Lipokalina związana z żelatynazą neutrofilów jako marker ostrego uszkodzenia nerek u chorych onkologicznych leczonych cisplatyną

Szumilas, Dawid; Wojnar, Jerzy; Chudek, Jerzy

doi:10.5603/njo.2016.0025

Cited by 4 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NGAL molecule is found in 3 isoforms: monomeric (25 kDa), dimeric (45 kDa), and as heterodimeric (135 kDa-complexed with gelatinase) [49]. The gene for this protein is located on chromosome 9 and this molecule is expressed in renal, liver, endothelial, smooth muscle cells, neurons, and cells of immune system (macrophages and dendritic cells) [50][51][52]. NGAL molecule expresses its action via a primary ligand, siderophore and metalloproteinase 9 (MMP-9) and is present in plasma as well as urine [4,49].…”

Section: Neutrophil Gelatinase-associated Lipocalin (Ngal) (Aka: Uter...mentioning

confidence: 99%

Role of Urine Examination in Renal Transplant Recipients

K. Nigam

2024

Advances and Challenges in Urine Laboratory Analysis

View full text Add to dashboard Cite

Kidney transplantation has emerged as a major advance of modern medicine, providing high-quality life years to patients with end-stage renal disease (ESRD). Post-transplant monitoring of the transplanted kidney is based on physical examination, urine volume, the assessment of albuminuria or proteinuria, serum creatinine, and glomerular filtration rate (GFR) estimation based on serum creatinine. Of these multiple investigations, serum creatinine and urine analysis is one of the most widely used and accepted tool to assess graft dysfunction as well as plan management. Various immunological (rejections-antibody, cellular) and non-immunological (polyoma virus nephropathy, mycosis, recurrent/de novo diseases) may affect the graft function. Changes in various parameters like urine osmolality, proteinuria, hematuria and presence of casts, crystals and other cellular constituents aids in diagnosis diseases of the allograft. This chapter thus highlights the importance of most frequent parameters that help in assessing the graft function. In addition to these parameters, a brief introduction of biomarkers is also included. Many studies have shown that these biomarkers have a promising role in diagnosis of allograft disease and thus avoiding interventional procedures like renal biopsy. Easy availability as well as low-cost of the urine examination makes it a promising tool for overall assessment of the graft dysfunction.

show abstract

Section: Neutrophil Gelatinase-associated Lipocalin (Ngal) (Aka: Uter...mentioning

confidence: 99%

Role of Urine Examination in Renal Transplant Recipients

K. Nigam

2024

Advances and Challenges in Urine Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…NGAL is secreted by the cells of the proximal kidney tubule, the ascending limb of the Henle loop and the collecting duct. NGAL, present in urine, is produced in the lungs, liver and leukocytes (including leukocytes that infiltrate kidneys) as a response to the inflammation process [25], which is a disadvantage of this biomarker. Nevertheless, combined with other specific renal biomarkers (such as KIM-1), urine NGAL concentrations may provide additional information about the extent of kidney tissue damage.…”

Section: Introductionmentioning

confidence: 99%

The Utility of Novel Kidney Injury Biomarkers in Early Detection of CSA-AKI

Udzik

Waszczyk

Wojciechowska‐Koszko

et al. 2022

IJMS

View full text Add to dashboard Cite

Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most common complications of cardiac surgery procedures. In this study, the authors attempt to provide new data regarding the application of novel kidney injury biomarkers in the early diagnostics of CSA-AKI. 128 adult patients undergoing elective cardiac surgery procedures with the use of cardiopulmonary by-pass (CPB) were enrolled in this study. Novel kidney injury biomarkers were marked in the plasma and urine 6 h after weaning from the CPB. A significant difference in the postoperative biomarkers’ concentration between the AKI and no-AKI group was found, regarding plasma IL-8, plasma TNF-α and urine NGAL, normalized for creatinine excretion (NGAL/Cr). These were also independent predictors of CSA-AKI. An independent risk factor for CSA-AKI proved to be preoperative CKD. Plasma IL-8 and TNF-α, as well as urine NGAL/Cr, are independent early indicators of CSA-AKI and pose a promising alternative for creatinine measurements. The cut-off points for these biomarkers proposed in this investigation should be confronted with more data and revised to achieve a suitable diagnostic value.

show abstract

“…Both NGAL and KIM-1 are highly specific kidney injury biomarkers, which are produced by the structures of the nephron in response to its damage [ 7 , 8 ]. NGAL appears in urine after 3 h from kidney injury, peaks at 6 h and maintains elevated for a longer time period stimulating tissue regeneration [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment and Prognosis in CSA-AKI Using Novel Kidney Injury Biomarkers: A Prospective Observational Study

Udzik

Waszczyk

Safranow

et al. 2021

Biology

View full text Add to dashboard Cite

Background: There is a need for early diagnostic solutions for cardiac surgery associated acute kidney injury (CSA-AKI) as serum creatinine changes do not occur dynamically enough. Moreover, new approaches are needed for kidney protective strategy in patients undergoing cardiac surgery procedures; Methods: Samples of serum and urine were taken from the selected group of patients undergoing elective cardiac surgery procedures. The aim of this study was to assess the utility of specific inflammation and kidney injury biomarkers in the early diagnostic of CSA-AKI and in the prognosis of long-term postoperative kidney function; Results: At 6 h after weaning from cardiopulmonary bypass, there were significant differences in IL-6, IL-8, TNF-α, MMP-9 and NGAL concentrations in patients with CSA-AKI, compared to the control group. Serum IL-8 and urine NGAL 6 h after weaning from CPB proved to be independent acute kidney injury predictors. The TNF-α, MMP-9, IL-18, TIMP-1 and MMP-9/TIMP-1 ratio in the early postoperative period correlated with long-term kidney function impairment; Conclusions: Novel kidney injury biomarkers are an eligible tool for early diagnosis of CSA-AKI. They are also reliable indicators of long-term postoperative kidney function impairment risk after cardiac surgery procedures.

show abstract

Lipokalina związana z żelatynazą neutrofilów jako marker ostrego uszkodzenia nerek u chorych onkologicznych leczonych cisplatyną

Cited by 4 publications

References 33 publications

Role of Urine Examination in Renal Transplant Recipients

Role of Urine Examination in Renal Transplant Recipients

The Utility of Novel Kidney Injury Biomarkers in Early Detection of CSA-AKI

Assessment and Prognosis in CSA-AKI Using Novel Kidney Injury Biomarkers: A Prospective Observational Study

Contact Info

Product

Resources

About