Lipolytic catecholamine resistance linked to α2-adrenoceptor sensitivity—a metabolic predictor of weight loss in obese subjects

Hellström, Lena; Rössner, Stephan; Hagström-Toft, E; Reynisdottir, Signy

doi:10.1038/sj.ijo.0800407

Cited by 33 publications

(19 citation statements)

References 7 publications

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“…was more striking in untrained obese subjects with higher adipocyte volume than in untrained nonobese subjects, and Hellström et al have shown that, after weight loss during very low-calorie diet, ␣ 2 -AR sensitivity decreased (16). However, when obese subjects were trained for 3 mo, although their weight did not change, the antilipolytic effect of ␣ 2 -AR in vitro was decreased (6); this illustrates the effect of training on AR activity.…”

Section: Discussionmentioning

confidence: 96%

Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men

Glisezinski

Moro

Pillard

et al. 2003

American Journal of Physiology-Endocrinology and Metabolism

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re. Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men. Am J Physiol Endocrinol Metab 285: E984-E990, 2003; 10.1152/ ajpendo.00152.2003.-The aim of this study was to investigate whether endurance training improves lipid mobilization and oxidation in overweight subjects. Eleven young men (25.6 Ϯ 1.4 yr and body mass index 27.7 Ϯ 0.2) performed a 4-mo training program consisting of practicing aerobic exercise 5 days/wk. Before and after the training period, lipid oxidation was explored during a 60-min exercise at 50% of peak O2 consumption by use of indirect calorimetry. Lipid mobilization and antilipolytic ␣2-adrenoceptor effect were also studied using the microdialysis method in abdominal subcutaneous adipose tissue (SCAT). After training, plasma nonesterified fatty acid (NEFA) levels, at rest and during exercise, were significantly lower than before (P Ͻ 0.001). Lipolysis in SCAT was significantly higher after than before training. An antilipolytic ␣2-adrenoceptor effect in SCAT was underlined during exercise before training and disappeared after. The respiratory exchange ratio was lower after training, i.e., the percentage of lipid oxidation was higher only at rest. The amount of lipid oxidized was higher after training, at rest, and during exercise. Although exercise power was higher after training, the relative intensity was equivalent, as suggested by a similar increase in plasma catecholamine concentrations before and after training. In conclusion, 4-mo training in overweight men improved lipid mobilization through a decrease of antilipolytic ␣ 2-adrenoceptor effect in SCAT and lipid oxidation during moderate exercise. Training induced a decrease of blood NEFA, predicting better prevention of obesity. subcutaneous adipose tissue; microdialysis; catecholamines; ␣ 2-adrenoceptor; exercise; lipid oxidation REGULAR EXERCISE ASSOCIATED WITH DIET has been recommended as an important strategy in the prevention and management of obesity. Endurance training appears to be one of the major factors determining the long-term success of weight loss programs (26, 37). One explanation is that exercise partly counteracts the decline in fat oxidation occurring with weight loss during a hypocaloric diet by maintaining adipose lipolytic responsiveness (25, 36).In normal-weight subjects exercise training has been found to result in increased fat oxidation (3), but whole body lipolysis during exercise was not significantly enhanced by training (20).Few studies bear on the effect of exercise on adipose tissue lipolysis in obese subjects, whereas in this population an alteration of catecholamine-stimulated lipolysis has been reported (28,29). In a previous study, we have shown that 3-mo aerobic training in obese men enhanced the lipolytic ␤-adrenergic response of adipose tissue and decreased adipocyte antilipolytic activity of ␣ 2 -adrenoceptors (AR) in vitro (6); moreover, we have shown in vivo that lipolysis at rest was increased during ␤-adrenergic stimulation after physical t...

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Section: Discussionmentioning

confidence: 96%

Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men

Glisezinski

Moro

Pillard

et al. 2003

American Journal of Physiology-Endocrinology and Metabolism

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“…8,9 However, a reduced sensitivity to the lipolytic effect of catecholamines has been evidenced in young obese; 10 more importantly, the individual responsiveness to the catecholamine-induced lipolysis is predictive of the rate of body weight loss, during energy restriction. 11 From all these data, it clearly appears that the SNS is sensitive to both positive and negative energy balance. Moreover, an impaired capacity of the SNS to adapt to modifications of energy balance could either contribute to the development of obesity and/or hamper body weight loss.…”

