Lipofuscin and lipofuscin-like substances

Tsuchida, Masako; Toshiyuki, Miura; Aibara, Kageaki

doi:10.1016/0009-3084(87)90055-7

Cited by 104 publications

(58 citation statements)

References 133 publications

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“…FLS are derived from some secondary products formed during lipid peroxidation, and are widely measured as a parameter of lipid peroxidation. 24) In this study, FLS showed the same tendency as TBARS, and was significantly decreased by BWHE treatment in the erythrocyte ( pϽ0.005), liver ( pϽ 0.05) and brain ( pϽ0.005). The heart TBARS and FLS levels tended to be lower in the BWHE group than in the Control group.…”

Section: Changes Of Lipid Peroxide Level and Sod Like Activity In Thesupporting

confidence: 61%

Antioxidant Activities of Buckwheat Hull Extract toward Various Oxidative Stress in Vitro and in Vivo.

Mukoda

Sun

Ishiguro

2001

Biological & Pharmaceutical Bulletin

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Section: Changes Of Lipid Peroxide Level and Sod Like Activity In Thesupporting

confidence: 61%

Antioxidant Activities of Buckwheat Hull Extract toward Various Oxidative Stress in Vitro and in Vivo.

Mukoda

Sun

Ishiguro

2001

Biological & Pharmaceutical Bulletin

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“…According to their method, the lipids were extracted from the heads of spin and wild-type flies and fluorescence spectra of the lipid extracts were then measured. The lipid extracts from the heads of spin flies had an excitation maximum at 368 nm and an emission maximum at 450 nm; these are characteristic of those observed with the lipofuscin pigments (13,38,42) (Fig. 4).…”

Section: Vol 21 2001mentioning

confidence: 73%

Mutations in the Novel Membrane Protein Spinster Interfere with Programmed Cell Death and Cause Neural Degeneration inDrosophila melanogaster

Nakano

Fujitani

Kurihara

et al. 2001

Molecular and Cellular Biology

127

169

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Mutations in the spin gene are characterized by an extraordinarily strong rejection behavior of female flies in response to male courtship. They are also accompanied by decreases in the viability, adult life span, and oviposition rate of the flies. In spin mutants, some oocytes and adult neural cells undergo degeneration, which is preceded by reductions in programmed cell death of nurse cells in ovaries and of neurons in the pupal nervous system, respectively. The central nervous system (CNS) of spin mutant flies accumulates autofluorescent lipopigments with characteristics similar to those of lipofuscin. The spin locus generates at least five different transcripts, with only two of these being able to rescue the spin behavioral phenotype; each encodes a protein with multiple membrane-spanning domains that are expressed in both the surface glial cells in the CNS and the follicle cells in the ovaries. Orthologs of the spin gene have also been identified in a number of species from nematodes to humans. Analysis of the spin mutant will give us new insights into neurodegenerative diseases and aging.

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“…Oxidative damage and neuronal degeneration mediated by seizures partially contribute to the formation of lipofuscin in the hippocampus (40). Associated with this observation comes the hypothesis that oxidative stress could be one of the primary factors in the accumulation of lipofuscin (41)(42)(43)(44)(45)(46)(47). Several reports have demonstrated that lipofuscin deposits represent the accumulation of the peroxidative action of free radical on membrane lipid, resulting at a considerably earlier age than for normal mice (9,10,28,48).…”

Section: Discussionmentioning

confidence: 99%

Effect of Monascus-Fermented Products on Learning and Memory in the SAMP8 Mice

Wang

Yang

et al. 2007

J Nutr Sci Vitaminol

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SummaryThe purpose of this study was to evaluate the impact of Monascus -fermented products (MP) as regards certain changes in behavior for SAMP8 mice. Both male and female SAMP8 mice were fed a 0.03% MP diet from 3 mo of age to 11 mo of age. The results indicated that the grading score of passive avoidance behavior was significantly lower in the MP diet groups than in the control diet groups in both male and female SAMP8 mice ( p Ͻ 0.05). The MP diet-augmented test-animal body weight, feed intake and feed efficiency did not differ significantly from the corresponding values for control mice. The MP diet-fed mouse group revealed significantly improved learning and memory as revealed by average escape-response testing score when comparing with control mice ( p Ͻ 0.05). Further, the level of serum triglyceride and total cholesterol for the MP-fed group were shown to be significantly lower than for the control group of SAMP8 mice at 11 mo of age. The test mice fed an MP diet appeared to be significantly lower in aging score than the control group ( p Ͻ 0.05). The MP diet-fed mouse group revealed significantly improved total antioxidation of liver. Subsequent to supplementation of SAMP8 mice diets with MP for a period of 8 mo, these MP-fed mice revealed significantly lower lipofuscin-cell numbers within the hippocampus ( p Ͻ 0.05). The results suggest that dietary supplementation with MP might improve both learning and memory behaviour, and retard the aging process for SAMP8 mice.

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Lipofuscin and lipofuscin-like substances

Cited by 104 publications

References 133 publications

Antioxidant Activities of Buckwheat Hull Extract toward Various Oxidative Stress in Vitro and in Vivo.

Antioxidant Activities of Buckwheat Hull Extract toward Various Oxidative Stress in Vitro and in Vivo.

Mutations in the Novel Membrane Protein Spinster Interfere with Programmed Cell Death and Cause Neural Degeneration inDrosophila melanogaster

Effect of Monascus-Fermented Products on Learning and Memory in the SAMP8 Mice

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