Lipoma of the tongue diagnosed by fine‐needle aspiration cytology

Caputo, Alessandro; Crescenzo, Rosa Maria Di; Landolfi, Luciano; Zeppa, Pio

doi:10.1002/dc.24459

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…In the procedure known as rapid on-site evaluation (ROSE), the cytopathologist can smear the material on glass slides, air-dry them, stain them with a quick cytological stain (such as Diff-Quik) and evaluate them for adequacy on the spot, using a microscope [ 86 , 87 , 88 , 89 ]. While a morphological diagnosis can be rendered directly in some cases, the most important thing is that ROSE allows the cytopathologist to perform two crucial steps: sampling can be repeated on the spot if the first smears are inadequate or non-diagnostic, thus greatly reducing the rate of inadequate diagnoses, patient anxiety, and diagnostic delay; by integrating clinical, imaging (ultrasonography, computed tomography) and microscopic cytologic data, the material can be allocated in the best way possible [ 90 , 91 , 92 ]. For example, in suspect lymphoproliferative disorders, some material may be saved in phosphate-buffered saline (PBS) to perform flow cytometry [ 93 ], and in lymph nodal metastases of unknown primary, some material can be fixed in formalin to prepare a cell block for accurate immunohistochemical phenotyping [ 93 , 94 , 95 , 96 ].…”

Section: Discussionmentioning

confidence: 99%

Testing EGFR with Idylla on Cytological Specimens of Lung Cancer: A Review

Caputo

D'Ardia

Sabbatino

et al. 2021

IJMS

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The current standard of care for advanced non-small-cell lung cancer is based on detecting actionable mutations that can benefit from targeted therapy. Comprehensive genetic tests can have long turn-around times, and because EGFR mutations are the most prevalent actionable mutation, a quick detection would enable a prompt initiation of targeted therapy. Furthermore, the scarcity of diagnostic material means that sometimes only cytologic material is available. The Idylla™ EGFR assay is a real-time PCR–based method able to detect 51 EGFR mutations in 2.5 h. Idylla is validated for use only on FFPE sections, but some researchers described their experiences with cytological material. We reviewed the relevant literature, finding four articles describing 471 cases and many types of cytological input material: smears, cell-block sections, suspensions, and extracted DNA. The sensitivity, specificity, and limit of detection appear comparable to those obtained with histological input material, with one exception: the usage of scraped stained smears as input may reduce the accuracy of the test. In conclusion, usage of cytological material as input to the Idylla EGFR test is possible. A workflow where common mutations are tested first and fast, leaving rarer mutations for subsequent comprehensive profiling, seems the most effective approach.

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Section: Discussionmentioning

confidence: 99%

Testing EGFR with Idylla on Cytological Specimens of Lung Cancer: A Review

Caputo

D'Ardia

Sabbatino

et al. 2021

IJMS

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“…Definitive diagnosis can be obtained by demonstrating the presence of Actinomyces in culture; however, bacterial growth is slow and the definitive evaluation of the presence of Actinomyces may require 2 to 3 weeks [1,2,5,13,14]. FNAC is a safe, rapid, and relatively inexpensive method: it allows obtaining an amount of material sufficient to make a diagnosis with lower costs and distress for the patients, and is routinely used to solve diagnostic conundrums in the head and neck district [6,7,[15][16][17][18]. FNAC can also be used to obtain material for bacterial cultures, histochemistry, immunohistochemistry, and molecular tests [12,[19][20][21][22][23][24][25].…”

Section: N Case Reportsmentioning

confidence: 99%

Actinomycosis mimicking malignancy: a report of three cases diagnosed with fine-needle aspiration cytology

et al. 2022

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We describe three cases of actinomycosis of the head and neck area, clinically suspected to be malignancies, diagnosed by fine-needle aspiration (FNAC). The patients presented with painless, slowly growing masses in the cervicofacial area. Ultrasonography identified the masses as enlarged lymph nodes which were subsequently biopsied by FNAC. Cytological features were similar in all cases, with a background of granulocytes and scattered lymphocytes and histiocytes. At high magnification colonies of branching, filamentous and beaded bacteria were detected. In the Diff-Quikstained smears, these filamentous colonies showed an evident yellowish color with the typical feature of the "sulfur granules" consistent with the Splendore-Hoep-SUMMARY pli phenomenon. A diagnosis of actinomycosis was made and confirmed in all cases by the subsequent microbiological tests. The patients were treated with high-dose penicillin, which caused the masses to progressively shrink. The lymph nodal localization of cervico-facial actinomycosis may be a diagnostic challenge, because in that area, lymphadenopathies may occur both in benign and malignant conditions. FNAC is a safe, fast, and reliable method to perform an accurate diagnosis of actinomycosis avoiding the surgical excision for histological evaluation.

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“…Fine‐needle aspiration cytology (FNAC) may be useful for the preoperative diagnosis of mesenchymal neoplasms, also thanks to the development of immunohistochemical and molecular markers with high specificity 4‐7 . Indeed, an accurate preoperative diagnosis is mandatory to avoid in some cases unnecessary demolitive surgery or not radical excision.…”

Section: Introductionmentioning

confidence: 99%

Giant cell‐rich extrapleural solitary fibrous tumor: Cytological findings and differential diagnosis of a rare neoplasm

Ronchi

Cozzolino

Montella

et al. 2020

Diagnostic Cytopathology

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Extrapleural solitary fibrous tumor (ESFT) is a rare neoplasm with a variable biological behavior that may occur almost everywhere in the body, as it has been reported in head and neck, back, retroperitoneum, inguinal region and more. The diagnosis of ESFT may be challenging, especially in case of its morphological rare variants such as giant cell‐rich ESFT. Fine‐needle aspiration cytology (FNAC) is a rapid, poorly invasive, safe diagnostic technique, which is recently proving useful for the preoperative diagnosis of mesenchymal neoplasms. Herein we report a case of a FNAC diagnosis of giant cell‐rich ESFT, focusing on its morphological and immunocytochemical characteristics, and showing how cytology may be an effective tool in the preoperative diagnosis of mesenchymal neoplasms, allowing the correct surgical management of the patient.

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Lipoma of the tongue diagnosed by fine‐needle aspiration cytology

Cited by 6 publications

References 12 publications

Testing EGFR with Idylla on Cytological Specimens of Lung Cancer: A Review

Testing EGFR with Idylla on Cytological Specimens of Lung Cancer: A Review

Actinomycosis mimicking malignancy: a report of three cases diagnosed with fine-needle aspiration cytology

Giant cell‐rich extrapleural solitary fibrous tumor: Cytological findings and differential diagnosis of a rare neoplasm

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