Lipoblastoma of the abdominal wall

Chromothripsis in lipoblastoma: second reported case with complex PLAG1 rearrangement

“…Over 80% of LPBs are diagnosed in children before three years of age with some present at birth and may show a male predilection [ 13 – 16 ]. The most affected regions are subcutaneous tissue of the extremities, but other locations include the head and neck [ 8 ], pelvis [ 17 , 18 ], mediastinum [ 8 , 19 ], mesentery [ 20 ], axilla [ 21 ], and abdomen [ 6 , 19 , 22 ]. A subset of patients diagnosed with LPB have developmental delays, seizures, familial lipoma syndromes, and congenital malformations such as cleft lip, cleft palate, cephalic malformations, seizures [ 1 , 12 , 23 ].…”

Scrotal Lipoblastoma with Radiological and Histological Correlation

“…MRI is the next modality to consider in cases that are inconclusive on US, and is the gold standard for determining the composition and extent of tumor. 9 10 17 MRI usually demonstrates heterogeneous intensity on T2- and T1-weighted imaging (T2WI and T1WI), owing to its variable portion of mature fat. 9 15 17 There is marked heterogeneous enhancement of the nonfat portion on MRI, similar to CEUS.…”

“… 9 10 17 MRI usually demonstrates heterogeneous intensity on T2- and T1-weighted imaging (T2WI and T1WI), owing to its variable portion of mature fat. 9 15 17 There is marked heterogeneous enhancement of the nonfat portion on MRI, similar to CEUS. 15 Hibernomas have similar MR appearance of increased signal intensity, not quite equal to subcutaneous fat, with increased vascularity that may be well demonstrated on MR angiography.…”

“… 13 MRI of rhabdomyosarcoma has characteristic but nonspecific findings, and demonstrates intermediate to hypointense signal on T1WI, and intermediate to hyperintense signal on T2WI, with marked enhancement. 7 15 17 MRI with fat suppression can be helpful in cases of diagnostic uncertainty between rhabdomyosarcoma and adipocytic tumors, as adipocytic tumors will show an attenuated signal. 6 If rhabdomyosarcoma is suspected, MRI should be performed to determine the stage of disease before surgery.…”