Lipofuscin

Jung, Tobias; Bader, Nicolle; Grune, Tilman

doi:10.1196/annals.1404.008

Cited by 377 publications

(274 citation statements)

References 153 publications

(246 reference statements)

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“…The lipofuscin pigment results from peroxidation and may have negative effects on cellular function (Jung et al 2007). Its presence indicates decreased efficiency of cellular metabolic processes which may be indicative of membrane damage or mitochondrial/lysomal damage.…”

Section: Discussionmentioning

confidence: 99%

Gravity Receptor Aging in the CBA/CaJ Strain: A Comparison to Auditory Aging

Mock

Jones

2010

JARO

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The CBA/CaJ mouse strain is commonly used as a control as it has no known genetic mutations affecting the inner ear, maintains hearing sensitivity throughout life, and serves as a background for creating new genetic strains. The purpose of the present study was to characterize the effects of age and gender on gravity receptor function and compare functional changes between auditory and vestibular modalities. Vestibular-evoked potentials (VsEPs), auditory brainstem responses (ABRs), and distortion product otoacoustic emissions were measured in 131 mice. VsEP thresholds deteriorated an average of 0.39 dB re: 1.0 g/ms per month and at the oldest ages (18-23 months old) showed an average loss of 49% of VsEP dynamic range. No significant gender differences were found for VsEPs. ABR thresholds increased by an average of 1.35, 1.38, and 1.15 dB pe SPL per month for ABR stimulus frequencies of 8, 16, and 32 kHz, respectively, demonstrating an average decrease in auditory dynamic range of 25-35% at advanced ages. Both modalities declined with age. Age-related decreases in gravity receptor sensitivity should be considered when using the CBA/CaJ strain for vestibular studies.

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Section: Discussionmentioning

confidence: 99%

Gravity Receptor Aging in the CBA/CaJ Strain: A Comparison to Auditory Aging

Mock

Jones

2010

JARO

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“…Severe oxidized and cross-linked proteins have reached the third stage of oxidative modification and are not longer accessible for proteolytic degradation. Such proteins tend to build hydrophobic and insoluble aggregates and are preliminary stages of the socalled lipofuscin (35)(36)(37), an indegradable and nonexocytosable material; in the literature sometimes also referred to as ''age pigment'' (38) or ''ceroid'' (39). If the proteolytic systems of the cell (40)(41)(42) fail to degrade oxidized proteins in time, the likelihood of cross-linking events increases and lipofuscin is formed.…”

Section: Protein Oxidation In Mammalian Cellsmentioning

confidence: 99%

“…finally in a self-catalyzing formation of lipofuscin (37). Lipofuscin is continuously accumulated in lysosomes, thus decreasing besides proteasomal also lysosomal protein turnover (36,46).…”

Section: Protein Oxidation In Mammalian Cellsmentioning

confidence: 99%

The proteasome and its role in the degradation of oxidized proteins

2008

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SummaryThe generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidized proteins have to be removed in order to prevent serious metabolic disturbances. The most important cellular proteolytic system responsible for the removal of oxidized proteins is the proteasomal system. For normal functioning, the proteasomal system needs the coordinated interaction of numerous components. This review describes the fundamental functions of the 20S ''core'' proteasome, its regulators, and the roles of the proteasomal system beyond the removal of oxidized proteins in mammalian cells. IUBMBIUBMB Life, 60(11): 743-752, 2008

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“…There is gradual and steady accumulation of this intracellular yellow-brown fluorescent pigment & is considered as a hallmark of aging [16].…”

Section: Many Substances Have Been Identified That Act As Biomarkers mentioning

confidence: 99%