative plan is being considered, the presence of a potentially malignant tumor should be kept in mind.

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“…Lipoblastoma, a relatively rare tumor of embryonal fat, is characterized by its benign nature, early presentation (90 % <3 years) [ 18 ], male predominance of 3:1 [ 19 ], and rapid growth. Although it is found most commonly in the trunk or upper and lower extremities [ 1 ], the involvement of the other lesion (e.g., head/neck [ 2 ], mediastinum [ 3 ], mesentery [ 4 ], omentum [ 5 ], retroperitoneum, and scrotum (Table 1 ) [ 7 – 16 ]) has been reported. The differential diagnoses of pediatric intrascrotal paratesticular tumor include benign tumors (e.g., lipoma, lipoblastoma, leimomyoma, and hemangioma) and malignant tumors (e.g., rhabdomyosarcoma, liposarcoma, and melanotic neuroectodermal tumor of infancy (MNTI)) [ 15 , 20 ].…”

Section: Case Presentationmentioning

confidence: 99%

“…It is found most commonly in the trunk or upper and lower extremities as a painless nodule or mass [ 1 ]. Less common sites of involvement include the head and neck area [ 2 ], mediastinum [ 3 ], mesentery [ 4 ], omentum [ 5 ], retroperitoneum [ 6 ], and scrotum [ 7 – 16 ]. The accurate preoperative diagnosis is difficult because of its rarelity and the similarity with the other soft tissue tumors [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Intrascrotal lipoblastoma: report of a case and the review of literature

et al. 2016

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Intrascrotal lipoblastoma is a rare pediatric benign soft tissue neoplasm, and only 11 cases have been reported. The accurate preoperative diagnosis is difficult because of its rarelity and the similarity with the other soft tissue tumors. Among them, accurate preoperative diagnosis had been made in only one case. Thus, almost all of the cases had required inguinal mass excision (and orchidectomy in one case). In this paper, we discuss the accurate preoperative diagnosis of intrascrotal lipoblastoma and subsequent simple tumorectomy via minimal invasive scrotal skin incision, in 1-year-old boy. On physical examination, intrascrotal extra-testicular lobulated mass was palpated on the right scrotum. An ultrasonography revealed the well-circumscribed, iso-echoic, scant blood-flow, and lobulated tumors with each lobules of 1 to 4 cm in diameter, and the tumor located outside of the tunica vaginalis testis. The serum values of alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (b-hCG) were within normal limit. The preoperative diagnosis of intrascrotal lipoblastoma was made, and the mass was excised via minimal scrotal incision. The right testicle and epididymis were normal. The lesion consisted of the distinct two lobulated tumors, and microscopic examination confirmed the diagnosis of intrascrotal lipoblastoma. The postoperative course was uneventful without evidence of recurrence. A rare intrascrotal lipoblastoma is seldom made accurate preoperative diagnosis; however, the accurate preoperative suspicion of this tumor leads to the minimal invasive tumorectomy via scrotal skin incision and favorable postoperative recovery without recurrence.

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Lipoblastoma: a rare lesion in the differential diagnosis of childhood mediastinal tumors

Cited by 14 publications

References 9 publications

First Report of a Large Mediastinal Lipoblastoma and its Complete Resection in an Adult: Case Report

First Report of a Large Mediastinal Lipoblastoma and its Complete Resection in an Adult: Case Report

Rare Lipomatous Tumor of the Posterior Mediastinum in Children

Intrascrotal lipoblastoma: report of a case and the review of literature

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