Section: Introductionmentioning

confidence: 93%

Relationship between sympathetic reactivity and body weight loss in morbidly obese subjects

et al. 2004

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OBJECTIVE:To investigate the possible role of peripheral sympathetic activity in gastric bypass-induced body weight loss. SUBJECTS AND METHODS:In 42 morbidly obese patients (sex: 36 f/6 m; BMI: 46.070.7 kg/m 2 ) undergoing a gastric bypass, the skin vasoconstrictor reflex in answer to a deep inspiration was measured by laser Doppler fluximetry. The extent of vasoconstriction, measured at the second finger of the left hand, was expressed as percent reduction of the basal blood flux (% vasoconstriction). Insulin sensitivity was assessed before surgery in a subset of patients (n ¼ 11), by the method of euglycemic, hyperinsulinemic clamp. Body weight and composition were evaluated before, and 3, 6 and 12 months after surgery. At the same time points, energy intake (kJ/day) was evaluated by means of both food record diary and alimentary anamnesis. RESULTS: The % vasoconstriction, which was significantly (P ¼ 0.01) greater in normoglycemic subjects than in diabetic ones, was also significantly (P ¼ 0.03) related to the extent of insulin sensitivity measured during the euglycemic clamp. The % vasoconstriction showed a significant (P40.0001), positive correlation with weight reduction obtained between the 6th and 12th months following surgery; as a consequence, % vasoconstriction was significantly (P ¼ 0.0004) related to the overall body weight loss achieved during the year following the operation. These correlations remained significant in multiple regression analysis with adjustment for age, initial body weight, plasma glucose and insulin (P ¼ 0.0007 and 0.006, respectively). The % vasoconstriction was also significantly (P ¼ 0.0006), negatively related to energy intake measured 12 months after surgery. CONCLUSIONS: In conditions of stable body weight, the sympathetic nervous system (SNS) reactivity is influenced by the degree of insulin resistance. A high capacity to activate the SNS, measured before surgery, is associated with both a larger gastric bypass-induced weight loss and a lower energy intake, at the phase of weight stabilization.

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“…www.e-jkmr.org 91 Hellström 28) also found that plasma NA and α 2 -adrenergic receptor sensitivity are associated with weight loss during 4 weeks on diet restriction. These three studies suggest that plasma NA can be used as a prognostic marker for treating obesity.…”

Section: Discussion»»»mentioning

confidence: 96%

“…These findings show that constitutional differences in ANS activity may explain the variability in weight loss observed by obese subjects 17) . Nevertheless, it is insufficient to show that the ANS can predict the propensity to lose weight in obese individuals, and all interventions in those studies [26][27][28] were dietary restriction.…”

Section: Discussion»»»mentioning

confidence: 99%

The Correlation Analysis between Heart Rate Variability and Effect of Acupuncture on Obese Women

Kim¹,

Yang²,

Kim³

et al. 2016

Journal of Korean Medicine Rehabilitation

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Objectives The purpose of this study was to investigate the relationship between the effects of acupuncture treatment and heart rate variability (HRV) in pre-menopausal obese women. Methods Thirty-seven obese women who met the inclusion criteria were recruited. To estimate the effects of acupuncture, obesity indices, such as body weight (BW), waist circumference (WC), hip circumference (HC), and the waist-hip ratio (WHR), were measured before and after the treatment. The HRV test was conducted before treatment and analyzed using the frequency domain method. Results The lnLF/HF ratio (natural logarithm of low frequency power/high frequency power ratio of the HRV value) before treatments was negatively correlated with differences in WC, HC, and WHR during treatment. The correlation coefficients between the lnLF/HF ratio and the differences in WC, HC, and WHR were r=−0.459 (p＜0.01), r=−0.327 (p＜0.05), and r=−0.339 (p＜0.05) respectively. Conclusions As the baseline ratio of sympathetic activity to parasympathetic activity decreases, WC, HC, and WHR reduction significantly increased during treatment. Further study is needed to uncover the relationship between obesity-related variables and the autonomic nervous system to predict the effect of acupuncture. (J Korean Med Rehabil 2016;26(4):85-96)

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Lipolytic catecholamine resistance linked to α2-adrenoceptor sensitivity—a metabolic predictor of weight loss in obese subjects

Cited by 33 publications

References 7 publications

Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men

Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men

Relationship between sympathetic reactivity and body weight loss in morbidly obese subjects

The Correlation Analysis between Heart Rate Variability and Effect of Acupuncture on Obese Women

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