2008
DOI: 10.4049/jimmunol.181.12.8521
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Lipocalin 2-Dependent Inhibition of Mycobacterial Growth in Alveolar Epithelium

Abstract: Mycobacterium tuberculosis invades alveolar epithelial cells as well as macrophages. However, the role of alveolar epithelial cells in the host defense against M. tuberculosis remains unknown. In this study, we report that lipocalin 2 (Lcn2)-dependent inhibition of mycobacterial growth within epithelial cells is required for anti-mycobacterial innate immune responses. Lcn2 is secreted into the alveolar space by alveolar macrophages and epithelial cells during the early phase of respiratory mycobacterial infect… Show more

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Cited by 129 publications
(148 citation statements)
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References 42 publications
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“…The siderophore-chelating property of Lcn2 renders it a bacteriostatic agent (20). Consistent with this finding, Lcn2 mutant mice have a profound defect in the defense against E. coli (19,31) and Mycobacterium tuberculosis (32). Nonetheless, Lcn2 expression dramatically increases in several aseptic pathological conditions such as cancers (33), inflammatory diseases (34), and acute kidney injury (24), suggesting that Lcn2 may have other functions.…”
Section: Discussionsupporting
confidence: 61%
“…The siderophore-chelating property of Lcn2 renders it a bacteriostatic agent (20). Consistent with this finding, Lcn2 mutant mice have a profound defect in the defense against E. coli (19,31) and Mycobacterium tuberculosis (32). Nonetheless, Lcn2 expression dramatically increases in several aseptic pathological conditions such as cancers (33), inflammatory diseases (34), and acute kidney injury (24), suggesting that Lcn2 may have other functions.…”
Section: Discussionsupporting
confidence: 61%
“…The role of Lcn2 as part of the innate immune system defense against bacteria and pathogens is becoming better defined (Flo et al, 2004;Saiga et al, 2008;Chan et al, 2009;Nairz et al, 2009). However, its role in other inflammatory diseases and traumatic injuries has not been thoroughly examined.…”
Section: Discussionmentioning
confidence: 99%
“…The ATP level was not dramatically altered in any region of the small intestinal tissues between wild-type and Entpd7 2/2 mice. Because Entpd7 is highly expressed in ECs of the small intestine, we established intestinal EC lines from wild-type and Entpd7 2/2 mice using transgenic mice harboring a temperature-sensitive mutation of the SV40 large tumor Ag gene under the control of an IFN-ginducible H-2K b promoter element to analyze ATP levels in the ECs (26,35,36). ECs from wild-type and Entpd7 2/2 mice expressed keratin proteins equally as well as Krt7 mRNA, indicating that these cells are ECs (Supplemental Fig.…”
Section: Selective Expression Of Entpd7 In Small Intestinal Epitheliamentioning
confidence: 99%