2023
DOI: 10.1111/1753-0407.13504
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Lipocalin 2—A bone‐derived anorexigenic and β‐cell promoting signal: From mice to humans

Yuying Yang,
Jianmin Liu,
Stavroula Kousteni

Abstract: The skeleton is traditionally known for its structural support, organ protection, movement, and maintenance of mineral homeostasis. Over the last 10 years, bone has emerged as an endocrine organ with diverse physiological functions. The two key molecules in this context are fibroblast growth factor 23 (FGF23), secreted by osteocytes, and osteocalcin, a hormone produced by osteoblasts. FGF23 affects mineral homeostasis through its actions on the kidneys, and osteocalcin has beneficial effects in improving gluco… Show more

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